Ehrt, Sabine

Publications

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selected publications

Metabolically distinct roles of NAD synthetase and NAD kinase define the essentiality of NAD and NADP in Mycobacterium tuberculosis. mBio. 2023 Academic Article GET IT
Synthetic lethality of Mycobacterium tuberculosis NADH dehydrogenases is due to impaired NADH oxidation. bioRxiv : the preprint server for biology. 2023 Article GET IT
Cyclic AMP is a critical mediator of intrinsic drug resistance and fatty acid metabolism in M. tuberculosis. eLife. 2023 Academic Article GET IT
Times cited: 55
A periplasmic cinched protein is required for siderophore secretion and virulence of Mycobacterium tuberculosis. Nature communications. 2022 Academic Article GET IT
Times cited: 2
CinA mediates multidrug tolerance in Mycobacterium tuberculosis. Nature communications. 2022 Academic Article GET IT
Times cited: 7
Chemical-genetic interaction mapping links carbon metabolism and cell wall structure to tuberculosis drug efficacy. Proceedings of the National Academy of Sciences of the United States of America. 2022 Academic Article GET IT
Times cited: 13
Host-pathogen genetic interactions underlie tuberculosis susceptibility in genetically diverse mice. eLife. 2022 Academic Article GET IT
Times cited: 14
Multiple acyl-CoA dehydrogenase deficiency kills Mycobacterium tuberculosis in vitro and during infection. Nature communications. 2021 Academic Article GET IT
Times cited: 9
Multiform antimicrobial resistance from a metabolic mutation. Science advances. 2021 Academic Article GET IT
Times cited: 14
Growth of Mycobacterium tuberculosis at acidic pH depends on lipid assimilation and is accompanied by reduced GAPDH activity. Proceedings of the National Academy of Sciences of the United States of America. 2021 Academic Article GET IT
Times cited: 21
Genome-wide gene expression tuning reveals diverse vulnerabilities of M. tuberculosis. Cell. 2021 Academic Article GET IT
Times cited: 67
Genetic models of latent tuberculosis in mice reveal differential influence of adaptive immunity. The Journal of experimental medicine. 2021 Academic Article GET IT
Times cited: 4
Metabolic bifunctionality of Rv0812 couples folate and peptidoglycan biosynthesis in Mycobacterium tuberculosis. The Journal of experimental medicine. 2021 Academic Article GET IT
Times cited: 3
Rv0954 Is a Member of the Mycobacterial Cell Division Complex. Frontiers in microbiology. 2021 Academic Article GET IT
Times cited: 37
Nonredundant functions of Mycobacterium tuberculosis chaperones promote survival under stress. Molecular microbiology. 2020 Academic Article GET IT
Times cited: 10
Mycobacterium tuberculosis infection is exacerbated in mice lacking lecithin:retinol acyltransferase. Biochimica et biophysica acta. Molecular basis of disease. 2020 Academic Article GET IT
Times cited: 1
Depletion of the DarG antitoxin in Mycobacterium tuberculosis triggers the DNA-damage response and leads to cell death. Molecular microbiology. 2020 Academic Article GET IT
Times cited: 15
Two interacting ATPases protect Mycobacterium tuberculosis from glycerol and nitric oxide toxicity. Journal of bacteriology. 2020 Academic Article GET IT
Times cited: 3
Tissue Distribution of Doxycycline in Animal Models of Tuberculosis. Antimicrobial agents and chemotherapy. 2020 Academic Article GET IT
Times cited: 15
Peptidoglycan Hydrolases RipA and Ami1 Are Critical for Replication and Persistence of Mycobacterium tuberculosis in the Host. mBio. 2020 Academic Article GET IT
Times cited: 24
Persistent Mycobacterium tuberculosis infection in mice requires PerM for successful cell division. eLife. 2019 Academic Article GET IT
Times cited: 10
Statistical analysis of variability in TnSeq data across conditions using zero-inflated negative binomial regression. BMC bioinformatics. 2019 Academic Article GET IT
Times cited: 11
Plasticity of the Mycobacterium tuberculosis respiratory chain and its impact on tuberculosis drug development. Nature communications. 2019 Academic Article GET IT
Times cited: 57
Mycobacterium tuberculosis releases an antacid that remodels phagosomes. Nature chemical biology. 2019 Academic Article GET IT
Times cited: 34
Transient drug-tolerance and permanent drug-resistance rely on the trehalose-catalytic shift in Mycobacterium tuberculosis. Nature communications. 2019 Academic Article GET IT
