Biochemistry

publication venue for

The Crystal Structure of Dph2 in Complex with Elongation Factor 2 Reveals the Structural Basis for the First Step of Diphthamide Biosynthesis.. 58. 2019
Redox Sensing by PecS from the Plant Pathogen Pectobacterium atrosepticum and Its Effect on Gene Expression and the Conformation of PecS-Bound Promoter DNA.. 58. 2019
Structure-Based Design, Synthesis, and Biological Evaluation of Non-Acyl Sulfamate Inhibitors of the Adenylate-Forming Enzyme MenE.. 58. 2019
Spectral Tuning by a Single Nucleotide Controls the Fluorescence Properties of a Fluorogenic Aptamer.. 58. 2019
The HIV gp41 Fusion Protein Inhibits T-Cell Activation through the Lentiviral Lytic Peptide 2 Motif.. 58. 2019
Kinetic Analyses of the Siderophore Biosynthesis Inhibitor Salicyl-AMS and Analogues as MbtA Inhibitors and Antimycobacterial Agents.. 58. 2019
An Open Library of Human Kinase Domain Constructs for Automated Bacterial Expression.. 57. 2018
Synthetic Analogues of the Snail Toxin 6-Bromo-2-mercaptotryptamine Dimer (BrMT) Reveal That Lipid Bilayer Perturbation Does Not Underlie Its Modulation of Voltage-Gated Potassium Channels.. 57. 2018
Crystal Structures of Cystathionine β-Synthase from Saccharomyces cerevisiae: One Enzymatic Step at a Time.. 57. 2018
The Stringent Response Induced by Phosphate Limitation Promotes Purine Salvage in Agrobacterium fabrum.. 56. 2017
Dss1 Regulates Association of Brh2 with Rad51.. 56. 2017
Structure Determination of Mycobacterium tuberculosis Serine Protease Hip1 (Rv2224c).. 56. 2017
Structural Basis for the Species-Selective Binding of N,C-Capped Dipeptides to the Mycobacterium tuberculosis Proteasome.. 56. 2016
Dynamics of Aromatic Side Chains in the Active Site of FKBP12.. 56. 2016
Incorporation of an Unnatural Amino Acid as a Domain-Specific Fluorescence Probe in a Two-Domain Protein.. 55. 2016
Neo High-Density Lipoprotein Produced by the Streptococcal Serum Opacity Factor Activity against Human High-Density Lipoproteins Is Hepatically Removed via Dual Mechanisms.. 55. 2016
Branched Fatty Acid Esters of Hydroxy Fatty Acids Are Preferred Substrates of the MODY8 Protein Carboxyl Ester Lipase.. 55. 2016
Identification of BECN1 and ATG14 Coiled-Coil Interface Residues That Are Important for Starvation-Induced Autophagy.. 55. 2016
Metal-Dependent Function of a Mammalian Acireductone Dioxygenase.. 55. 2016
Role of Annular Lipids in the Functional Properties of Leucine Transporter LeuT Proteomicelles.. 55. 2016
Mechanism of MenE inhibition by acyl-adenylate analogues and discovery of novel antibacterial agents.. 54. 2015
STARD4 Membrane Interactions and Sterol Binding.. 54. 2015
Apolipoprotein AI deficiency inhibits serum opacity factor activity against plasma high density lipoprotein via a stabilization mechanism.. 54. 2015
Conserved amino acid residues of the NuoD segment important for structure and function of Escherichia coli NDH-1 (complex I).. 54. 2015
Differential dynamics of extracellular and cytoplasmic domains in denatured States of rhodopsin.. 53. 2014
Identification of the GPR55 antagonist binding site using a novel set of high-potency GPR55 selective ligands.. 52. 2013
Lipoamide channel-binding sulfonamides selectively inhibit mycobacterial lipoamide dehydrogenase.. 52. 2013
Post-translational modification by cysteine protects Cu/Zn-superoxide dismutase from oxidative damage.. 52. 2013
Structural consequences of cysteinylation of Cu/Zn-superoxide dismutase.. 52. 2013
Free cholesterol determines reassembled high-density lipoprotein phospholipid phase structure and stability.. 52. 2013
Chemical catalysis by the translocator protein (18 kDa).. 52. 2013
A phenylalanine clamp controls substrate specificity in the quorum-quenching metallo-γ-lactonase from Bacillus thuringiensis.. 52. 2013
Proper protein glycosylation promotes mitogen-activated protein kinase signal fidelity.. 52. 2012
Characterization of Mycobacterium smegmatis PolD2 and PolD1 as RNA/DNA polymerases homologous to the POL domain of bacterial DNA ligase D.. 51. 2012
Dss1 release activates DNA binding potential in Brh2.. 51. 2012
Cholesterol determines and limits rHDL formation from human plasma apolipoprotein A-II and phospholipid membranes.. 51. 2012
Phosphatidylinositol 4,5-biphosphate (PIP(2)) lipids regulate the phosphorylation of syntaxin N-terminus by modulating both its position and local structure.. 51. 2012
Nanoscale structure and dynamics of ABOBEC3G complexes with single-stranded DNA.. 51. 2012
Specificity of binding of single-stranded DNA-binding protein to its target.. 51. 2012
A processive carbohydrate polymerase that mediates bifunctional catalysis using a single active site.. 51. 2012
Dynamics of nucleosomes assessed with time-lapse high-speed atomic force microscopy.. 50. 2011
Structural characterization of two alternate conformations in a calbindin D₉k-based molecular switch.. 50. 2011
The membrane interface dictates different anchor roles for "inner pair" and "outer pair" tryptophan indole rings in gramicidin A channels.. 50. 2011
Evidence of the participation of remote residues in the catalytic activity of Co-type nitrile hydratase from Pseudomonas putida.. 50. 2011
Prolyl isomerases show low sequence specificity toward the residue following the proline.. 50. 2011
Heparin binds 8 kDa gelsolin cross-β-sheet oligomers and accelerates amyloidogenesis by hastening fibril extension.. 50. 2011
Identification of a chemical that inhibits the mycobacterial UvrABC complex in nucleotide excision repair.. 50. 2011
Sulfated glycosaminoglycans accelerate transthyretin amyloidogenesis by quaternary structural conversion.. 50. 2011
Probing the structural determinants for the function of intracellular loop 2 in structurally cognate G-protein-coupled receptors.. 49. 2010
Speciated human high-density lipoprotein protein proximity profiles.. 49. 2010
Reconstitution of diphthine synthase activity in vitro.. 49. 2010
Streptococcal serum opacity factor increases the rate of hepatocyte uptake of human plasma high-density lipoprotein cholesterol.. 49. 2010
Polar groups in membrane channels: consequences of replacing alanines with serines in membrane-spanning gramicidin channels.. 49. 2010
