Chen, Qiuying

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selected publications

A coordinated multiorgan metabolic response contributes to human mitochondrial myopathy. EMBO molecular medicine. 2023 Academic Article GET IT
Novel genetically engineered mouse models for clear cell renal cell carcinoma. Scientific reports. 2023 Academic Article GET IT
Distinct cAMP signaling microdomains differentially regulate melanosomal pH and pigmentation. The Journal of investigative dermatology. 2023 Academic Article GET IT
LKB1-Dependent Regulation of TPI1 Creates a Divergent Metabolic Liability between Human and Mouse Lung Adenocarcinoma. Cancer discovery. 2023 Academic Article GET IT
Excess folic acid intake increases DNA de novo point mutations. Cell discovery. 2023 Letter GET IT
Times cited: 5
Transcriptional and metabolic remodeling in clear cell renal cell carcinoma caused by ATF4 activation and the integrated stress response (ISR). Molecular carcinogenesis. 2022 Academic Article GET IT
Times cited: 2
Embryonic Hypotaurine Levels Contribute to Strain-Dependent Susceptibility in Mouse Models of Valproate-Induced Neural Tube Defects. Frontiers in cell and developmental biology. 2022 Academic Article GET IT
Times cited: 82
Mitochondrial Ndufa4l2 Enhances Deposition of Lipids and Expression of Ca9 in the TRACK Model of Early Clear Cell Renal Cell Carcinoma. Frontiers in oncology. 2021 Academic Article GET IT
Times cited: 242
A retinoic acid receptor β2 agonist protects against alcohol liver disease and modulates hepatic expression of canonical retinoid metabolism genes. BioFactors (Oxford, England). 2021 Academic Article GET IT
Times cited: 1
Kidney Allograft Function Is a Confounder of Urine Metabolite Profiles in Kidney Allograft Recipients. Metabolites. 2021 Academic Article GET IT
Times cited: 974
Measurement of Melanin Metabolism in Live Cells by [U-¹³C]-L-Tyrosine Fate Tracing Using Liquid Chromatography-Mass Spectrometry. The Journal of investigative dermatology. 2021 Academic Article GET IT
Times cited: 8
Exogenous and Endogenous Sources of Serine Contribute to Colon Cancer Metabolism, Growth, and Resistance to 5-Fluorouracil. Cancer research. 2021 Academic Article GET IT
Times cited: 40
MiR-302 Regulates Glycolysis to Control Cell-Cycle during Neural Tube Closure. International journal of molecular sciences. 2020 Academic Article GET IT
Times cited: 8
Accelerated transsulfuration metabolically defines a discrete subclass of amyotrophic lateral sclerosis patients. Neurobiology of disease. 2020 Academic Article GET IT
Times cited: 9
Maternal Programming of Social Dominance via Milk Cytokines. iScience. 2020 Academic Article GET IT
Times cited: 5
APOE4 is Associated with Differential Regional Vulnerability to Bioenergetic Deficits in Aged APOE Mice. Scientific reports. 2020 Academic Article GET IT
Times cited: 25
CD73 Blockade Promotes Dendritic Cell Infiltration of Irradiated Tumors and Tumor Rejection. Cancer immunology research. 2020 Academic Article GET IT
Times cited: 69
Combined Metabolomics and Genome-Wide Transcriptomics Analyses Show Multiple HIF1α-Induced Changes in Lipid Metabolism in Early Stage Clear Cell Renal Cell Carcinoma. Translational oncology. 2019 Academic Article GET IT
Times cited: 20
High-fructose corn syrup enhances intestinal tumor growth in mice. Science (New York, N.Y.). 2019 Academic Article GET IT
Times cited: 176
Rewiring of Glutamine Metabolism Is a Bioenergetic Adaptation of Human Cells with Mitochondrial DNA Mutations. Cell metabolism. 2018 Academic Article GET IT
Times cited: 105
Partitioning of One-Carbon Units in Folate and Methionine Metabolism Is Essential for Neural Tube Closure. Cell reports. 2017 Academic Article GET IT
Times cited: 58
Neuronal hyperactivity due to loss of inhibitory tone in APOE4 mice lacking Alzheimer's disease-like pathology. Nature communications. 2017 Academic Article GET IT
Times cited: 88
Metabolite profiling of whole murine embryos reveals metabolic perturbations associated with maternal valproate-induced neural tube closure defects. Birth defects research. 2017 Academic Article GET IT
Times cited: 11
Reversible methylation of m⁶A_m in the 5' cap controls mRNA stability. Nature. 2016 Academic Article GET IT
Times cited: 660
Behavioural traits propagate across generations via segregated iterative-somatic and gametic epigenetic mechanisms. Nature communications. 2016 Academic Article GET IT
Times cited: 23
Smoking-Associated Disordering of the Airway Basal Stem/Progenitor Cell Metabotype. American journal of respiratory cell and molecular biology. 2016 Academic Article GET IT
Times cited: 26
Serum Metabolite Biomarkers Discriminate Healthy Smokers from COPD Smokers. PloS one. 2015 Academic Article GET IT
Times cited: 38