Times cited: 59
Large-scale chemical-genetics yields new M. tuberculosis inhibitor classes. Nature. 2019 Academic Article GET IT
Times cited: 85
Identification of Enolase as the Target of 2-Aminothiazoles in Mycobacterium tuberculosis. Frontiers in microbiology. 2018 Academic Article GET IT
Times cited: 143
Metabolic principles of persistence and pathogenicity in Mycobacterium tuberculosis. Nature reviews. Microbiology. 2018 Review GET IT
Times cited: 105
Targeting protein biotinylation enhances tuberculosis chemotherapy. Science translational medicine. 2018 Academic Article GET IT
Times cited: 21
Critical Impact of Peptidoglycan Precursor Amidation on the Activity of l,d-Transpeptidases from Enterococcus faecium and Mycobacterium tuberculosis. Chemistry (Weinheim an der Bergstrasse, Germany). 2018 Academic Article GET IT
Times cited: 26
Chemical Genetic Interaction Profiling Reveals Determinants of Intrinsic Antibiotic Resistance in Mycobacterium tuberculosis. Antimicrobial agents and chemotherapy. 2017 Academic Article GET IT
Times cited: 56
Distinct Spatiotemporal Dynamics of Peptidoglycan Synthesis between Mycobacterium smegmatis and Mycobacterium tuberculosis. mBio. 2017 Academic Article GET IT
Times cited: 33
Glyoxylate detoxification is an essential function of malate synthase required for carbon assimilation in Mycobacterium tuberculosis. Proceedings of the National Academy of Sciences of the United States of America. 2017 Academic Article GET IT
Times cited: 64
Fumarase Deficiency Causes Protein and Metabolite Succination and Intoxicates Mycobacterium tuberculosis. Cell chemical biology. 2017 Academic Article GET IT
Times cited: 34
PPE Surface Proteins Are Required for Heme Utilization by Mycobacterium tuberculosis. mBio. 2017 Academic Article GET IT
Times cited: 54
Comprehensive Essentiality Analysis of the Mycobacterium tuberculosis Genome via Saturating Transposon Mutagenesis. mBio. 2017 Academic Article GET IT
Times cited: 320
Mycobacterium tuberculosis protease MarP activates a peptidoglycan hydrolase during acid stress. The EMBO journal. 2017 Academic Article GET IT
Times cited: 32
Trehalose-6-Phosphate-Mediated Toxicity Determines Essentiality of OtsB2 in Mycobacterium tuberculosis In Vitro and in Mice. PLoS pathogens. 2016 Academic Article GET IT
Times cited: 25
A broader spectrum of tuberculosis. Nature medicine. 2016 Comment GET IT
Times cited: 12
Validation of CoaBC as a Bactericidal Target in the Coenzyme A Pathway of Mycobacterium tuberculosis. ACS infectious diseases. 2016 Academic Article GET IT
Times cited: 49
Mycobacterium tuberculosis Thioredoxin Reductase Is Essential for Thiol Redox Homeostasis but Plays a Minor Role in Antioxidant Defense. PLoS pathogens. 2016 Academic Article GET IT
Times cited: 42
Correction: LprG-Mediated Surface Expression of Lipoarabinomannan Is Essential for Virulence of Mycobacterium tuberculosis. PLoS pathogens. 2015 Article GET IT
Times cited: 72
Two enzymes with redundant fructose bisphosphatase activity sustain gluconeogenesis and virulence in Mycobacterium tuberculosis. Nature communications. 2015 Academic Article GET IT
Times cited: 42
Surface hydrolysis of sphingomyelin by the outer membrane protein Rv0888 supports replication of Mycobacterium tuberculosis in macrophages. Molecular microbiology. 2015 Academic Article GET IT
Times cited: 50
Identification of Rv3852 as an Agrimophol-Binding Protein in Mycobacterium tuberculosis. PloS one. 2015 Academic Article GET IT
Times cited: 15
Mycobacterial genes essential for the pathogen's survival in the host. Immunological reviews. 2015 Review GET IT
Times cited: 40
Disruption of an M. tuberculosis membrane protein causes a magnesium-dependent cell division defect and failure to persist in mice. PLoS pathogens. 2015 Academic Article GET IT
Times cited: 26
Construction of conditional knockdown mutants in mycobacteria. Methods in molecular biology (Clifton, N.J.). 2015 Academic Article GET IT
Times cited: 33
Target-based screen against a periplasmic serine protease that regulates intrabacterial pH homeostasis in Mycobacterium tuberculosis. ACS chemical biology. 2014 Academic Article GET IT
Times cited: 25
