The control of release probability at nerve terminals. Review uri icon

Overview

abstract

  • Exocytosis is a fundamental membrane fusion process by which the soluble or membrane-associated cargoes of a secretory vesicle are delivered to the extracellular milieu or the cell surface. While essential for all organs, the brain relies on a specialized form of exocytosis to mediate information flow throughout its vast circuitry. Neurotransmitter-laden synaptic vesicles fuse with the plasma membrane on cue with astonishing speed in a probabilistic process that is both tightly regulated and capable of a fascinating array of plasticities. Here, we examine progress in the molecular understanding of synaptic vesicle fusion and its control.

publication date

  • March 1, 2019

Research

keywords

  • Exocytosis
  • Neurons
  • Presynaptic Terminals
  • Synaptic Transmission
  • Synaptic Vesicles

Identity

Scopus Document Identifier

  • 85060174212

Digital Object Identifier (DOI)

  • 10.1007/s00232-004-0669-8

PubMed ID

  • 30647451

Additional Document Info

volume

  • 20

issue

  • 3