Untargeted metabolite profiling reveals that nitric oxide bioynthesis is an endogenous modulator of carotenoid biosynthesis in Deinococcus radiodurans and is required for extreme ionizing radiation resistance. Archives of biochemistry and biophysics. 2015 Academic Article GET IT
Times cited: 13
Urine Metabolite Profiles Predictive of Human Kidney Allograft Status. Journal of the American Society of Nephrology : JASN. 2015 Academic Article GET IT
Times cited: 49
Analyses of the transcriptome and metabolome demonstrate that HIF1α mediates altered tumor metabolism in clear cell renal cell carcinoma. PloS one. 2015 Academic Article GET IT
Times cited: 25
Untargeted metabolite profiling of murine embryos to reveal metabolic perturbations associated with neural tube closure defects. Birth defects research. Part A, Clinical and molecular teratology. 2014 Academic Article GET IT
Times cited: 11
Huntingtin protein is essential for mitochondrial metabolism, bioenergetics and structure in murine embryonic stem cells. Developmental biology. 2014 Academic Article GET IT
Times cited: 53
KCNQ1, KCNE2, and Na+-coupled solute transporters form reciprocally regulating complexes that affect neuronal excitability. Science signaling. 2014 Academic Article GET IT
Times cited: 51
Unbiased metabolite profiling indicates that a diminished thymidine pool is the underlying mechanism of colon cancer chemoprevention by alpha-difluoromethylornithine. Cancer discovery. 2013 Academic Article GET IT
Times cited: 39
Glutamine supplementation alleviates vasculopathy and corrects metabolic profile in an in vivo model of endothelial cell dysfunction. PloS one. 2013 Academic Article GET IT
Times cited: 21
Untargeted plasma metabolite profiling reveals the broad systemic consequences of xanthine oxidoreductase inactivation in mice. PloS one. 2012 Academic Article GET IT
Times cited: 42
A transgenic mouse model expressing exclusively human hemoglobin E: indications of a mild oxidative stress. Blood cells, molecules & diseases. 2012 Academic Article GET IT
Times cited: 8
Discovery and biological characterization of 1-(1H-indol-3-yl)-9H-pyrido[3,4-b]indole as an aryl hydrocarbon receptor activator generated by photoactivation of tryptophan by sunlight. Chemico-biological interactions. 2011 Academic Article GET IT
Times cited: 17
Structural and functional studies indicating altered redox properties of hemoglobin E: implications for production of bioactive nitric oxide. The Journal of biological chemistry. 2011 Academic Article GET IT
Times cited: 20
Human and mouse hemoglobin association with the transgenic mouse erythrocyte membrane. FEBS letters. 2006 Academic Article GET IT
Times cited: 11
A direct and simultaneous detection of zinc protoporphyrin IX, free protoporphyrin IX, and fluorescent heme degradation product in red blood cell hemolysates. Free radical research. 2006 Academic Article GET IT
Times cited: 11
Liganded hemoglobin structural perturbations by the allosteric effector L35. Biophysical journal. 2004 Academic Article GET IT
Times cited: 24
Liquid-liquid phase separation in hemoglobins: distinct aggregation mechanisms of the beta6 mutants. Biophysical journal. 2004 Academic Article GET IT
Times cited: 54
Generation of transgenic mice expressing human hemoglobin E. Blood cells, molecules & diseases. 2004 Academic Article GET IT
Times cited: 11
Beta7E-beta132K salt bridge and sickle haemoglobin stability and conformation. British journal of haematology. 2003 Academic Article GET IT
Times cited: 1
Distinct domain responses of R-state human hemoglobins A, C, and S to anions. Blood cells, molecules & diseases. 2002 Academic Article GET IT
Times cited: 5
Autoimmune hypogonadism as part of an autoimmune polyglandular syndrome. Journal of the Society for Gynecologic Investigation. 2001 Review GET IT
Times cited: 52
A novel mimetic enzymatic fluorescence immunoassay for hepatitis B surface antigen by using a thermal phase separating polymer. The Analyst. 2000 Academic Article GET IT
Times cited: 10
A novel method for the determination of total protein in human serum by near infrared fluorescence recovery. Fresenius' journal of analytical chemistry. 2000 Academic Article GET IT
Times cited: 16
Determination of proteins at nanogram levels by their quenching effect on large particle scattering of colloidal silver chloride. Fresenius' journal of analytical chemistry. 2000 Academic Article GET IT
Times cited: 22
Application of magdala red as a fluorescence probe in the determination of nucleic acids. Fresenius' journal of analytical chemistry. 2000 Academic Article GET IT
Times cited: 23
Determination of gaseous acidic compounds by measuring fluorescence after their reaction with tetra-substituted amino aluminum phthalocyanine. Talanta. 1999 Academic Article GET IT
Interaction of a novel red-region fluorescent probe, Nile blue, with DNA and its application to nucleic acids assay. The Analyst. 1999 Academic Article GET IT
Times cited: 142