LprG-mediated surface expression of lipoarabinomannan is essential for virulence of Mycobacterium tuberculosis. PLoS pathogens. 2014 Academic Article GET IT
Times cited: 72
Inactivation of fructose-1,6-bisphosphate aldolase prevents optimal co-catabolism of glycolytic and gluconeogenic carbon substrates in Mycobacterium tuberculosis. PLoS pathogens. 2014 Academic Article GET IT
Times cited: 56
Triosephosphate isomerase is dispensable in vitro yet essential for Mycobacterium tuberculosis to establish infection. mBio. 2014 Academic Article GET IT
Times cited: 38
An outer membrane channel protein of Mycobacterium tuberculosis with exotoxin activity. Proceedings of the National Academy of Sciences of the United States of America. 2014 Academic Article GET IT
Times cited: 89
Regulated Expression Systems for Mycobacteria and Their Applications. Microbiology spectrum. 2014 Review GET IT
Times cited: 35
Regulated Expression Systems for Mycobacteria and Their Applications. Microbiology spectrum. 2014 Academic Article GET IT
A genetic strategy to identify targets for the development of drugs that prevent bacterial persistence. Proceedings of the National Academy of Sciences of the United States of America. 2013 Academic Article GET IT
Times cited: 104
Perturbation of cytochrome c maturation reveals adaptability of the respiratory chain in Mycobacterium tuberculosis. mBio. 2013 Academic Article GET IT
Times cited: 56
Whole cell screen for inhibitors of pH homeostasis in Mycobacterium tuberculosis. PloS one. 2013 Academic Article GET IT
Times cited: 55
Substrate specificity of MarP, a periplasmic protease required for resistance to acid and oxidative stress in Mycobacterium tuberculosis. The Journal of biological chemistry. 2013 Academic Article GET IT
Times cited: 24
Glucose phosphorylation is required for Mycobacterium tuberculosis persistence in mice. PLoS pathogens. 2013 Academic Article GET IT
Times cited: 85
Mycobacterium tuberculosis metabolism and host interaction: mysteries and paradoxes. Current topics in microbiology and immunology. 2013 Review GET IT
Times cited: 49
Mycobacterial trehalose dimycolate reprograms macrophage global gene expression and activates matrix metalloproteinases. Infection and immunity. 2012 Academic Article GET IT
Times cited: 35
Detection and treatment of subclinical tuberculosis. Tuberculosis (Edinburgh, Scotland). 2012 Academic Article GET IT
Times cited: 30
M. tuberculosis induces potent activation of IDO-1, but this is not essential for the immunological control of infection. PloS one. 2012 Academic Article GET IT
Times cited: 65
Evaluating the sensitivity of Mycobacterium tuberculosis to biotin deprivation using regulated gene expression. PLoS pathogens. 2011 Academic Article GET IT
Times cited: 116
Glycolytic and non-glycolytic functions of Mycobacterium tuberculosis fructose-1,6-bisphosphate aldolase, an essential enzyme produced by replicating and non-replicating bacilli. The Journal of biological chemistry. 2011 Academic Article GET IT
Times cited: 67
Mycobacterium tuberculosis gene Rv2136c is dispensable for acid resistance and virulence in mice. Tuberculosis (Edinburgh, Scotland). 2011 Academic Article GET IT
Times cited: 6
Central carbon metabolism in Mycobacterium tuberculosis: an unexpected frontier. Trends in microbiology. 2011 Academic Article GET IT
Times cited: 126
Phosphodiesterase 4 inhibition reduces innate immunity and improves isoniazid clearance of Mycobacterium tuberculosis in the lungs of infected mice. PloS one. 2011 Academic Article GET IT
Times cited: 57
Virulence of Mycobacterium tuberculosis depends on lipoamide dehydrogenase, a member of three multienzyme complexes. Cell host & microbe. 2011 Academic Article GET IT
Times cited: 96
Simultaneous analysis of multiple Mycobacterium tuberculosis knockdown mutants in vitro and in vivo. PloS one. 2010 Academic Article GET IT
Times cited: 57
Metabolomics of Mycobacterium tuberculosis reveals compartmentalized co-catabolism of carbon substrates. Chemistry & biology. 2010 Academic Article GET IT
Times cited: 279
Nitrate respiration protects hypoxic Mycobacterium tuberculosis against acid- and reactive nitrogen species stresses. PloS one. 2010 Academic Article GET IT
Times cited: 84
Structural insight into serine protease Rv3671c that Protects M. tuberculosis from oxidative and acidic stress. Structure (London, England : 1993). 2010 Academic Article GET IT