Nitration of the tumor suppressor protein p53 at tyrosine 327 promotes p53 oligomerization and activation.. 49. 2010
Triazaspirodimethoxybenzoyls as selective inhibitors of mycobacterial lipoamide dehydrogenase .. 49. 2010
Dss1 regulates interaction of Brh2 with DNA.. 48. 2009
The 8 and 5 kDa fragments of plasma gelsolin form amyloid fibrils by a nucleated polymerization mechanism, while the 68 kDa fragment is not amyloidogenic.. 48. 2009
Apolipoprotein modulation of streptococcal serum opacity factor activity against human plasma high-density lipoproteins.. 48. 2009
Hydrogen bond coupling in the ketosteroid isomerase active site.. 48. 2009
Effects of pH and iminosugar pharmacological chaperones on lysosomal glycosidase structure and stability.. 48. 2009
The unfolded state of the C-terminal domain of the ribosomal protein L9 contains both native and non-native structure.. 48. 2009
Mapping protein-protein interactions by localized oxidation: consequences of the reach of hydroxyl radical.. 48. 2009
Stimulation of guanylyl cyclase-D by bicarbonate.. 48. 2009
Mutational analysis of Mycobacterium UvrD1 identifies functional groups required for ATP hydrolysis, DNA unwinding, and chemomechanical coupling.. 48. 2009
Snapshot of a reaction intermediate: analysis of benzoylformate decarboxylase in complex with a benzoylphosphonate inhibitor.. 48. 2009
Investigating the ADP-ribosyltransferase activity of sirtuins with NAD analogues and 32P-NAD.. 48. 2009
Structure of the HIV-1 gp41 membrane-proximal ectodomain region in a putative prefusion conformation.. 48. 2009
Disruption of human plasma high-density lipoproteins by streptococcal serum opacity factor requires labile apolipoprotein A-I.. 48. 2009
Detection and time course of formation of major thiamin diphosphate-bound covalent intermediates derived from a chromophoric substrate analogue on benzoylformate decarboxylase.. 48. 2009
Solution structure of the DNA binding domain of rice telomere binding protein RTBP1.. 48. 2009
Evolution reversed: the ability to bind iron restored to the N-lobe of the murine inhibitor of carbonic anhydrase by strategic mutagenesis.. 47. 2008
The low-pH unfolded state of the C-terminal domain of the ribosomal protein L9 contains significant secondary structure in the absence of denaturant but is no more compact than the low-pH urea unfolded state.. 47. 2008
Domain requirements for DNA unwinding by mycobacterial UvrD2, an essential DNA helicase.. 47. 2008
Mechanism of the quorum-quenching lactonase (AiiA) from Bacillus thuringiensis. 1. Product-bound structures.. 47. 2008
Mechanism of the quorum-quenching lactonase (AiiA) from Bacillus thuringiensis. 2. Substrate modeling and active site mutations.. 47. 2008
Distinct flippases translocate glycerophospholipids and oligosaccharide diphosphate dolichols across the endoplasmic reticulum.. 47. 2008
Zinc coordination geometry and ligand binding affinity: the structural and kinetic analysis of the second-shell serine 228 residue and the methionine 180 residue of the aminopeptidase from Vibrio proteolyticus.. 47. 2008
Probing the active center of benzaldehyde lyase with substitutions and the pseudosubstrate analogue benzoylphosphonic acid methyl ester.. 47. 2008
Active state-like conformational elements in the beta2-AR and a photoactivated intermediate of rhodopsin identified by dynamic properties of GPCRs.. 47. 2008
Trapping a folding intermediate of the alpha-helix: stabilization of the pi-helix.. 47. 2008
Serum opacity factor unmasks human plasma high-density lipoprotein instability via selective delipidation and apolipoprotein A-I desorption.. 46. 2007
Candida drug resistance protein 1, a major multidrug ATP binding cassette transporter of Candida albicans, translocates fluorescent phospholipids in a reconstituted system.. 46. 2007
Structural and thermodynamic characterization of the Escherichia coli RelBE toxin-antitoxin system: indication for a functional role of differential stability.. 46. 2007
Tyrosine nitration of IkappaBalpha: a novel mechanism for NF-kappaB activation.. 46. 2007
Structure and specificity of a quorum-quenching lactonase (AiiB) from Agrobacterium tumefaciens.. 46. 2007
Inactivation of Escherichia coli L-aspartate aminotransferase by (S)-4-amino-4,5-dihydro-2-thiophenecarboxylic acid reveals "a tale of two mechanisms".. 46. 2007
Curcumin is a modulator of bilayer material properties.. 46. 2007
Speciation of human plasma high-density lipoprotein (HDL): HDL stability and apolipoprotein A-I partitioning.. 46. 2007
The impact of the E46K mutation on the properties of alpha-synuclein in its monomeric and oligomeric states.. 46. 2007
DNA binding, annealing, and strand exchange activities of Brh2 protein from Ustilago maydis.. 46. 2007
Protein design of a bacterially expressed HIV-1 gp41 fusion inhibitor.. 46. 2007
Effects of glycine substitutions on the structure and function of gramicidin a channels.. 45. 2006
Detergent-mediated phospholipidation of plasma lipoproteins increases HDL cholesterophilicity and cholesterol efflux via SR-BI.. 45. 2006
Identification of the single specific IQ motif of myosin V from which calmodulin dissociates in the presence of Ca2+.. 45. 2006
Structures of biologically active oxysterols determine their differential effects on phospholipid membranes.. 45. 2006
Structural characterization of enterobactin hydrolase IroE.. 45. 2006
Spatial separation of beta-sheet domains of beta-amyloid: disruption of each beta-sheet by N-methyl amino acids.. 45. 2006
Cisplatin-induced toxicity is associated with platinum deposition in mouse kidney mitochondria in vivo and with selective inactivation of the alpha-ketoglutarate dehydrogenase complex in LLC-PK1 cells.. 45. 2006
Mutations in PRP43 that uncouple RNA-dependent NTPase activity and pre-mRNA splicing function.. 45. 2006
Hydration of the folding transition state ensemble of a protein.. 45. 2006
Csk mediates G-protein-coupled lysophosphatidic acid receptor-induced inhibition of membrane-bound guanylyl cyclase activity.. 45. 2006
Requirement of SRC-family tyrosine kinases in fat accumulation.. 44. 2005
