Kaplitt, Michael G

Publications

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selected publications

Cranial MRgFUS intraprocedural diffusion and T2 imaging and comparison with postablation lesion size and location. Journal of neurosurgery. 2023 Academic Article GET IT
Trial of Globus Pallidus Focused Ultrasound Ablation in Parkinson's Disease. The New England journal of medicine. 2023 Academic Article GET IT
Times cited: 6
Focused ultrasound-mediated blood-brain barrier opening in Alzheimer's disease: long-term safety, imaging, and cognitive outcomes. Journal of neurosurgery. 2022 Academic Article GET IT
Mapping and targeted viral activation of pancreatic nerves in mice reveal their roles in the regulation of glucose metabolism. Nature biomedical engineering. 2022 Academic Article GET IT
Times cited: 1
Monocyte-derived SDF1 supports optic nerve regeneration and alters retinal ganglion cells' response to Pten deletion. Proceedings of the National Academy of Sciences of the United States of America. 2022 Academic Article GET IT
Times cited: 10
Author Correction: Disruption of mitochondrial complex I induces progressive parkinsonism. Nature. 2022 Article GET IT
Times cited: 1
Characterization of a Low-Profile, Flexible, and Acoustically Transparent Receive-Only MRI Coil Array for High Sensitivity MR-Guided Focused Ultrasound. IEEE access : practical innovations, open solutions. 2022 Academic Article GET IT
Times cited: 223
The Brain-Nose Interface: A Potential Cerebrospinal Fluid Clearance Site in Humans. Frontiers in physiology. 2022 Review GET IT
Times cited: 87
Disruption of mitochondrial complex I induces progressive parkinsonism. Nature. 2021 Academic Article GET IT
Times cited: 125
Neuromodulatory effect of interleukin 1β in the dorsal raphe nucleus on individual differences in aggression. Molecular psychiatry. 2021 Academic Article GET IT
Times cited: 5
Cranial MR-Guided Focused Ultrasound: Clinical Challenges and Future Directions. World neurosurgery. 2021 Review GET IT
Times cited: 1
Foundations of Magnetic Resonance-Guided Focused Ultrasonography. World neurosurgery. 2021 Review GET IT
Times cited: 2
Innovative Applications of MR-Guided Focused Ultrasound for Neurological Disorders. World neurosurgery. 2021 Review GET IT
Times cited: 6
Slowing late infantile Batten disease by direct brain parenchymal administration of a rh.10 adeno-associated virus expressing CLN2. Science translational medicine. 2020 Academic Article GET IT
Times cited: 27
β-Amyloid Plaque Reduction in the Hippocampus After Focused Ultrasound-Induced Blood-Brain Barrier Opening in Alzheimer's Disease. Frontiers in human neuroscience. 2020 Academic Article GET IT
Times cited: 600
Predictors of Outcomes After Focused Ultrasound Thalamotomy. Neurosurgery. 2020 Academic Article GET IT
Times cited: 31
Improved targeting of the globus pallidus interna using quantitative susceptibility mapping prior to MR-guided focused ultrasound ablation in Parkinson's disease. Clinical imaging. 2020 Academic Article GET IT
Times cited: 5
Personalized iPSC-Derived Dopamine Progenitor Cells for Parkinson's Disease. 2020 GET IT
Times cited: 213
Editorial. COVID-19 and neurosurgical practice: an interim report. Journal of neurosurgery. 2020 Editorial Article GET IT
Times cited: 23
Noninvasive hippocampal blood-brain barrier opening in Alzheimer's disease with focused ultrasound. Proceedings of the National Academy of Sciences of the United States of America. 2020 Academic Article GET IT
Times cited: 136
Framework for advancing rigorous research. eLife. 2020 Academic Article GET IT
Times cited: 10
Gene-targeting approaches for movement disorders: recent advances. Current opinion in neurology. 2019 Review GET IT
Times cited: 3
Magnetic resonance-guided focused ultrasound for ablation of mesial temporal epilepsy circuits: modeling and theoretical feasibility of a novel noninvasive approach. Journal of neurosurgery. 2019 Academic Article GET IT
Times cited: 12
Correction to: Cranial MR-guided Focused Ultrasound for Essential Tremor : Technical Considerations and Image Guidance. Clinical neuroradiology. 2019 Academic Article GET IT