Times cited: 28
Induction of ER stress in macrophages of tuberculosis granulomas. PloS one. 2010 Academic Article GET IT
Times cited: 106
The Mycobacterium tuberculosis proteasome active site threonine is essential for persistence yet dispensable for replication and resistance to nitric oxide. PLoS pathogens. 2010 Academic Article GET IT
Times cited: 74
Gluconeogenic carbon flow of tricarboxylic acid cycle intermediates is critical for Mycobacterium tuberculosis to establish and maintain infection. Proceedings of the National Academy of Sciences of the United States of America. 2010 Academic Article GET IT
Times cited: 269
The spectrum of latent tuberculosis: rethinking the biology and intervention strategies. Nature reviews. Microbiology. 2009 Review GET IT
Times cited: 1022
Acid resistance in Mycobacterium tuberculosis. Journal of bacteriology. 2009 Review GET IT
Times cited: 176
Mycobacterial survival strategies in the phagosome: defence against host stresses. Cellular microbiology. 2009 Review GET IT
Times cited: 315
Improved tetracycline repressors for gene silencing in mycobacteria. Nucleic acids research. 2009 Academic Article GET IT
Times cited: 77
RP105 facilitates macrophage activation by Mycobacterium tuberculosis lipoproteins. Cell host & microbe. 2009 Academic Article GET IT
Times cited: 47
Acid-susceptible mutants of Mycobacterium tuberculosis share hypersusceptibility to cell wall and oxidative stress and to the host environment. Journal of bacteriology. 2008 Academic Article GET IT
Times cited: 120
Sabine Ehrt: searching for mycobacterial stress points. Interview by Hema Bashyam. The Journal of experimental medicine. 2008 Article GET IT
A membrane protein preserves intrabacterial pH in intraphagosomal Mycobacterium tuberculosis. Nature medicine. 2008 Academic Article GET IT
Times cited: 257
Biosynthesis and recycling of nicotinamide cofactors in mycobacterium tuberculosis. An essential role for NAD in nonreplicating bacilli. The Journal of biological chemistry. 2008 Academic Article GET IT
Times cited: 131
Selective killing of nonreplicating mycobacteria. Cell host & microbe. 2008 Academic Article GET IT
Times cited: 151
In vivo gene silencing identifies the Mycobacterium tuberculosis proteasome as essential for the bacteria to persist in mice. Nature medicine. 2007 Academic Article GET IT
Times cited: 205
Nucleotide-binding oligomerization domain protein 2-deficient mice control infection with Mycobacterium tuberculosis. Infection and immunity. 2007 Academic Article GET IT
Times cited: 89
Mycobacterial nonhomologous end joining mediates mutagenic repair of chromosomal double-strand DNA breaks. Journal of bacteriology. 2007 Academic Article GET IT
Times cited: 76
Silencing Mycobacterium smegmatis by using tetracycline repressors. Journal of bacteriology. 2007 Academic Article GET IT
Times cited: 93
Mycobacterium tuberculosis virulence: lipids inside and out. Nature medicine. 2007 Article GET IT
Times cited: 47
Controlling gene expression in mycobacteria. Future microbiology. 2006 Review GET IT
Times cited: 24
Cytosolic phospholipase A2 enzymes are not required by mouse bone marrow-derived macrophages for the control of Mycobacterium tuberculosis in vitro. Infection and immunity. 2006 Academic Article GET IT
Times cited: 14
Introduction: genomic approaches in infectious diseases. Microbes and infection. 2006 Editorial Article GET IT
Expression profiling of host pathogen interactions: how Mycobacterium tuberculosis and the macrophage adapt to one another. Microbes and infection. 2006 Review GET IT
Times cited: 40
Dihydrolipoamide acyltransferase is critical for Mycobacterium tuberculosis pathogenesis. Infection and immunity. 2006 Academic Article GET IT
Times cited: 74
Induction of macrophage-derived SLPI by Mycobacterium tuberculosis depends on TLR2 but not MyD88. Immunology. 2005 Academic Article GET IT
Times cited: 27
Protection from Alzheimer's-like disease in the mouse by genetic ablation of inducible nitric oxide synthase. The Journal of experimental medicine. 2005 Academic Article GET IT
Times cited: 173
Expression of many immunologically important genes in Mycobacterium tuberculosis-infected macrophages is independent of both TLR2 and TLR4 but dependent on IFN-alphabeta receptor and STAT1. Journal of immunology (Baltimore, Md. : 1950). 2005 Academic Article GET IT
