Cell signaling and function organized by PB1 domain interactions. Review uri icon

Overview

abstract

  • The PB1-domain-containing proteins p62, aPKC, MEKK2/MEKK3, MEK5, and Par-6 play roles in critical cell processes like osteoclastogenesis, angiogenesis, and early cardiovascular development or cell polarity. PB1 domains are scaffold modules that adopt the topology of ubiquitin-like beta-grasp folds that interact with each other in a front-to-back mode to arrange heterodimers or homo-oligomers. The different PB1 domain adaptors provide specificity for PB1 kinases to ensure the effective transmission of cellular signals. Also, recent data suggest that PB1 domains may serve to orchestrate signaling cascades not involving other PB1 domains, such as the MEK5-ERK5 and p62-ERK1 interactions.

publication date

  • September 1, 2006

Research

keywords

  • Nuclear Proteins
  • Signal Transduction
  • Transcription Factors

Identity

Scopus Document Identifier

  • 33747886310

Digital Object Identifier (DOI)

  • 10.1016/j.molcel.2006.08.002

PubMed ID

  • 16949360

Additional Document Info

volume

  • 23

issue

  • 5