Role of oxysterol structure on the microdomain-induced microsolubilization of phospholipid membranes by apolipoprotein A-I.. 44. 2005
ASF1 binds to a heterodimer of histones H3 and H4: a two-step mechanism for the assembly of the H3-H4 heterotetramer on DNA.. 44. 2005
Kinetic, spectroscopic, and X-ray crystallographic characterization of the functional E151H aminopeptidase from Aeromonas proteolytica.. 44. 2005
NMR investigation of main-chain dynamics of the H80E mutant of bovine neurophysin-I: demonstration of dimerization-induced changes at the hormone-binding site.. 44. 2005
Cyclostreptin (FR182877), an antitumor tubulin-polymerizing agent deficient in enhancing tubulin assembly despite its high affinity for the taxoid site.. 44. 2005
Phosphonate analogues of alpha-ketoglutarate inhibit the activity of the alpha-ketoglutarate dehydrogenase complex isolated from brain and in cultured cells.. 44. 2005
The polar nature of 7-ketocholesterol determines its location within membrane domains and the kinetics of membrane microsolubilization by apolipoprotein A-I.. 44. 2005
Characterization of the NTPase, RNA-binding, and RNA helicase activities of the DEAH-box splicing factor Prp22.. 44. 2005
Remodeling of human plasma lipoproteins by detergent perturbation.. 44. 2005
Transglutaminase activity is present in highly purified nonsynaptosomal mouse brain and liver mitochondria.. 44. 2005
Transport of newly synthesized sterol to the sterol-enriched plasma membrane occurs via nonvesicular equilibration.. 44. 2005
Residual structure in the repeat domain of tau: echoes of microtubule binding and paired helical filament formation.. 44. 2005
Plasma factors required for human apolipoprotein A-II dimerization.. 44. 2005
Chemical modification identifies two populations of glycerophospholipid flippase in rat liver ER.. 43. 2004
Crystal structure of 3-carboxy-cis,cis-muconate lactonizing enzyme from Pseudomonas putida, a fumarase class II type cycloisomerase: enzyme evolution in parallel pathways.. 43. 2004
A disubstituted succinamide is a potent sodium channel blocker with efficacy in a rat pain model.. 43. 2004
Spectroscopic and X-ray crystallographic characterization of bestatin bound to the aminopeptidase from Aeromonas (Vibrio) proteolytica.. 43. 2004
Properties of human vasopressin precursor constructs: inefficient monomer folding in the absence of copeptin as a potential contributor to diabetes insipidus.. 43. 2004
An encephalitozoon cuniculi ortholog of the RNA polymerase II carboxyl-terminal domain (CTD) serine phosphatase Fcp1.. 43. 2004
Xylose isomerase in substrate and inhibitor michaelis states: atomic resolution studies of a metal-mediated hydride shift.. 43. 2004
Effects of Parkinson's disease-linked mutations on the structure of lipid-associated alpha-synuclein.. 43. 2004
Correlation between catalytic efficiency and the transcription read-out in chemical complementation: a general assay for enzyme catalysis.. 43. 2004
Crystal structure at 1.8 A resolution of CDP-D-glucose 4,6-dehydratase from Yersinia pseudotuberculosis.. 43. 2004
Structural basis for differences in substrate selectivity in Kex2 and furin protein convertases.. 43. 2004
Structure of triglyceride-rich human low-density lipoproteins according to cryoelectron microscopy.. 42. 2003
Genistein can modulate channel function by a phosphorylation-independent mechanism: importance of hydrophobic mismatch and bilayer mechanics.. 42. 2003
Trimeric subunit stoichiometry of the glutamate transporters from Bacillus caldotenax and Bacillus stearothermophilus.. 42. 2003
Receptor-regulated dynamic interaction between endothelial nitric oxide synthase and calmodulin revealed by fluorescence resonance energy transfer in living cells.. 42. 2003
Electrostatic tuning of ion conductance in potassium channels.. 42. 2003
2.4 A resolution crystal structure of the prototypical hormone-processing protease Kex2 in complex with an Ala-Lys-Arg boronic acid inhibitor.. 42. 2003
A second site rescue mutation partially restores functional expression to the serotonin transporter mutant V382P.. 42. 2003
Galactose mutarotase: pH dependence of enzymatic mutarotation.. 42. 2003
Structural and functional determinants of human plasma phospholipid transfer protein activity as revealed by site-directed mutagenesis of charged amino acids.. 42. 2003
The structure, cation binding, transport, and conductance of Gly15-gramicidin A incorporated into SDS micelles and PC/PG vesicles.. 42. 2003
The immunosuppressive agent mizoribine monophosphate forms a transition state analogue complex with inosine monophosphate dehydrogenase.. 42. 2003
Crystal structure of a ternary complex of Tritrichomonas foetus inosine 5'-monophosphate dehydrogenase: NAD+ orients the active site loop for catalysis.. 41. 2002
Reconstitution and characterization of the human DNA polymerase delta four-subunit holoenzyme.. 41. 2002
The local environment at the cytoplasmic end of TM6 of the mu opioid receptor differs from those of rhodopsin and monoamine receptors: introduction of an ionic lock between the cytoplasmic ends of helices 3 and 6 by a L6.30(275)E mutation inactivates the mu opioid receptor and reduces the constitutive activity of its T6.34(279)K mutant.. 41. 2002
The microtubule stabilizing agent laulimalide does not bind in the taxoid site, kills cells resistant to paclitaxel and epothilones, and may not require its epoxide moiety for activity.. 41. 2002
Mutational analysis of endonuclease V from Thermotoga maritima.. 41. 2002
Molecular cloning and developmental expression of the caveolin gene family in the amphibian Xenopus laevis.. 41. 2002
Ivermectin and nodulisporic acid receptors in Drosophila melanogaster contain both gamma-aminobutyric acid-gated Rdl and glutamate-gated GluCl alpha chloride channel subunits.. 41. 2002
Transbilayer movement of fluorescent phospholipid analogues in the cytoplasmic membrane of Escherichia coli.. 41. 2002
Structural mechanism of enoyl-CoA hydratase: three atoms from a single water are added in either an E1cb stepwise or concerted fashion.. 41. 2002