Times cited: 84
Ancestral antibiotic resistance in Mycobacterium tuberculosis. Proceedings of the National Academy of Sciences of the United States of America. 2005 Academic Article GET IT
Times cited: 241
A glutamate-alanine-leucine (EAL) domain protein of Salmonella controls bacterial survival in mice, antioxidant defence and killing of macrophages: role of cyclic diGMP. Molecular microbiology. 2005 Academic Article GET IT
Times cited: 118
Controlling gene expression in mycobacteria with anhydrotetracycline and Tet repressor. Nucleic acids research. 2005 Academic Article GET IT
Times cited: 276
The proteasome of Mycobacterium tuberculosis is required for resistance to nitric oxide. Science (New York, N.Y.). 2003 Academic Article GET IT
Times cited: 427
Hypervirulent mutant of Mycobacterium tuberculosis resulting from disruption of the mce1 operon. Proceedings of the National Academy of Sciences of the United States of America. 2003 Academic Article GET IT
Times cited: 175
MyD88 primes macrophages for full-scale activation by interferon-gamma yet mediates few responses to Mycobacterium tuberculosis. The Journal of experimental medicine. 2003 Academic Article GET IT
Times cited: 123
Transcriptional Adaptation of Mycobacterium tuberculosis within Macrophages: Insights into the Phagosomal Environment. The Journal of experimental medicine. 2003 Academic Article GET IT
Times cited: 1161
Isolation of plasmids from E. coli by alkaline lysis. Methods in molecular biology (Clifton, N.J.). 2003 Academic Article GET IT
Times cited: 20
Isolation of plasmids from E. coli by boiling lysis. Methods in molecular biology (Clifton, N.J.). 2003 Academic Article GET IT
Times cited: 4
Energy transfer between fluorescent proteins using a co-expression system in Mycobacterium smegmatis. Gene. 2001 Academic Article GET IT
Times cited: 53
Reprogramming of the macrophage transcriptome in response to interferon-gamma and Mycobacterium tuberculosis: signaling roles of nitric oxide synthase-2 and phagocyte oxidase. The Journal of experimental medicine. 2001 Academic Article GET IT
Times cited: 401
Recombinant Mycobacterium tuberculosis protein associated with mammalian cell entry. Cellular microbiology. 2001 Academic Article GET IT
Times cited: 131
Plasmid vectors. Methods in molecular medicine. 2001 Academic Article GET IT
A parallel intraphagosomal survival strategy shared by mycobacterium tuberculosis and Salmonella enterica. Molecular microbiology. 2000 Academic Article GET IT
Times cited: 125
Deletion of the putative antioxidant noxR1 does not alter the virulence of Mycobacterium tuberculosis H37Rv. Tubercle and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease. 2000 Academic Article GET IT
Times cited: 8
Cloning of the mspA gene encoding a porin from Mycobacterium smegmatis. Molecular microbiology. 1999 Academic Article GET IT
Times cited: 128
noxR3, a novel gene from Mycobacterium tuberculosis, protects Salmonella typhimurium from nitrosative and oxidative stress. Infection and immunity. 1999 Academic Article GET IT
Times cited: 53
A novel antioxidant gene from Mycobacterium tuberculosis. The Journal of experimental medicine. 1997 Academic Article GET IT
Times cited: 91
Expression, inducer spectrum, domain structure, and function of MopR, the regulator of phenol degradation in Acinetobacter calcoaceticus NCIB8250. Journal of bacteriology. 1997 Academic Article GET IT
Times cited: 104
Genetic organization, nucleotide sequence and regulation of expression of genes encoding phenol hydroxylase and catechol 1,2-dioxygenase in Acinetobacter calcoaceticus NCIB8250. Molecular microbiology. 1995 Academic Article GET IT
Times cited: 83
Two genes encoding proteins with similarities to rubredoxin and rubredoxin reductase are required for conversion of dodecane to lauric acid in Acinetobacter calcoaceticus ADP1. Microbiology (Reading, England). 1995 Academic Article GET IT
Times cited: 32
RpoN (sigma 54) is required for conversion of phenol to catechol in Acinetobacter calcoaceticus. Journal of bacteriology. 1994 Academic Article GET IT
Times cited: 21
UDP-N-acetylglucosamine 1-carboxyvinyl-transferase from Acinetobacter calcoaceticus. FEMS microbiology letters. 1994 Academic Article GET IT
Times cited: 3