Times cited: 1
Impact of skull density ratio on efficacy and safety of magnetic resonance-guided focused ultrasound treatment of essential tremor. Journal of neurosurgery. 2019 Academic Article GET IT
Times cited: 37
Mutant huntingtin enhances activation of dendritic Kv4 K⁺ channels in striatal spiny projection neurons. eLife. 2019 Academic Article GET IT
Times cited: 18
Repeat magnetic resonance imaging-guided focused ultrasound thalamotomy for recurrent essential tremor: case report and review of MRI findings. 2019 GET IT
Times cited: 15
Gene therapy reduces Parkinson's disease symptoms by reorganizing functional brain connectivity. Science translational medicine. 2018 Academic Article GET IT
Times cited: 47
Cranial MR-guided Focused Ultrasound for Essential Tremor : Technical Considerations and Image Guidance. Clinical neuroradiology. 2018 Academic Article GET IT
Times cited: 5
Neurological adverse event profile of magnetic resonance imaging-guided focused ultrasound thalamotomy for essential tremor. Movement disorders : official journal of the Movement Disorder Society. 2018 Academic Article GET IT
Times cited: 67
Safe and stable noninvasive focal gene delivery to the mammalian brain following focused ultrasound. Journal of neurosurgery. 2018 Academic Article GET IT
Times cited: 51
AAVrh.10-Mediated APOE2 Central Nervous System Gene Therapy for APOE4-Associated Alzheimer's Disease. Human gene therapy. Clinical development. 2018 Academic Article GET IT
Times cited: 70
Characterization of early-onset motor deficits in the Pink1-/- mouse model of Parkinson disease. Brain research. 2017 Academic Article GET IT
Times cited: 26
Clinical improvement associated with targeted interruption of the cerebellothalamic tract following MR-guided focused ultrasound for essential tremor. Journal of neurosurgery. 2017 Academic Article GET IT
Times cited: 76
Long-term follow-up of a randomized AAV2-GAD gene therapy trial for Parkinson's disease. JCI insight. 2017 Academic Article GET IT
Times cited: 72
Clinical quantitative susceptibility mapping (QSM): Biometal imaging and its emerging roles in patient care. Journal of magnetic resonance imaging : JMRI. 2017 Review GET IT
Times cited: 160
Gene therapy blockade of dorsal striatal p11 improves motor function and dyskinesia in parkinsonian mice. Proceedings of the National Academy of Sciences of the United States of America. 2016 Academic Article GET IT
Times cited: 19
p11 modulates L-DOPA therapeutic effects and dyskinesia via distinct cell types in experimental Parkinsonism. Proceedings of the National Academy of Sciences of the United States of America. 2016 Academic Article GET IT
Times cited: 11
Opposing roles for serotonin in cholinergic neurons of the ventral and dorsal striatum. Proceedings of the National Academy of Sciences of the United States of America. 2016 Academic Article GET IT
Times cited: 33
The tumor suppressor PTEN regulates motor responses to striatal dopamine in normal and Parkinsonian animals. Neurobiology of disease. 2015 Academic Article GET IT
Times cited: 12
[Depression and addiction comorbidity: towards a common molecular target?]. Medecine sciences : M/S. 2015 Review GET IT
Times cited: 8
Correction. Proceedings of the National Academy of Sciences of the United States of America. 2015 Article GET IT
The Nucleus Accumbens: A Comprehensive Review. Stereotactic and functional neurosurgery. 2015 Academic Article GET IT
Times cited: 237
Nitric oxide regulates synaptic transmission between spiny projection neurons. Proceedings of the National Academy of Sciences of the United States of America. 2014 Academic Article GET IT
Times cited: 23
Treatment of chronic pain: diffusion tensor imaging identification of the ventroposterolateral nucleus confirmed with successful deep brain stimulation. Stereotactic and functional neurosurgery. 2014 Academic Article GET IT
Times cited: 14
Tight regulation between cell survival and programmed cell death in GBM stem-like cells by EGFR/GSK3b/PP2A signaling. Journal of neuro-oncology. 2014 Academic Article GET IT
