Diversity-oriented synthesis: exploring the intersections between chemistry and biology. Review uri icon

Overview

abstract

  • Diversity-oriented synthesis (DOS) is an emerging field involving the synthesis of combinatorial libraries of diverse small molecules for biological screening. Rather than being directed toward a single biological target, DOS libraries can be used to identify new ligands for a variety of targets. Several different strategies for library design have been developed to target the biologically relevant regions of chemical structure space. DOS has provided powerful probes to investigate biological mechanisms and also served as a new driving force for advancing synthetic organic chemistry.

publication date

  • July 1, 2005

Research

keywords

  • Biology
  • Chemistry, Organic
  • Combinatorial Chemistry Techniques
  • Drug Design

Identity

Scopus Document Identifier

  • 33644839988

Digital Object Identifier (DOI)

  • 10.1038/nchembio0705-74

PubMed ID

  • 16408003

Additional Document Info

volume

  • 1

issue

  • 2