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Research

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Co-investigator Network

Funding awarded

Determinants of TB control, relapse and reinfection awarded by National Institute of Allergy & Infectious Diseases Principal Investigator 2021 - 2026
Pathway Analysis in Tuberculosis awarded by National Institute of Allergy & Infectious Diseases Principal Investigator 2020 - 2025
Immunology and Microbial Pathogenesis Research Training Program awarded by National Institute of Allergy & Infectious Diseases Principal Investigator 2019 - 2024
Conditional Expression of Mycobacterial Genes awarded by National Institute of Allergy & Infectious Diseases Principal Investigator 2018 - 2024
Conditionally Replicating Mycobacterium Tuberculosis Vaccines awarded by National Institute of Allergy & Infectious Diseases Principal Investigator 2018 - 2024

The Transmission Biology of Mycobacterium Tuberculosis awarded by National Institute of Allergy & Infectious Diseases Co-Investigator 2021 - 2026
Chemical Genomics of Tuberculosis awarded by Bill & Melinda Gates Foundation Co-Investigator 2022 - 2025
Determination of the mode of action of the antibiotic pyrazinamide awarded by National Institute of Allergy & Infectious Diseases Co-Investigator 2022 - 2024
Turning Mycobacterium tuberculosis appetite for fatty acids against itself awarded by National Institute of Allergy & Infectious Diseases Co-Investigator 2022 - 2024
Conditional M. tuberculosis knockdown mutants for TB drug discovery (INV-004761) awarded by Bill & Melinda Gates Foundation Co-Investigator 2020 - 2023

Tri-Institutional Tuberculosis Research Advancement Center awarded by National Institute of Allergy & Infectious Diseases Key Personnel 2022 - 2027
Investigating genetic regulators of Mycobacterium tuberculosis cell division and their role in persistent tuberculosis infection awarded by National Institute of Allergy & Infectious Diseases Key Personnel 2022 - 2024
Ironing out mycobacterial persistence: Iron access and utilization in chronic mycobacterial infection awarded by National Heart, Lung, & Blood Institute Key Personnel 2020 - 2024
Defining Mycobacterium tuberculosis as a lung pathobiont awarded by National Science Foundation Key Personnel 2020 - 2023

Harnessing B Cells For TB Vaccine Development To Improve Therapy Of TB And TB-HIV Coinfection awarded by National Institute of Allergy & Infectious Diseases Principal Investigator Subaward 2021 - 2026
Development of a self inactivating, highly effective TB vaccine awarded by National Institute of Allergy & Infectious Diseases Principal Investigator Subaward 2019 - 2024

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Background

education and training

Ph.D., University of Erlangen (Germany) 1994

Contact

full name

Sabine Ehrt

primary email

sae2004@med.cornell.edu

VIVO Weill Cornell Medical College

Sabine Ehrt Professor of Microbiology and Immunology

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

Phone

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email