Levitz, Joshua

Publications

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Co-Author Network

selected publications

Control of Gα_q signaling dynamics and GPCR cross-talk by GRKs. Science advances. 2022 Academic Article GET IT
A ciliary synapse for "short-circuit" neuromodulation. Cell. 2022 Comment GET IT
Editorial overview: Special Issue on 'Chemogenetics and photopharmacology'. Current opinion in pharmacology. 2022 Editorial Article GET IT
Sulfonated red and far-red rhodamines to visualize SNAP- and Halo-tagged cell surface proteins. Organic & biomolecular chemistry. 2022 Academic Article GET IT
Times cited: 7
Photoswitchable Serotonins for Optical Control of the 5-HT_2A Receptor. Angewandte Chemie (International ed. in English). 2022 Academic Article GET IT
Times cited: 13
Advances in tethered photopharmacology for precise optical control of signaling proteins. Current opinion in pharmacology. 2022 Review GET IT
Times cited: 1
Structural and compositional diversity in the kainate receptor family. Cell reports. 2021 Academic Article GET IT
Times cited: 9
Unusual mode of dimerization of retinitis pigmentosa-associated F220C rhodopsin. Scientific reports. 2021 Academic Article GET IT
Times cited: 4
Mechanisms of differential desensitization of metabotropic glutamate receptors. Cell reports. 2021 Academic Article GET IT
Times cited: 9
Differences in interactions between transmembrane domains tune the activation of metabotropic glutamate receptors. eLife. 2021 Academic Article GET IT
Times cited: 11
A fine-tuned azobenzene for enhanced photopharmacology in vivo. Cell chemical biology. 2021 Academic Article GET IT
Times cited: 20
Structural and Biophysical Mechanisms of Class C G Protein-Coupled Receptor Function. Trends in biochemical sciences. 2020 Review GET IT
Times cited: 33
Interrogating surface versus intracellular transmembrane receptor populations using cell-impermeable SNAP-tag substrates. Chemical science. 2020 Academic Article GET IT
Times cited: 530
Defining the Homo- and Heterodimerization Propensities of Metabotropic Glutamate Receptors. Cell reports. 2020 Article GET IT
Times cited: 5
Defining the Homo- and Heterodimerization Propensities of Metabotropic Glutamate Receptors. Cell reports. 2020 Academic Article GET IT
Times cited: 29
Optogenetic Techniques for Manipulating and Sensing G Protein-Coupled Receptor Signaling. Methods in molecular biology (Clifton, N.J.). 2020 Review GET IT
Times cited: 4
Conformational pathway provides unique sensitivity to a synaptic mGluR. Nature communications. 2019 Academic Article GET IT
Times cited: 33
Branched Photoswitchable Tethered Ligands Enable Ultra-efficient Optical Control and Detection of G Protein-Coupled Receptors In Vivo. Neuron. 2019 Academic Article GET IT
Times cited: 39
Genetically Targeted Optical Control of an Endogenous G Protein-Coupled Receptor. Journal of the American Chemical Society. 2019 Academic Article GET IT
Times cited: 39
Conformational dynamics between transmembrane domains and allosteric modulation of a metabotropic glutamate receptor. eLife. 2019 Academic Article GET IT
Times cited: 31
Restoration of high-sensitivity and adapting vision with a cone opsin. Nature communications. 2019 Academic Article GET IT
Times cited: 80
Structural basis for KCTD-mediated rapid desensitization of GABA_B signalling. Nature. 2019 Academic Article GET IT
Times cited: 44
Optical Regulation of Class C GPCRs by Photoswitchable Orthogonal Remotely Tethered Ligands. Methods in molecular biology (Clifton, N.J.). 2019 Academic Article GET IT
Times cited: 4
Migraine-Associated TRESK Mutations Increase Neuronal Excitability through Alternative Translation Initiation and Inhibition of TREK. Neuron. 2018 Academic Article GET IT
Times cited: 72
SNAP-Tagged Nanobodies Enable Reversible Optical Control of a G Protein-Coupled Receptor via a Remotely Tethered Photoswitchable Ligand. ACS chemical biology. 2018 Academic Article GET IT
Times cited: 32
Glutamatergic Signaling in the Central Nervous System: Ionotropic and Metabotropic Receptors in Concert. Neuron. 2018 Review GET IT
Times cited: 281
Author Correction: Restoration of patterned vision with an engineered photoactivatable G protein-coupled receptor. Nature communications. 2018 Academic Article GET IT
Optical Control of Dopamine Receptors Using a Photoswitchable Tethered Inverse Agonist. Journal of the American Chemical Society. 2017 Academic Article GET IT
Times cited: 51
An engineered opsin monomer scrambles phospholipids. Scientific reports. 2017 Academic Article GET IT
Times cited: 10
Restoration of patterned vision with an engineered photoactivatable G protein-coupled receptor. Nature communications. 2017 Academic Article GET IT
Times cited: 61
Dual optical control and mechanistic insights into photoswitchable group II and III metabotropic glutamate receptors. Proceedings of the National Academy of Sciences of the United States of America. 2017 Academic Article GET IT
Times cited: 55
Mechanism of Assembly and Cooperativity of Homomeric and Heteromeric Metabotropic Glutamate Receptors. Neuron. 2016 Academic Article GET IT
Times cited: 108
Heterodimerization within the TREK channel subfamily produces a diverse family of highly regulated potassium channels. Proceedings of the National Academy of Sciences of the United States of America. 2016 Academic Article GET IT
Times cited: 51
A Toolkit for Orthogonal and in vivo Optical Manipulation of Ionotropic Glutamate Receptors. Frontiers in molecular neuroscience. 2016 Academic Article GET IT
Times cited: 322
Optical control of neuronal activity using a light-operated GIRK channel opener (LOGO). Chemical science. 2015 Academic Article GET IT
Times cited: 40
Orthogonal Optical Control of a G Protein-Coupled Receptor with a SNAP-Tethered Photochromic Ligand. ACS central science. 2015 Academic Article GET IT
Times cited: 135
Conformational dynamics of a class C G-protein-coupled receptor. Nature. 2015 Academic Article GET IT
Times cited: 118
Two-photon brightness of azobenzene photoswitches designed for glutamate receptor optogenetics. Proceedings of the National Academy of Sciences of the United States of America. 2015 Academic Article GET IT
Times cited: 80
Controlling ionotropic and metabotropic glutamate receptors with light: principles and potential. Current opinion in pharmacology. 2015 Review GET IT
Times cited: 45
Phospholipase D2 specifically regulates TREK potassium channels via direct interaction and local production of phosphatidic acid. Proceedings of the National Academy of Sciences of the United States of America. 2014 Academic Article GET IT
Times cited: 37
Bringing optogenetics to the synapse. Neuron. 2013 Comment GET IT
Times cited: 2
Optogenetic techniques for the study of native potassium channels. Frontiers in molecular neuroscience. 2013 Academic Article GET IT
Times cited: 137
Optical control of metabotropic glutamate receptors. Nature neuroscience. 2013 Academic Article GET IT
Times cited: 167
Optical control of endogenous proteins with a photoswitchable conditional subunit reveals a role for TREK1 in GABA(B) signaling. Neuron. 2012 Academic Article GET IT
Times cited: 84
A mechanism for tunable autoinhibition in the structure of a human Ca2+/calmodulin- dependent kinase II holoenzyme. Cell. 2011 Academic Article GET IT
Times cited: 176