Active site analysis of the potential antimicrobial target aspartate semialdehyde dehydrogenase.. 40. 2001
Functional role of a conserved motif in TM6 of the rat mu opioid receptor: constitutively active and inactive receptors result from substitutions of Thr6.34(279) with Lys and Asp.. 40. 2001
Optimization of a versatile in vitro transcription assay for the expression of multiple start site TATA-less promoters.. 40. 2001
Constitutive activation of the mu opioid receptor by mutation of D3.49(164), but not D3.32(147): D3.49(164) is critical for stabilization of the inactive form of the receptor and for its expression.. 40. 2001
Adenovirus-mediated expression of caveolin-1 in mouse liver increases plasma high-density lipoprotein levels.. 40. 2001
Solution structure of a guanine-N7-linked complex of the mitomycin C metabolite 2,7-diaminomitosene and DNA. Basis of sequence selectivity.. 40. 2001
Multiple cleavage activities of endonuclease V from Thermotoga maritima: recognition and strand nicking mechanism.. 40. 2001
Comparison of the amino acid residues in the sixth transmembrane domains accessible in the binding-site crevices of mu, delta, and kappa opioid receptors.. 40. 2001
Inhibition of the aminopeptidase from Aeromonas proteolytica by L-leucinephosphonic acid. Spectroscopic and crystallographic characterization of the transition state of peptide hydrolysis.. 40. 2001
NMR structural and dynamic characterization of the acid-unfolded state of apomyoglobin provides insights into the early events in protein folding.. 40. 2001
Identification of a stability determinant on the edge of the Tet repressor four-helix bundle dimerization motif.. 40. 2001
A RecA homologue in Ustilago maydis that is distinct and evolutionarily distant from Rad51 actively promotes DNA pairing reactions in the absence of auxiliary factors.. 40. 2001
Molecular determinants for Csk-catalyzed tyrosine phosphorylation of the Src tail.. 40. 2001
Peptide backbone chemistry and membrane channel function: effects of a single amide-to-ester replacement on gramicidin channel structure and function.. 40. 2001
Methanococcus jannaschii prolyl-cysteinyl-tRNA synthetase possesses overlapping amino acid binding sites.. 40. 2001
Structural probing of a microdomain in the dopamine transporter by engineering of artificial Zn2+ binding sites.. 39. 2000
High-level expression and mutagenesis of recombinant human phosphatidylcholine transfer protein using a synthetic gene: evidence for a C-terminal membrane binding domain.. 39. 2000
Binding and melting of D-loops by the Bloom syndrome helicase.. 39. 2000
The fourth transmembrane segment of the dopamine D2 receptor: accessibility in the binding-site crevice and position in the transmembrane bundle.. 39. 2000
Recruitment and activation of Raf-1 kinase by nitric oxide-activated Ras.. 39. 2000
Multiple interactions of the Asp(2.61(98)) side chain of the gonadotropin-releasing hormone receptor contribute differentially to ligand interaction.. 39. 2000
Evidence that DNA polymerase delta isolated by immunoaffinity chromatography exhibits high-molecular weight characteristics and is associated with the KIAA0039 protein and RPA.. 39. 2000
Nodulisporic acid opens insect glutamate-gated chloride channels: identification of a new high affinity modulator.. 39. 2000
Crystal structure at 2.4 A resolution of Borrelia burgdorferi inosine 5'-monophosphate dehydrogenase: evidence of a substrate-induced hinged-lid motion by loop 6.. 39. 2000
Native and non-native secondary structure and dynamics in the pH 4 intermediate of apomyoglobin.. 39. 2000
Neighboring aliphatic/aromatic side chain interactions between residues 9 and 10 in gramicidin channels.. 39. 2000
Crystal structure of rabbit phosphoglucose isomerase, a glycolytic enzyme that moonlights as neuroleukin, autocrine motility factor, and differentiation mediator.. 39. 2000
Buried polar interactions and conformational stability in the simian immunodeficiency virus (SIV) gp41 core.. 39. 2000
Quaternary structure of the HSC70 cochaperone HIP.. 39. 2000
Transient dimer in the refolding kinetics of cytochrome c characterized by small-angle X-ray scattering.. 38. 1999
DNA hydrolytic activity associated with the Ustilago maydis REC1 gene product analyzed on hairpin oligonucleotide substrates.. 38. 1999
Regulation of neurabin I interaction with protein phosphatase 1 by phosphorylation.. 38. 1999
Regulation of prostaglandin H2 synthase activity by nitrogen oxides.. 38. 1999
Domain interactions in protein tyrosine kinase Csk.. 38. 1999
1-Butaneboronic acid binding to Aeromonas proteolytica aminopeptidase: a case of arrested development.. 38. 1999
The role of water in the catalytic efficiency of triosephosphate isomerase.. 38. 1999
Structure of a Michaelis complex analogue: propionate binds in the substrate carboxylate site of alanine racemase.. 38. 1999
Modulation of gramicidin channel structure and function by the aliphatic "spacer" residues 10, 12, and 14 between the tryptophans.. 38. 1999
Selective peptide antagonist of the class E calcium channel from the venom of the tarantula Hysterocrates gigas.. 37. 1998
Laser light scattering evidence for a common wormlike growth structure of mixed micelles in bile salt- and straight-chain detergent-phosphatidylcholine aqueous systems: relevance to the micellar structure of bile.. 37. 1998
Trifluoroethanol promotes helix formation by destabilizing backbone exposure: desolvation rather than native hydrogen bonding defines the kinetic pathway of dimeric coiled coil folding.. 37. 1998
The crystal structure of benzoylformate decarboxylase at 1.6 A resolution: diversity of catalytic residues in thiamin diphosphate-dependent enzymes.. 37. 1998
rRNA chemical groups required for aminoglycoside binding.. 37. 1998
Agonist-dependent phosphorylation of the parathyroid hormone/parathyroid hormone-related peptide receptor.. 37. 1998
Mechanism of inducible nitric oxide synthase inactivation by aminoguanidine and L-N6-(1-iminoethyl)lysine.. 37. 1998
Substrate inhibition of D-amino acid transaminase and protection by salts and by reduced nicotinamide adenine dinucleotide: isolation and initial characterization of a pyridoxo intermediate related to inactivation.. 37. 1998