Times cited: 24
Network modulation following sham surgery in Parkinson's disease. The Journal of clinical investigation. 2014 Academic Article GET IT
Times cited: 59
Impaired TrkB receptor signaling underlies corticostriatal dysfunction in Huntington's disease. Neuron. 2014 Academic Article GET IT
Times cited: 142
PTEN knockdown alters dendritic spine/protrusion morphology, not density. The Journal of comparative neurology. 2014 Academic Article GET IT
Times cited: 42
Cell-type specific expression of p11 controls cocaine reward. Biological psychiatry. 2014 Academic Article GET IT
Times cited: 27
Consensus on guidelines for stereotactic neurosurgery for psychiatric disorders. 2014 GET IT
Times cited: 137
Spectrum of ocular manifestations in CLN2-associated batten (Jansky-Bielschowsky) disease correlate with advancing age and deteriorating neurological function. PloS one. 2013 Academic Article GET IT
Times cited: 32
Spinal cord stimulation for vegetative state: is this ready for prime time?. Stereotactic and functional neurosurgery. 2013 Comment GET IT
Times cited: 2
Improved subthalamic nucleus depiction with quantitative susceptibility mapping. Radiology. 2013 Academic Article GET IT
Times cited: 110
Intrathecal pain pump infusions for intractable cancer pain: an algorithm for dosing without a neuraxial trial. Anesthesia and analgesia. 2013 Academic Article GET IT
Times cited: 24
Gene therapy for psychiatric disorders. World neurosurgery. 2012 Review GET IT
Times cited: 19
Long-term expression and safety of administration of AAVrh.10hCLN2 to the brain of rats and nonhuman primates for the treatment of late infantile neuronal ceroid lipofuscinosis. Human gene therapy methods. 2012 Academic Article GET IT
Times cited: 75
Assessment of disease severity in late infantile neuronal ceroid lipofuscinosis using multiparametric MR imaging. AJNR. American journal of neuroradiology. 2012 Academic Article GET IT
Times cited: 16
Bidirectional regulation of emotional memory by 5-HT1B receptors involves hippocampal p11. Molecular psychiatry. 2012 Academic Article GET IT
Times cited: 36
Cholinergic interneurons in the nucleus accumbens regulate depression-like behavior. Proceedings of the National Academy of Sciences of the United States of America. 2012 Academic Article GET IT
Times cited: 122
Improved sequence learning with subthalamic nucleus deep brain stimulation: evidence for treatment-specific network modulation. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2012 Academic Article GET IT
Times cited: 46
AAV2-GAD gene therapy for advanced Parkinson's disease: a double-blind, sham-surgery controlled, randomised trial. The Lancet. Neurology. 2011 Academic Article GET IT
Times cited: 481
Optimization of glioblastoma multiforme stem cell isolation, transfection, and transduction. Journal of neuro-oncology. 2011 Academic Article GET IT
Times cited: 15
Postshunt cognitive and functional improvement in idiopathic normal pressure hydrocephalus. Neurosurgery. 2011 Academic Article GET IT
Times cited: 44
Adeno-associated viral gene delivery in neurodegenerative disease. Methods in molecular biology (Clifton, N.J.). 2011 Academic Article GET IT
Times cited: 10
Reversal of depressed behaviors in mice by p11 gene therapy in the nucleus accumbens. Science translational medicine. 2010 Academic Article GET IT
Times cited: 78
Gene therapy for late infantile neuronal ceroid lipofuscinosis: neurosurgical considerations. Journal of neurosurgery. Pediatrics. 2010 Academic Article GET IT
Times cited: 56
Electrical stimulation of the anterior nucleus of thalamus for treatment of refractory epilepsy. Epilepsia. 2010 Academic Article GET IT
Times cited: 1252
Parkinson disease: Another player in gene therapy for Parkinson disease. Nature reviews. Neurology. 2010 Article GET IT
Times cited: 11
Novel mitochondrial substrates of omi indicate a new regulatory role in neurodegenerative disorders. PloS one. 2009 Academic Article GET IT
Times cited: 19
