Molecular cell

publication venue for

A Dominant Mutation in Human RAD51 Reveals Its Function in DNA Interstrand Crosslink Repair Independent of Homologous Recombination. 2015
CDT1 inhibits CMG helicase in early S phase to separate origin licensing from DNA synthesis.. 83. 2023
POLθ prevents MRE11-NBS1-CtIP-dependent fork breakage in the absence of BRCA2/RAD51 by filling lagging-strand gaps.. 82. 2022
A field guide to endogenous retrovirus regulatory networks.. 82. 2022
Error-prone repair of stalled replication forks drives mutagenesis and loss of heterozygosity in haploinsufficient BRCA1 cells.. 82. 2022
DNA damage promotes HLA class I presentation by stimulating a pioneer round of translation-associated antigen production.. 82. 2022
A recurrent chromosomal inversion suffices for driving escape from oncogene-induced senescence via subTAD reorganization.. 81. 2021
PKCλ/ι inhibition activates an ULK2-mediated interferon response to repress tumorigenesis.. 81. 2021
Structural features of nucleosomes in interphase and metaphase chromosomes.. 81. 2021
Lysine acetylation restricts mutant IDH2 activity to optimize transformation in AML cells.. 81. 2021
Targeting histone acetylation dynamics and oncogenic transcription by catalytic P300/CBP inhibition.. 81. 2021
mTORC1 promotes cell growth via m⁶A-dependent mRNA degradation.. 81. 2021
H3K27ac bookmarking promotes rapid post-mitotic activation of the pluripotent stem cell program without impacting 3D chromatin reorganization.. 81. 2021
Unique Immune Cell Coactivators Specify Locus Control Region Function and Cell Stage.. 80. 2020
Zmat3 Is a Key Splicing Regulator in the p53 Tumor Suppression Program.. 80. 2020
Structural Basis of the Activation of Heterotrimeric Gs-Protein by Isoproterenol-Bound β₁-Adrenergic Receptor.. 80. 2020
High-Resolution In Vivo Identification of miRNA Targets by Halo-Enhanced Ago2 Pull-Down.. 79. 2020
MYC Controls the Epstein-Barr Virus Lytic Switch.. 78. 2020
Altered m⁶A Modification of Specific Cellular Transcripts Affects Flaviviridae Infection.. 77. 2019
Transient Hysteresis in CDK4/6 Activity Underlies Passage of the Restriction Point in G1.. 76. 2019
Bicoid-Dependent Activation of the Target Gene hunchback Requires a Two-Motif Sequence Code in a Specific Basal Promoter.. 75. 2019
Identification of the m⁶Am Methyltransferase PCIF1 Reveals the Location and Functions of m⁶Am in the Transcriptome.. 75. 2019
Cyclin F Controls Cell-Cycle Transcriptional Outputs by Directing the Degradation of the Three Activator E2Fs.. 74. 2019
TAF5L and TAF6L Maintain Self-Renewal of Embryonic Stem Cells via the MYC Regulatory Network.. 74. 2019
An NAD⁺ Phosphorylase Toxin Triggers Mycobacterium tuberculosis Cell Death.. 73. 2019
The F-Box Domain-Dependent Activity of EMI1 Regulates PARPi Sensitivity in Triple-Negative Breast Cancers.. 73. 2018
ZFX Mediates Non-canonical Oncogenic Functions of the Androgen Receptor Splice Variant 7 in Castrate-Resistant Prostate Cancer.. 72. 2018
Mycobacterial Mutagenesis and Drug Resistance Are Controlled by Phosphorylation- and Cardiolipin-Mediated Inhibition of the RecA Coprotease.. 72. 2018
Binding of TMPRSS2-ERG to BAF Chromatin Remodeling Complexes Mediates Prostate Oncogenesis.. 71. 2018
MRI Is a DNA Damage Response Adaptor during Classical Non-homologous End Joining.. 71. 2018
MLL4 Is Required to Maintain Broad H3K4me3 Peaks and Super-Enhancers at Tumor Suppressor Genes.. 70. 2018
mTORC1 Promotes Metabolic Reprogramming by the Suppression of GSK3-Dependent Foxk1 Phosphorylation.. 70. 2018
Phosphatidylinositol-5-Phosphate 4-Kinases Regulate Cellular Lipid Metabolism By Facilitating Autophagy.. 70. 2018
The Dietary Supplement Chondroitin-4-Sulfate Exhibits Oncogene-Specific Pro-tumor Effects on BRAF V600E Melanoma Cells.. 69. 2018
The Histone Chaperones ASF1 and CAF-1 Promote MMS22L-TONSL-Mediated Rad51 Loading onto ssDNA during Homologous Recombination in Human Cells.. 69. 2018
Engineering of a Histone-Recognition Domain in Dnmt3a Alters the Epigenetic Landscape and Phenotypic Features of Mouse ESCs.. 69. 2018
Greater Than the Sum of Parts: Complexity of the Dynamic Epigenome.. 69. 2018
The Augmented R-Loop Is a Unifying Mechanism for Myelodysplastic Syndromes Induced by High-Risk Splicing Factor Mutations.. 69. 2018
Focal Adhesion- and IGF1R-Dependent Survival and Migratory Pathways Mediate Tumor Resistance to mTORC1/2 Inhibition.. 67. 2017
Argonaute CLIP Defines a Deregulated miR-122-Bound Transcriptome that Correlates with Patient Survival in Human Liver Cancer.. 67. 2017
Heterogeneous Ribosomes Preferentially Translate Distinct Subpools of mRNAs Genome-wide.. 67. 2017