A cluster of aromatic residues in the sixth membrane-spanning segment of the dopamine D2 receptor is accessible in the binding-site crevice.. 37. 1998
Peptide and protein phosphorylation by protein tyrosine kinase Csk: insights into specificity and mechanism.. 37. 1998
The alrestatin double-decker: binding of two inhibitor molecules to human aldose reductase reveals a new specificity determinant.. 36. 1997
Elongation properties of vaccinia virus RNA polymerase: pausing, slippage, 3' end addition, and termination site choice.. 36. 1997
G-protein-mediated signaling in cholesterol-enriched arterial smooth muscle cells. 1. Reduced membrane-associated G-protein content due to diminished isoprenylation of G-gamma subunits and p21ras.. 36. 1997
G-protein-mediated signaling in cholesterol-enriched arterial smooth muscle cells. 2. Role of protein kinase C-delta in the regulation of eicosanoid production.. 36. 1997
Inhibition of Lyn function in mast cell activation by SH3 domain binding peptides.. 36. 1997
Lipid bilayer electrostatic energy, curvature stress, and assembly of gramicidin channels.. 36. 1997
Transbilayer movement of fluorescent phospholipids in Bacillus megaterium membrane vesicles.. 36. 1997
Molecular and macromolecular specificity of human plasma phospholipid transfer protein.. 36. 1997
Determination of the structure of alanine racemase from Bacillus stearothermophilus at 1.9-A resolution.. 36. 1997
Progress curve analysis of the kinetics with which blood coagulation factor XIa is inhibited by protease nexin-2.. 36. 1997
The structural basis for pseudoreversion of the H95N lesion by the secondary S96P mutation in triosephosphate isomerase.. 35. 1996
Na(+)-H+ and Na(+)-Li+ exchange are mediated by the same membrane transport protein in human red blood cells: an NMR investigation.. 35. 1996
Residues in the seventh membrane-spanning segment of the dopamine D2 receptor accessible in the binding-site crevice.. 35. 1996
A binding site expressed on the surface of activated human platelets is shared by factor X and prothrombin.. 35. 1996
Factor X bound to the surface of activated human platelets is preferentially activated by platelet-bound factor IXa.. 35. 1996
Mechanism of the reaction catalyzed by mandelate racemase: structure and mechanistic properties of the D270N mutant.. 35. 1996
Membrane stiffness and channel function.. 35. 1996
Interaction of pyridoxal 5'-phosphate with tryptophan-139 at the subunit interface of dimeric D-amino acid transaminase.. 35. 1996
Membrane organization at low cholesterol concentrations: a study using 7-nitrobenz-2-oxa-1,3-diazol-4-yl-labeled cholesterol.. 35. 1996
Thermodynamic role of the pro region of the neurophysin precursor in neurophysin folding: evidence from the effects of ligand peptides on folding.. 35. 1996
Gramicidin channel function does not depend on phospholipid chirality.. 34. 1995
Unlike the quaternary structure transition, the tertiary structure change of the 240s loop in allosteric aspartate transcarbamylase requires active site saturation by substrate for completion.. 34. 1995
Self-association of the molecular chaperone HSC70.. 34. 1995
The structural basis for pseudoreversion of the E165D lesion by the secondary S96P mutation in triosephosphate isomerase depends on the positions of active site water molecules.. 34. 1995
Luminal calcium regulates the inositol trisphosphate receptor of rat basophilic leukemia cells at a cytosolic site.. 34. 1995
Effect and cellular site of action of cysteine protease inhibitors on the cholesterol esterification pathway in macrophages and Chinese hamster ovary cells.. 34. 1995
Crystal structure of a D-amino acid aminotransferase: how the protein controls stereoselectivity.. 34. 1995
Functional role of arginine-11 in the N-terminal helix of skeletal troponin C: combined mutagenesis and molecular dynamics investigation.. 34. 1995
Stabilizing effect of D-alanine2 in gramicidin channels.. 34. 1995
Design, synthesis, and characterization of a potent xylose isomerase inhibitor, D-threonohydroxamic acid, and high-resolution X-ray crystallographic structure of the enzyme-inhibitor complex.. 34. 1995
Structural analysis of the active site of porcine pancreatic elastase based on the X-ray crystal structures of complexes with trifluoroacetyl-dipeptide-anilide inhibitors.. 34. 1995
Mechanism of the reaction catalyzed by mandelate racemase: importance of electrophilic catalysis by glutamic acid 317.. 34. 1995
Mechanism of the reaction catalyzed by mandelate racemase: structure and mechanistic properties of the K166R mutant.. 34. 1995
NMR behavior of the aromatic protons of bovine neurophysin-I and its peptide complexes: implications for solution structure and for function.. 34. 1995
Stringent and relaxed specificities of TaqI endonuclease: interactions with metal cofactors and DNA sequences.. 34. 1995
Structure of human apolipoprotein D: locations of the intermolecular and intramolecular disulfide links.. 33. 1994
In vitro evidence that phospholipid secretion into bile may be coordinated intracellularly by the combined actions of bile salts and the specific phosphatidylcholine transfer protein of liver.. 33. 1994
Direct structural observation of an acyl-enzyme intermediate in the hydrolysis of an ester substrate by elastase.. 33. 1994
Mutagenic analysis of a receptor contact site on interleukin-2: preparation of an IL-2 analog with increased potency.. 33. 1994
Expression and ligand binding characterization of the beta-subunit (p75) ectodomain of the interleukin-2 receptor.. 33. 1994
X-ray crystallographic structures of D-xylose isomerase-substrate complexes position the substrate and provide evidence for metal movement during catalysis.. 33. 1994
Motionally restricted tryptophan environments at the peptide-lipid interface of gramicidin channels.. 33. 1994
Crystal structure of recombinant chicken triosephosphate isomerase-phosphoglycolohydroxamate complex at 1.8-A resolution.. 33. 1994
Crystal structure of the K12M/G15A triosephosphate isomerase double mutant and electrostatic analysis of the active site.. 33. 1994
