Intracerebroventricular leptin regulates hepatic cholesterol metabolism. Academic Article uri icon

Overview

abstract

  • To elucidate the control of hepatic cholesterol metabolism by leptin, rats were administered IV (intravenous) leptin, ICV (intracerebroventricular) leptin or saline. A single low dose of ICV leptin was as effective as a continuous IV infusion of high-dose leptin at decreasing the activities of 3-hydroxy-3-methylglutaryl-CoA reductase and cholesterol 7alpha-hydroxylase. These results indicate that the hepatic response to leptin is transduced via the central nervous system.

publication date

  • April 15, 2004

Research

keywords

  • Cholesterol
  • Leptin
  • Liver

Identity

PubMed Central ID

  • PMC1224095

Scopus Document Identifier

  • 2342584091

Digital Object Identifier (DOI)

  • 10.1042/BJ20040134

PubMed ID

  • 14984364

Additional Document Info

volume

  • 379

issue

  • Pt 2