Assessing the microlesion effect of subthalamic deep brain stimulation surgery with FDG PET. Journal of neurosurgery. 2009 Academic Article GET IT
Times cited: 49
Clinical trials of surgical devices for neurological disorders. Frontiers of neurology and neuroscience. 2009 Academic Article GET IT
Gene therapy clinical trials in the human brain. Protocol development and review of current applications. Frontiers of neurology and neuroscience. 2009 Review GET IT
Times cited: 7
PINK1 defect causes mitochondrial dysfunction, proteasomal deficit and alpha-synuclein aggregation in cell culture models of Parkinson's disease. PloS one. 2009 Academic Article GET IT
Times cited: 117
Viral vector-mediated overexpression of estrogen receptor-alpha in striatum enhances the estradiol-induced motor activity in female rats and estradiol-modulated GABA release. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2009 Academic Article GET IT
Times cited: 85
Treatment of late infantile neuronal ceroid lipofuscinosis by CNS administration of a serotype 2 adeno-associated virus expressing CLN2 cDNA. Human gene therapy. 2008 Academic Article GET IT
Times cited: 300
Modulation of metabolic brain networks after subthalamic gene therapy for Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America. 2007 Academic Article GET IT
Times cited: 158
Progress and prospects: gene therapy clinical trials (part 1). Gene therapy. 2007 Review GET IT
Times cited: 87
Neurological deterioration in late infantile neuronal ceroid lipofuscinosis. Neurology. 2007 Academic Article GET IT
Times cited: 71
Safety and tolerability of gene therapy with an adeno-associated virus (AAV) borne GAD gene for Parkinson's disease: an open label, phase I trial. Lancet (London, England). 2007 Academic Article GET IT
Times cited: 850
Protection against cisplatin-induced ototoxicity by adeno-associated virus-mediated delivery of the X-linked inhibitor of apoptosis protein is not dependent on caspase inhibition. Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology. 2007 Academic Article GET IT
Times cited: 29
Silencing of estrogen receptor alpha in the ventromedial nucleus of hypothalamus leads to metabolic syndrome. Proceedings of the National Academy of Sciences of the United States of America. 2007 Academic Article GET IT
Times cited: 403
Network modulation in the treatment of Parkinson's disease. Brain : a journal of neurology. 2006 Academic Article GET IT
Times cited: 293
Subthalamic glutamic acid decarboxylase gene therapy: changes in motor function and cortical metabolism. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2006 Academic Article GET IT
Times cited: 110
PTEN inhibits adrenomedullin expression and function in brain tumor cells. Journal of neuro-oncology. 2006 Academic Article GET IT
Times cited: 3
RNAi-mediated silencing of estrogen receptor {alpha} in the ventromedial nucleus of hypothalamus abolishes female sexual behaviors. Proceedings of the National Academy of Sciences of the United States of America. 2006 Academic Article GET IT
Times cited: 185
AAV-mediated delivery of the caspase inhibitor XIAP protects against cisplatin ototoxicity. Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology. 2006 Academic Article GET IT
Times cited: 58
Confronting the issues of therapeutic misconception, enrollment decisions, and personal motives in genetic medicine-based clinical research studies for fatal disorders. Human gene therapy. 2005 Review GET IT
Times cited: 29
Inhibition of neuronal phenotype by PTEN in PC12 cells. Proceedings of the National Academy of Sciences of the United States of America. 2004 Academic Article GET IT
Times cited: 64
The subthalamic nucleus in the context of movement disorders. Brain : a journal of neurology. 2003 Review GET IT
Times cited: 461
Future and current surgical therapies in Parkinson's disease. Current opinion in neurology. 2003 Review GET IT
Times cited: 51
Gene transfer and in vivo promoter analysis of the rat progesterone receptor using a herpes simplex virus viral vector. Brain research. Molecular brain research. 2003 Academic Article GET IT
Times cited: 4