Crystal structure of the mutant yeast triosephosphate isomerase in which the catalytic base glutamic acid 165 is changed to aspartic acid.. 33. 1994
An anion binding site in human aldose reductase: mechanistic implications for the binding of citrate, cacodylate, and glucose 6-phosphate.. 33. 1994
Tyrosine-48 is the proton donor and histidine-110 directs substrate stereochemical selectivity in the reduction reaction of human aldose reductase: enzyme kinetics and crystal structure of the Y48H mutant enzyme.. 33. 1994
Isotopic exchange plus substrate and inhibition kinetics of D-xylose isomerase do not support a proton-transfer mechanism.. 33. 1994
Role of the divalent metal ion in sugar binding, ring opening, and isomerization by D-xylose isomerase: replacement of a catalytic metal by an amino acid.. 33. 1994
Intracellular signaling activity of synthetic (14R)-, (14S)-, and (14RS)-14-hydroxy-4,14-retro-retinol.. 33. 1994
The role of lysine 166 in the mechanism of mandelate racemase from Pseudomonas putida: mechanistic and crystallographic evidence for stereospecific alkylation by (R)-alpha-phenylglycidate.. 33. 1994
Eicosanoid metabolism in cholesterol-enriched arterial smooth muscle cells. Evidence for reduced posttranscriptional processing of cyclooxygenase I and reduced cyclooxygenase II gene expression.. 32. 1993
Structure of the Mg(2+)-bound form of CheY and mechanism of phosphoryl transfer in bacterial chemotaxis.. 32. 1993
A novel structural basis for membrane association of a protein: construction of a chimeric soluble mutant of (S)-mandelate dehydrogenase from Pseudomonas putida.. 32. 1993
Activation of the early growth response 1 gene and nuclear pp90rsk in human myeloid leukemia cells by 1-(beta-D-arabinofuranosyl)cytosine.. 32. 1993
Effects of site-directed mutagenesis on the N-glycosylation sites of human lecithin:cholesterol acyltransferase.. 32. 1993
Fluorophore environments in membrane-bound probes: a red edge excitation shift study.. 32. 1993
Roles of cysteines in human lecithin:cholesterol acyltransferase.. 32. 1993
Use of intracellular Ca2+ stores from rat basophilic leukemia cells to study the molecular mechanism leading to quantal Ca2+ release by inositol 1,4,5-trisphosphate.. 32. 1993
The tryptophan residues of aspartate transcarbamylase: site-directed mutagenesis and time-resolved fluorescence spectroscopy.. 31. 1992
Influence of acylation on the channel characteristics of gramicidin A.. 31. 1992
Molecular and channel-forming characteristics of gramicidin K's: a family of naturally occurring acylated gramicidins.. 31. 1992
Gramicidin channels that have no tryptophan residues.. 31. 1992
Effects of temperature on protein structure and dynamics: X-ray crystallographic studies of the protein ribonuclease-A at nine different temperatures from 98 to 320 K.. 31. 1992
Structural basis for the low affinities of yeast cAMP-dependent and mammalian cGMP-dependent protein kinases for protein kinase inhibitor peptides.. 31. 1992
Apolipoprotein E: phospholipid binding studies with synthetic peptides from the carboxyl terminus.. 31. 1992
Effects of high pressure on the catalytic and regulatory properties of UDP-glucuronosyltransferase in intact microsomes.. 31. 1992
Regulated expression of sterol carrier protein 2 in the ovary: a key role for cyclic AMP.. 30. 1991
Mechanism of the reaction catalyzed by mandelate racemase. 2. Crystal structure of mandelate racemase at 2.5-A resolution: identification of the active site and possible catalytic residues.. 30. 1991
Amino acid sequence modulation of gramicidin channel function: effects of tryptophan-to-phenylalanine substitutions on the single-channel conductance and duration.. 30. 1991
Computer simulation and analysis of the reaction pathway of triosephosphate isomerase.. 30. 1991
Structure of the triosephosphate isomerase-phosphoglycolohydroxamate complex: an analogue of the intermediate on the reaction pathway.. 30. 1991
Spontaneous phospholipid transfer: development of a quantitative model.. 30. 1991
Three-dimensional structure of murine anti-p-azophenylarsonate Fab 36-71. 1. X-ray crystallography, site-directed mutagenesis, and modeling of the complex with hapten.. 30. 1991
Three-dimensional structure of murine anti-p-azophenylarsonate Fab 36-71. 2. Structural basis of hapten binding and idiotypy.. 30. 1991
Electrophilic catalysis in triosephosphate isomerase: the role of histidine-95.. 30. 1991
Activity and structure of the active-site mutants R386Y and R386F of Escherichia coli aspartate aminotransferase.. 30. 1991
The 2.1-A resolution structure of iron superoxide dismutase from Pseudomonas ovalis.. 29. 1990
65-kilodalton protein phosphorylated by interleukin 2 stimulation bears two putative actin-binding sites and two calcium-binding sites.. 29. 1990
The catalytic site of Escherichia coli aspartate transcarbamylase: interaction between histidine 134 and the carbonyl group of the substrate carbamyl phosphate.. 29. 1990
Photolysis and deacylation of inhibited chymotrypsin.. 29. 1990
Crystallographic analysis of the complex between triosephosphate isomerase and 2-phosphoglycolate at 2.5-A resolution: implications for catalysis.. 29. 1990
Structure of yeast triosephosphate isomerase at 1.9-A resolution.. 29. 1990
Organization of microsomal UDP-glucuronosyltransferase. Activation by treatment at high pressure.. 29. 1990
Structure and activity of two photoreversible cinnamates bound to chymotrypsin.. 29. 1990
High-density-lipoprotein-induced cholesterol efflux from arterial smooth muscle cell derived foam cells: functional relationship of the cholesteryl ester cycle and eicosanoid biosynthesis.. 29. 1990
Characterization of interleukin 2 stimulated 65-kilodalton phosphoprotein in human T cells.. 29. 1990
Distinction between dipolar and inductive effects in modulating the conductance of gramicidin channels.. 29. 1990
Kinetics of calcium channel opening by inositol 1,4,5-trisphosphate.. 29. 1990
Effects of D-serine on bacterial D-amino acid transaminase: accumulation of an intermediate and inactivation of the enzyme.. 28. 1989