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Research

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Co-investigator Network

Funding awarded

Mechanisms of Regulation of Metabotropic Glutamate Receptors awarded by National Institute of Neurological Disorders & Stroke Principal Investigator 2023 - 2028
Molecular and synaptic mechanisms of neurotrophin-glutamate crosstalk awarded by National Institute of Neurological Disorders & Stroke Principal Investigator 2022 - 2027
Photopharmacological interrogation of presynaptic neuromodulation of cortico-amygdalar circuits awarded by National Institute of Mental Health Principal Investigator 2022 - 2027
Genetically-Targeted Photo-Pharmacology for Native Opioid Receptors awarded by National Institute on Drug Abuse Principal Investigator 2020 - 2024
Molecular Mechanisms of Synaptic G Protein-Coupled Receptors awarded by National Institute of General Medical Sciences Principal Investigator 2017 - 2023

Circuit and Synaptic Mechanisms of Endocannabinoid-Opioid Crosstalk awarded by National Institute on Drug Abuse Co-Investigator 2022 - 2027
A Molecular Framework to Define Slitrk5 Function Related to OCD awarded by Foundation for OCD Research Co-Investigator 2023 - 2026

Structure and function of mGluR3 interactions with beta-arrestins and the membrane. awarded by National Institute of General Medical Sciences Key Personnel 2022 - 2024

Structure and function of GPCR heteromeric complexes in brain awarded by National Institute of Mental Health Principal Investigator Subaward 2019 - 2024

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Background

education and training

Ph.D., University of California, Berkeley 2014
B.S., American University 2009

Contact

full name

Joshua Levitz

primary email

jtl2003@med.cornell.edu

VIVO Weill Cornell Medical College

Joshua Levitz Associate Professor of Biochemistry

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

Phone

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email