A cis-acting element that directs circular adeno-associated virus replication and packaging. Journal of virology. 2002 Academic Article GET IT
Times cited: 30
Subthalamic GAD gene therapy in a Parkinson's disease rat model. Science (New York, N.Y.). 2002 Academic Article GET IT
Times cited: 291
Subthalamic GAD gene transfer in Parkinson disease patients who are candidates for deep brain stimulation. Human gene therapy. 2001 Academic Article GET IT
Times cited: 180
Tension pneumocephalus resulting from iatrogenic subarachnoid-pleural fistulae: report of three cases. 2001 GET IT
Times cited: 39
Surgical drug delivery for neurodegenerative diseases. Clinical neurosurgery. 2001 Review GET IT
Times cited: 2
Early region 1 transforming functions are dispensable for mammary tumorigenesis by human adenovirus type 9. Journal of virology. 1999 Academic Article GET IT
Times cited: 22
Experimental gene therapy against subcutaneously implanted glioma with a herpes simplex virus-defective vector expressing interferon-gamma. Cancer gene therapy. 1999 Academic Article GET IT
Times cited: 23
Peroral gene therapy of lactose intolerance using an adeno-associated virus vector. Nature medicine. 1998 Academic Article GET IT
Times cited: 129
In vivo expression of therapeutic human genes for dopamine production in the caudates of MPTP-treated monkeys using an AAV vector. Gene therapy. 1998 Academic Article GET IT
Times cited: 155
In situ PCR for in vivo detection of foreign genes transferred into rat brain. Brain research. 1998 Academic Article GET IT
Times cited: 3
Prospects for gene therapy in pediatric neurosurgery. Pediatric neurosurgery. 1998 Review GET IT
Times cited: 8
Defective adenoassociated viral-mediated transfection of insulin gene by direct injection into liver parenchyma decreases blood glucose of diabetic mice. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. 1997 Academic Article GET IT
Times cited: 32
Adenovirus vector-mediated gene transfer into human epileptogenic brain slices: prospects for gene therapy in epilepsy. Experimental neurology. 1997 Academic Article GET IT
Times cited: 21
Efficient gene transfer into primary and immortalized human fetal glial cells using adeno-associated virus vectors: establishment of a glial cell line with a functional CD4 receptor. Journal of neurovirology. 1997 Academic Article GET IT
Times cited: 21
Adeno-associated viral vector gene transfer into leptomeningeal xenografts. Journal of neuro-oncology. 1997 Academic Article GET IT
Times cited: 26
Adenoviral vector-mediated expression of B-50/GAP-43 induces alterations in the membrane organization of olfactory axon terminals in vivo. The Journal of neuroscience : the official journal of the Society for Neuroscience. 1997 Academic Article GET IT
Times cited: 40
Direct gene transfer into human epileptogenic hippocampal tissue with an adeno-associated virus vector: implications for a gene therapy approach to epilepsy. Epilepsia. 1997 Academic Article GET IT
Times cited: 28
Defective viral vectors as agents for gene transfer in the nervous system. Journal of neuroscience methods. 1997 Review GET IT
Times cited: 36
Apolipoprotein E, A beta-amyloid, and the molecular pathology of Alzheimer's disease. Therapeutic implications. Annals of the New York Academy of Sciences. 1996 Academic Article GET IT
Times cited: 10
Long-term gene transfer in porcine myocardium after coronary infusion of an adeno-associated virus vector. The Annals of thoracic surgery. 1996 Academic Article GET IT
Times cited: 109
Viral Vectors for Gene Delivery and Expression in the CNS. Methods (San Diego, Calif.). 1996 Academic Article GET IT
Efficient adenoviral vector-directed expression of a foreign gene to neurons and sustentacular cells in the mouse olfactory neuroepithelium. Brain research. Molecular brain research. 1996 Academic Article GET IT
Times cited: 26
Continuous renewal of the axonal pathway sensor apparatus by insertion of new sensor molecules into the growth cone membrane. Current biology : CB. 1996 Academic Article GET IT
Times cited: 56