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Research

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Funding awarded

Pho-m6A assay: A phosphoselective method to quantify dynamics of m6A in mRNA awarded by National Institute of Environmental Health Sciences Principal Investigator 2020 - 2023

Mechanisms Of Camp-Dependent Regulation Of Melanosome Ph awarded by National Inst of Arthritis & Musculoskeletal & Skin Diseases Co-Investigator 2021 - 2026
Pre-malignant mutation landscape and risk factors for progression to hematologic cancers awarded by National Cancer Institute Co-Investigator 2021 - 2026
Dissecting the Cellular and Molecular Links Between Atrial Fibrillation and Obesity awarded by American Heart Association Co-Investigator 2022 - 2025
Metabolic origin of oxidative stress injury in brain ischemia/reperfusion awarded by National Institute of Neurological Disorders & Stroke Co-Investigator 2022 - 2024

Metabolic remodeling of skeletal muscle in mitochondrial myopathies awarded by National Inst of Arthritis & Musculoskeletal & Skin Diseases Key Personnel 2020 - 2025
Modulation Of Intermediate Metabolism, A New Therapeutic Approach For Mitochondrial Encephalomyopathies awarded by National Institute of Neurological Disorders & Stroke Key Personnel 2021 - 2023

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Background

education and training

Ph.D., Xiamen University (China) 1999
M.S., Central South University (China) 1996
B.S., Central South University (China) 1993

Contact

full name

Qiuying Chen

primary email

qic2005@med.cornell.edu

VIVO Weill Cornell Medical College

Qiuying Chen Associate Professor of Research in Pharmacology

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

Phone

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email