Sung, Ching-Hwa

Publications

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selected publications

Oxidative stress induces lysosomal membrane permeabilization and ceramide accumulation in retinal pigment epithelial cells. Disease models & mechanisms. 2023 Academic Article GET IT
Chondroitin sulfate enhances the barrier function of basement membrane assembled by heparan sulfate. Development (Cambridge, England). 2022 Academic Article GET IT
Times cited: 2
Visual pigment-deficient cones survive and mediate visual signaling despite the lack of outer segments. Proceedings of the National Academy of Sciences of the United States of America. 2022 Academic Article GET IT
Times cited: 4
Retinal pigment epithelium-specific CLIC4 mutant is a mouse model of dry age-related macular degeneration. Nature communications. 2022 Academic Article GET IT
Times cited: 6
CLIC4 regulates late endosomal trafficking and matrix degradation activity of MMP14 at focal adhesions in RPE cells. Scientific reports. 2019 Academic Article GET IT
Times cited: 12
The Late Endosomal Pathway Regulates the Ciliary Targeting of Tetraspanin Protein Peripherin 2. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2019 Academic Article GET IT
Times cited: 13
Ciliary Assembly/Disassembly Assay in Non-transformed Cell Lines. Bio-protocol. 2018 Academic Article GET IT
Tctex-1 controls ciliary resorption by regulating branched actin polymerization and endocytosis. EMBO reports. 2017 Academic Article GET IT
Times cited: 28
Nervous system development relies on endosomal trafficking. Neurogenesis (Austin, Tex.). 2017 Academic Article GET IT
Times cited: 101
The Biology of Ciliary Dynamics. Cold Spring Harbor perspectives in biology. 2017 Review GET IT
Times cited: 19
SARA regulates neuronal migration during neocortical development through L1 trafficking. Development (Cambridge, England). 2016 Academic Article GET IT
Times cited: 7
The Disease Protein Tulp1 Is Essential for Periactive Zone Endocytosis in Photoreceptor Ribbon Synapses. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2016 Academic Article GET IT
Times cited: 18
CLIC4 regulates apical exocytosis and renal tube luminogenesis through retromer- and actin-mediated endocytic trafficking. Nature communications. 2016 Academic Article GET IT
Times cited: 32
Light regulates the ciliary protein transport and outer segment disc renewal of mammalian photoreceptors. Developmental cell. 2015 Academic Article GET IT
Times cited: 14
Ultrastructural visualization of trans-ciliary rhodopsin cargoes in mammalian rods. Cilia. 2015 Academic Article GET IT
Times cited: 130
A dynein independent role of Tctex-1 at the kinetochore. Cell cycle (Georgetown, Tex.). 2015 Academic Article GET IT
Times cited: 10
Four-dimensional live imaging of apical biosynthetic trafficking reveals a post-Golgi sorting role of apical endosomal intermediates. Proceedings of the National Academy of Sciences of the United States of America. 2014 Academic Article GET IT
Times cited: 55
The roles of evolutionarily conserved functional modules in cilia-related trafficking. Nature cell biology. 2013 Review GET IT
Times cited: 150
IGF-1 activates a cilium-localized noncanonical Gβγ signaling pathway that regulates cell-cycle progression. Developmental cell. 2013 Academic Article GET IT
Times cited: 74
Restoration of vision after transplantation of photoreceptors. Nature. 2012 Academic Article GET IT
Times cited: 378
Ciliary resorption modulates G1 length and cell cycle progression. Cell cycle (Georgetown, Tex.). 2011 Editorial Article GET IT
Times cited: 13
Role of CLIC4 in the host innate responses to bacterial lipopolysaccharide. European journal of immunology. 2011 Academic Article GET IT
Times cited: 39
Ciliary transition zone activation of phosphorylated Tctex-1 controls ciliary resorption, S-phase entry and fate of neural progenitors. Nature cell biology. 2011 Academic Article GET IT
Times cited: 184
Tctex-1, a novel interaction partner of Rab3D, is required for osteoclastic bone resorption. Molecular and cellular biology. 2011 Academic Article GET IT