Platelet-neutrophil-smooth muscle cell interactions: lipoxygenase-derived mono- and dihydroxy acids activate cholesteryl ester hydrolysis by the cyclic AMP dependent protein kinase cascade.. 28. 1989
Crystallographic studies of the mechanism of xylose isomerase.. 28. 1989
Induction of conductance heterogeneity in gramicidin channels.. 28. 1989
Lysophosphatidylcholine metabolism to 1,2-diacylglycerol in lymphoblasts: involvement of a phosphatidylcholine-hydrolyzing phospholipase C.. 28. 1989
Activity and spectroscopic properties of bacterial D-amino acid transaminase after multiple site-directed mutagenesis of a single tryptophan residue.. 28. 1989
Site-directed mutagenesis of the cysteinyl residues and the active-site serine residue of bacterial D-amino acid transaminase.. 28. 1989
Kinetics and mechanism of transfer of synthetic model apolipoproteins.. 27. 1988
A structure of sperm whale myoglobin at a nitrogen gas pressure of 145 atmospheres.. 27. 1988
Triosephosphate isomerase: removal of a putatively electrophilic histidine residue results in a subtle change in catalytic mechanism.. 27. 1988
Structure of a ganglioside with Cad blood group antigen activity.. 27. 1988
Apolipoproteins C-I, C-II, and C-III: kinetics of association with model membranes and intermembrane transfer.. 27. 1988
Cytochrome P-450C-M/F, a new constitutive form of microsomal cytochrome P-450 in male and female rat liver with estrogen 2- and 16 alpha-hydroxylase activity.. 27. 1988
A possible model for the concerted allosteric transition in Escherichia coli aspartate transcarbamylase as deduced from site-directed mutagenesis studies.. 27. 1988
Relationship between domain closure and binding, catalysis, and regulation in Escherichia coli aspartate transcarbamylase.. 27. 1988
Ribonuclease structure and catalysis: crystal structure of sulfate-free native ribonuclease A at 1.5-A resolution.. 26. 1987
Monoclonal antibodies as probes of high-density lipoprotein structure: identification and localization of a lipid-dependent epitope.. 26. 1987
Characterization of the M1(Ala213) type of alpha 1-antitrypsin, a newly recognized, common "normal" alpha 1-antitrypsin haplotype.. 26. 1987
Tac antigen forms disulfide-linked homodimers.. 26. 1987
Subunit interface of triosephosphate isomerase: site-directed mutagenesis and characterization of the altered enzyme.. 26. 1987
Thermal expansion of a protein.. 26. 1987
Fluorescence quenching studies of apolipoprotein A-I in solution and in lipid-protein complexes: protein dynamics.. 25. 1986
Ether phosphatidylcholines: comparison of miscibility with ester phosphatidylcholines and sphingomyelin, vesicle fusion, and association with apolipoprotein A-I.. 25. 1986
Topoisomerase from Ustilago maydis forms a covalent complex with single-stranded DNA through a phosphodiester bond to tyrosine.. 25. 1986
Evidence for a single steroid-binding protein in the rabbit progesterone receptor.. 25. 1986
Investigation of the interaction between thallous ions and gramicidin A in dimyristoylphosphatidylcholine vesicles: a thallium-205 NMR equilibrium study.. 25. 1986
Human type III collagen gene expression is coordinately modulated with the type I collagen genes during fibroblast growth.. 25. 1986
Lateral distribution of phospholipid and cholesterol in apolipoprotein A-I recombinants.. 24. 1985
Apolipoprotein E: phospholipid binding studies with synthetic peptides containing the putative receptor binding region.. 24. 1985
Interfacial properties of model membranes and plasma lipoproteins containing ether lipids.. 24. 1985
Functional and immunochemical characterization of a mutant of Escherichia coli energy uncoupled for lactose transport.. 24. 1985
Pyrenedodecanoylcarnitine and pyrenedodecanoyl coenzyme A: kinetics and thermodynamics of their intermembrane transfer.. 23. 1984
In vitro binding of synthetic acylated lipid-associating peptides to high-density lipoproteins: effect of hydrophobicity.. 23. 1984
Thermotropic properties and molecular dynamics of cholesteryl ester rich very low density lipoproteins: effect of hydrophobic core on polar surface.. 23. 1984
Monoclonal antibodies against the lac carrier protein from Escherichia coli. 1. Functional studies.. 23. 1984
Monoclonal antibodies against the lac carrier protein from Escherichia coli. 2. Binding studies with membrane vesicles and proteoliposomes reconstituted with purified lac carrier protein.. 23. 1984
Cavities in proteins: structure of a metmyoglobin-xenon complex solved to 1.9 A.. 23. 1984
Lysosomal function in the degradation of defective collagen in cultured lung fibroblasts.. 23. 1984
Reaction of myoglobin with phenylhydrazine: a molecular doorstop.. 23. 1984
Action of lipoprotein lipase on phospholipid monolayers. Activation by apolipoprotein C-II.. 22. 1983
Studies of calmodulin structure: laser raman spectroscopy of biomolecules.. 22. 1983
Interaction of several class II and III RNA polymerases with two families of 7'-substituted alpha-amanitin.. 21. 1982
Kinetics and mechanism of the spontaneous transfer of fluorescent phosphatidylcholines between apolipoprotein-phospholipid recombinants.. 21. 1982
(I-pyrenebutyryl)carnitine and 1-pyrenebutyryl coenzyme A: fluorescent probes for lipid metabolite studies in artificial and natural membranes.. 21. 1982
5-(dimethylamino)naphthalene-1-sulfonic acid, a fluorescent probe of the medium chain fatty acid binding site of serum albumin.. 21. 1982
Kinetics and mechanism of association of human plasma apolipoproteins with dimyristoylphosphatidylcholine: effect of protein structure and lipid clusters on reaction rates.. 20. 1981
Modulation of tropoelastin production and elastin messenger ribonucleic acid activity in developing sheep lung.. 20. 1981
Binding, surface mobility, internalization, and degradation of rhodamine-labeled alpha 2-macroglobulin.. 20. 1981
Mechanism of lipid-protein interaction in the plasma lipoproteins: identification of a lipid-binding site in apolipoprotein A-II.. 20. 1981
Physical properties of lipid-protein complexes formed by the interaction of dimyristoylphosphatidylcholine and human high-density apolipoprotein A-II.. 20. 1981