Prospects for gene therapy in Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society. 1996 Review GET IT
Times cited: 30
Transfection of human lactotroph adenoma cells with an adenovirus vector expressing tyrosine hydroxylase decreases prolactin release. The Journal of clinical endocrinology and metabolism. 1996 Academic Article GET IT
Times cited: 23
Gene transfer of wild-type p53 results in restoration of tumor-suppressor function in a medulloblastoma cell line. Neurology. 1995 Academic Article GET IT
Times cited: 41
RG-2 glioma growth attenuation and severe brain edema caused by local production of interleukin-2 and interferon-gamma. Cancer research. 1995 Academic Article GET IT
Specific patterns of defective HSV-1 gene transfer in the adult central nervous system: implications for gene targeting. Experimental neurology. 1994 Academic Article GET IT
Expression of the growth-associated protein B-50/GAP43 via a defective herpes-simplex virus vector results in profound morphological changes in non-neuronal cells. Brain research. Molecular brain research. 1994 Academic Article GET IT
Times cited: 37
Linear dimeric interleukin-2 obtained by the use of a defective herpes simplex viral vector: conformation-activity relationship. Brain research. Molecular brain research. 1994 Academic Article GET IT
Times cited: 4
Long-term gene expression and phenotypic correction using adeno-associated virus vectors in the mammalian brain. Nature genetics. 1994 Academic Article GET IT
Times cited: 920
Preproenkephalin promoter yields region-specific and long-term expression in adult brain after direct in vivo gene transfer via a defective herpes simplex viral vector. Proceedings of the National Academy of Sciences of the United States of America. 1994 Academic Article GET IT
Times cited: 146
Prolactin, central nervous system and behavior: a critical review. Neuroendocrinology. 1994 Review GET IT
Times cited: 67
B-50/GAP-43 expression via a defective herpes simplex virus vector results in persistent morphological changes in non-neuronal cells. Gene therapy. 1994 Academic Article GET IT
Times cited: 1
Mutant herpes simplex virus induced regression of tumors growing in immunocompetent rats. Journal of neuro-oncology. 1994 Academic Article GET IT
Times cited: 54
Detection of messenger RNA and low-abundance heteronuclear RNA with single-stranded DNA probes produced by amplified primer extension labeling. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. 1993 Academic Article GET IT
Times cited: 26
Estrogen increases HIP-70/PLC-alpha messenger ribonucleic acid in the rat uterus and hypothalamus. Endocrinology. 1993 Academic Article GET IT
Times cited: 15
PLC-alpha: a common mediator of the action of estrogen and other hormones?. Molecular and cellular endocrinology. 1991 Review GET IT
Times cited: 43
Expression of a functional foreign gene in adult mammalian brain following in Vivo transfer via a herpes simplex virus type 1 defective viral vector. Molecular and cellular neurosciences. 1991 Academic Article GET IT

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Research

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Funding awarded

MeiraGTx Biopharma Alliance Agreement awarded by MeiraGTx, LLC Principal Investigator 2021 - 2025
Gene therapy to address unmet needs in Parkinson''s Disease awarded by JPB Foundation, The Principal Investigator 2021 - 2024
ASAP - Aligning Science Across Parkinson''s awarded by Michael J. Fox Foundation Principal Investigator 2021 - 2024
Addgene 706164 awarded by Addgene, Inc. Principal Investigator 2022 - 2023

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Background

education and training

M.D., Weill Cornell Medical College, Cornell University 1995
Ph.D., The Rockefeller University 1993
A.B., Princeton University 1987

Contact

full name

Michael G Kaplitt

primary email

mik2002@med.cornell.edu

webpage

Clinical Profile

VIVO Weill Cornell Medical College

Michael G Kaplitt Professor of Neurological Surgery

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

webpage

Phone

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

webpage