Times cited: 28
The cell biology of vision. The Journal of cell biology. 2010 Review GET IT
Times cited: 152
Identification of the Tctex-1 regulatory element that directs expression to neural stem/progenitor cells in developing and adult brain. The Journal of comparative neurology. 2010 Academic Article GET IT
Times cited: 12
Chloride intracellular channel 4 is critical for the epithelial morphogenesis of RPE cells and retinal attachment. Molecular biology of the cell. 2010 Academic Article GET IT
Times cited: 33
Evidence for the involvement of Lfc and Tctex-1 in axon formation. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2010 Academic Article GET IT
Times cited: 34
Nicotinamide adenine dinucleotide-dependent binding of the neuronal Ca2+ sensor protein GCAP2 to photoreceptor synaptic ribbons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2010 Academic Article GET IT
Times cited: 27
MTOC translocation modulates IS formation and controls sustained T cell signaling. The Journal of cell biology. 2008 Academic Article GET IT
Times cited: 136
RIBEYE recruits Munc119, a mammalian ortholog of the Caenorhabditis elegans protein unc119, to synaptic ribbons of photoreceptor synapses. The Journal of biological chemistry. 2008 Academic Article GET IT
Times cited: 50
SARA-regulated vesicular targeting underlies formation of the light-sensing organelle in mammalian rods. Cell. 2007 Academic Article GET IT
Times cited: 117
G protein beta gamma subunit interaction with the dynein light-chain component Tctex-1 regulates neurite outgrowth. The EMBO journal. 2007 Academic Article GET IT
Times cited: 61
Regulatory dissociation of Tctex-1 light chain from dynein complex is essential for the apical delivery of rhodopsin. Traffic (Copenhagen, Denmark). 2006 Academic Article GET IT
Times cited: 35
Dynein light chain Tctex-1 identifies neural progenitors in adult brain. The Journal of comparative neurology. 2006 Academic Article GET IT
Times cited: 16
Dynein light chain rp3 acts as a nuclear matrix-associated transcriptional modulator in a dynein-independent pathway. Journal of cell science. 2005 Academic Article GET IT
Times cited: 19
The dynein light chain Tctex-1 has a dynein-independent role in actin remodeling during neurite outgrowth. Developmental cell. 2005 Academic Article GET IT
Times cited: 101
Structural and functional impairment of endocytic pathways by retinitis pigmentosa mutant rhodopsin-arrestin complexes. The Journal of clinical investigation. 2004 Academic Article GET IT
Times cited: 64
SARA, a FYVE domain protein, affects Rab5-mediated endocytosis. Journal of cell science. 2002 Academic Article GET IT
Times cited: 53
Barrier to autointegration factor interacts with the cone-rod homeobox and represses its transactivation function. The Journal of biological chemistry. 2002 Academic Article GET IT
Times cited: 109
Protein Phosphatase 1 binds strongly to the retinoblastoma protein but not to p107 or p130 in vitro and in vivo. Current eye research. 2002 Academic Article GET IT
Times cited: 10
Characterization of a brain-enriched chaperone, MRJ, that inhibits Huntingtin aggregation and toxicity independently. The Journal of biological chemistry. 2002 Academic Article GET IT
Times cited: 91
Fibroblast growth factor-2 decreases hyperoxia-induced photoreceptor cell death in mice. The American journal of pathology. 2001 Academic Article GET IT
Times cited: 78
Subunit heterogeneity of cytoplasmic dynein: Differential expression of 14 kDa dynein light chains in rat hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2001 Academic Article GET IT
Times cited: 34
Cytoplasmic dynein regulation by subunit heterogeneity and its role in apical transport. The Journal of cell biology. 2001 Academic Article GET IT
Times cited: 106
Association of Trk neurotrophin receptors with components of the cytoplasmic dynein motor. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2001 Academic Article GET IT
Times cited: 160
Rhodopsin trafficking and its role in retinal dystrophies. International review of cytology. 2000 Review GET IT