Thermodynamics of lipid-protein interactions: Interaction of apolipoprotein A-II from human plasma high-density lipoproteins with dimyristoylphosphatidylcholine.. 20. 1981
Raman spectroscopy of the thermal properties of reassembled high-density lipoprotein: apolipoprotein A-I complexes of dimyristoylphosphatidylcholine.. 20. 1981
Magnetic resonance studies of apolipoprotein C-I nitroxide labeled or [13C]methyl enriched at methionine-38.. 19. 1980
Lipoprotein-X: carbon-13 nuclear magnetic resonance studies on native, reconstituted, and model systems.. 19. 1980
Lipoprotein-X: proton and phosphorus-31 nuclear magnetic resonance studies on native, reconstituted, and model systems.. 19. 1980
Serum lipoprotein structure: resonance energy transfer localization of fluorescent lipid probes.. 19. 1980
Immunochemistry of human very low density lipoproteins: apolipoprotein C-III.. 19. 1980
Mechanism and kinetics of transfer of a fluorescent fatty acid between single-walled phosphatidylcholine vesicles.. 19. 1980
Mechanism of lipid--protein interaction in the plasma lipoproteins: relationship of lipid-binding sites to antigenic sites in apolipoprotein A-II.. 18. 1979
Apolipoprotein A-II: chemical synthesis and biophysical properties of three peptides corresponding to fragments in the amino-terminal half.. 18. 1979
Improvements in the prediction of protein backbone topography by reduction of statistical errors.. 18. 1979
Kinetics of lipid--protein interactions: effect of cholesterol on the association of human plasma high-density apolipoprotein A-I with L-alpha-dimyristoylphosphatidylcholine.. 18. 1979
Structure of the dimyristoylphosphatidylcholine vesicle and the complex formed by its interaction with apolipoprotein C-III: X-ray small-angle scattering studies.. 18. 1979
N-(2-Naphthyl)-23,24-dinor-5-cholen-22-amin-3beta-ol, a fluorescent cholesterol analogue.. 17. 1978
Chemical and physical characterization of cholinergic synaptic vesicles.. 17. 1978
Kinetics of lipid--protein interactions: interaction of apolipoprotein A-I from human plasma high density lipoproteins with phosphatidylcholines.. 17. 1978
Purification of synaptic vesicles from elasmobranch electric organ and the use of biophysical criteria to demonstrate purity.. 17. 1978
Lipid binding by fragments of apolipoprotein C-III-1 obtained by thrombin cleavage.. 16. 1977
Interaction of plasma "arginine-rich" apolipoprotein with dimyristoylphosphatidylcholine.. 16. 1977
A Raman spectroscopic investigation of the disulfide conformation in oxytocin and lysine vasopressin.. 16. 1977
Mechanism of lipid-protein interaction in the plasma lipoproteins: lipid-binding properties of synthetic fragments of apolipoprotein A-II.. 16. 1977
Amylo-1,6-glucosidase/4-alpha-glucanotransferase: use of reversible substrate model inhibitors to study the binding and active sites of rabbit muscle debranching enzyme.. 16. 1977
Characterization of baboon plasma high-density lipoproteins and of their major apoproteins.. 16. 1977
Physical properties of the dimyristoylphosphatidylcholine vesicle and of complexes formed by its interaction with apolipoprotein C-III.. 16. 1977
Enzymatic oxidation of cobalt protoporphyrin IX: observations on the mechanism of heme oxygenase action.. 16. 1977
Status of empirical methods for the prediction of protein backbone topography.. 15. 1976
Amyloid A: amphipathic helixes and lipid binding.. 15. 1976
Structure of an apolipoprotein-phospholipid complex: apoC-III induced changes in the physical properties of dimyristoylphosphatidylcholine.. 15. 1976
Effect of the human plasma apolipoproteins and phosphatidylcholine acyl donor on the activity of lecithin: cholesterol acyltransferase.. 14. 1975
5-methyl-5,6,7,8-tetrahydropteroyl oligo-gamma-L-glutamates: synthesis and kinetic studies with methionine synthetase from bovine brain.. 14. 1975
Acetylcholine receptor in normal and denervated slow and fast muscle.. 13. 1974
A comparative electron spin resonance study of the erythrocyte membrane in myotonic muscular dystrophy.. 13. 1974
Structure of the major complex formed by interaction of phosphatidylcholine bilamellar vesicles and apolipoprotein-alanine (APO-C-III).. 13. 1974
Phase transitions in bilamellar vesicles. Measurements by pyrene excimer fluorescence and effect on transacylation by lecithin: cholesterol acyltransferase.. 13. 1974
Fluorescence quenching of anthracene in charged micelles by pyridinium and iodide ions.. 13. 1974
Interaction of apolipoprotein-alamine and apolipoprotein-glutamine-I with phosphatidylcholine. Effect on solute quenching of intrinsic fluorescence.. 13. 1974
Isolation and characterization of the cyanogen bromide fragments from the high-density apolipoprotein glutamine I.. 12. 1973
Application of laser self-beat spectroscopic technique to the study of solutions of human plasma low-density lipoproteins.. 12. 1973
Interaction of an apolipoprotein (apoLP-alanine) with phosphatidylcholine.. 12. 1973
Transcription of ribonucleic acid by the ribonucleic acid directed deoxyribonucleic acid polymerase of Rous sarcoma virus and deoxyribonucleic acid polymerase I of Escherichia coli.. 12. 1973
Ribonucleic acid directed deoxyribonucleic acid synthesis by the purified deoxyribonucleic acid polymerase of Rous sarcoma virus. Characterization of the enzymatic product.. 11. 1972
Homonuclear indor spectroscopy as a means of simplifying and analyzing proton magnetic resonance spectra of peptides and as a basis for determining secondary and tertiary conformations of complex peptides.. 11. 1972
Observations on the conformation of human serum high-density lipoproteins using infrared spectroscopy, circular dichroism, and electron spin resonance.. 9. 1970
Human platelet membrane protein.. 9. 1970
Biochemical studies of synapses in vitro. II. Potassium transport.. 8. 1969
Biochemical studies of synapses in vitro. I. Protein synthesis.. 7. 1968
METABOLISM OF D-VALINE BY STREPTOMYCES ANTIBIOTICUS: ISOLATION OF N-SUCCINYL-D-VALINE.. 3. 1964
The mechanism of an osmotic instability induced in E. coli K-12 by 5-fluorouracil.. 1. 1962

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