Times cited: 84
Rhodopsin's carboxy-terminal cytoplasmic tail acts as a membrane receptor for cytoplasmic dynein by binding to the dynein light chain Tctex-1. Cell. 1999 Academic Article GET IT
Times cited: 402
A 29 kDa intracellular chloride channel p64H1 is associated with large dense-core vesicles in rat hippocampal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 1999 Academic Article GET IT
Times cited: 75
The cytoplasmic tail of rhodopsin acts as a novel apical sorting signal in polarized MDCK cells. The Journal of cell biology. 1998 Academic Article GET IT
Times cited: 135
Localization of Tctex-1, a cytoplasmic dynein light chain, to the Golgi apparatus and evidence for dynein complex heterogeneity. The Journal of biological chemistry. 1998 Academic Article GET IT
Times cited: 70
Protection of mouse photoreceptors by survival factors in retinal degenerations. Investigative ophthalmology & visual science. 1998 Academic Article GET IT
Times cited: 476
The bZIP transcription factor Nrl stimulates rhodopsin promoter activity in primary retinal cell cultures. The Journal of biological chemistry. 1996 Academic Article GET IT
Times cited: 128
A rhodopsin gene mutation responsible for autosomal dominant retinitis pigmentosa results in a protein that is defective in localization to the photoreceptor outer segment. The Journal of neuroscience : the official journal of the Society for Neuroscience. 1994 Academic Article GET IT
Times cited: 300
Phenotypes of stop codon and splice site rhodopsin mutations causing retinitis pigmentosa. Investigative ophthalmology & visual science. 1994 Academic Article GET IT
Times cited: 62
Apoptotic photoreceptor cell death in mouse models of retinitis pigmentosa. Proceedings of the National Academy of Sciences of the United States of America. 1994 Academic Article GET IT
Times cited: 582
Rhodopsin mutations responsible for autosomal dominant retinitis pigmentosa. Clustering of functional classes along the polypeptide chain. The Journal of biological chemistry. 1993 Academic Article GET IT
Times cited: 273
Abnormal rod dark adaptation in autosomal dominant retinitis pigmentosa with proline-23-histidine rhodopsin mutation. American journal of ophthalmology. 1992 Academic Article GET IT
Times cited: 64
Molecular genetics of human visual pigments. Annual review of genetics. 1992 Review GET IT
Times cited: 86
Visual pigments and inherited variation in human vision. Society of General Physiologists series. 1992 Review GET IT
Times cited: 4
Functional heterogeneity of mutant rhodopsins responsible for autosomal dominant retinitis pigmentosa. Proceedings of the National Academy of Sciences of the United States of America. 1991 Academic Article GET IT
Times cited: 406
Retinal function and rhodopsin levels in autosomal dominant retinitis pigmentosa with rhodopsin mutations. American journal of ophthalmology. 1991 Academic Article GET IT
Times cited: 105
Rhodopsin mutations in autosomal dominant retinitis pigmentosa. Proceedings of the National Academy of Sciences of the United States of America. 1991 Academic Article GET IT
Times cited: 346
Expression of class I and class II major histocompatibility antigens on human hepatocellular carcinoma. The Journal of clinical investigation. 1989 Academic Article GET IT
Times cited: 28

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Research

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Funding awarded

Modeling and mechanistic investigation of a novel dry AMD mouse model with CLIC4 deleted in RPE awarded by National Eye Institute/NIH/DHHS Principal Investigator 2021 - 2025

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Background

education and training

Ph.D., National Yang-Ming Medical College (Taiwan) 1989
B.S., National Taiwan University (Taiwan) 1984

Contact

full name

Ching-Hwa Sung

primary email

chsung@med.cornell.edu

VIVO Weill Cornell Medical College

Ching-Hwa Sung Professor of Cell Biology in Ophthalmology

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email