Celastrol-Induced Nur77 Interaction with TRAF2 Alleviates Inflammation by Promoting Mitochondrial Ubiquitination and Autophagy.. 66. 2017
PARK2 Depletion Connects Energy and Oxidative Stress to PI3K/Akt Activation via PTEN S-Nitrosylation.. 65. 2017
Thinking Outside the Cell: Replicating Replication In Vitro.. 65. 2017
An Autoinhibited Dimeric Form of BAX Regulates the BAX Activation Pathway.. 64. 2016
Chromatin Kinases Act on Transcription Factors and Histone Tails in Regulation of Inducible Transcription.. 64. 2016
FANCD2 Facilitates Replication through Common Fragile Sites.. 64. 2016
OCT4 Acts as an Integrator of Pluripotency and Signal-Induced Differentiation.. 63. 2016
A Highly Sensitive and Robust Method for Genome-wide 5hmC Profiling of Rare Cell Populations.. 63. 2016
An Autoinhibited Dimeric Form of BAX Regulates the BAX Activation Pathway.. 63. 2016
TRIM21 Ubiquitylates SQSTM1/p62 and Suppresses Protein Sequestration to Regulate Redox Homeostasis.. 61. 2016
A Multiplexed System for Quantitative Comparisons of Chromatin Landscapes.. 61. 2015
Functional Dynamics within the Human Ribosome Regulate the Rate of Active Protein Synthesis.. 60. 2015
Endogenous Formaldehyde Is a Hematopoietic Stem Cell Genotoxin and Metabolic Carcinogen.. 60. 2015
An Interactive Database for the Assessment of Histone Antibody Specificity.. 59. 2015
ERK2 Mediates Metabolic Stress Response to Regulate Cell Fate.. 59. 2015
Metabolic Rewiring by Oncogenic BRAF V600E Links Ketogenesis Pathway to BRAF-MEK1 Signaling.. 59. 2015
Engineering of a Histone-Recognition Domain in Dnmt3a Alters the Epigenetic Landscape and Phenotypic Features of Mouse ESCs.. 59. 2015
Distinct tRNA Accommodation Intermediates Observed on the Ribosome with the Antibiotics Hygromycin A and A201A.. 58. 2015
ATP-dependent effector-like functions of RIG-I-like receptors.. 58. 2015
Ubiquitin-dependent lysosomal membrane protein sorting and degradation.. 57. 2015
Asparagine plays a critical role in regulating cellular adaptation to glutamine depletion.. 56. 2014
O-GlcNAcylation regulates cancer metabolism and survival stress signaling via regulation of the HIF-1 pathway.. 54. 2014
Distinct and combinatorial functions of Jmjd2b/Kdm4b and Jmjd2c/Kdm4c in mouse embryonic stem cell identity.. 53. 2013
The DNA replication program is altered at the FMR1 locus in fragile X embryonic stem cells.. 53. 2013
Autoinhibition and Polo-dependent multisite phosphorylation restrict activity of the histone H3 kinase Haspin to mitosis.. 52. 2013
Dosage of Dyrk1a shifts cells within a p21-cyclin D1 signaling map to control the decision to enter the cell cycle.. 52. 2013
Structural architecture of the CARMA1/Bcl10/MALT1 signalosome: nucleation-induced filamentous assembly.. 51. 2013
K63 polyubiquitination and activation of mTOR by the p62-TRAF6 complex in nutrient-activated cells.. 51. 2013
Akt-mediated phosphorylation of argonaute 2 downregulates cleavage and upregulates translational repression of MicroRNA targets.. 50. 2013
AMPK-dependent degradation of TXNIP upon energy stress leads to enhanced glucose uptake via GLUT1.. 49. 2013
PGC-1 coactivators regulate MITF and the tanning response.. 49. 2012
Metabolic stress controls mTORC1 lysosomal localization and dimerization by regulating the TTT-RUVBL1/2 complex.. 49. 2012
Transcriptome-wide miR-155 binding map reveals widespread noncanonical microRNA targeting.. 48. 2012
Cytoplasmic STAT3 represses autophagy by inhibiting PKR activity.. 48. 2012
Cooperative activation of PI3K by Ras and Rho family small GTPases.. 47. 2012
A two-dimensional ERK-AKT signaling code for an NGF-triggered cell-fate decision.. 45. 2011
Chemical genetic screen for AMPKα2 substrates uncovers a network of proteins involved in mitosis.. 44. 2011
Aurora-B mediated ATM serine 1403 phosphorylation is required for mitotic ATM activation and the spindle checkpoint.. 44. 2011
Structure and dynamics of the mammalian ribosomal pretranslocation complex.. 44. 2011
The three-dimensional architecture of a bacterial genome and its alteration by genetic perturbation.. 44. 2011
p62 is a key regulator of nutrient sensing in the mTORC1 pathway.. 44. 2011
Directional DNA methylation changes and complex intermediate states accompany lineage specificity in the adult hematopoietic compartment.. 44. 2011
Deciphering the RNA polymerase II CTD code in fission yeast.. 43. 2011
A SIRT1-LSD1 corepressor complex regulates Notch target gene expression and development.. 42. 2011
ERK-MAPK drives lamellipodia protrusion by activating the WAVE2 regulatory complex.. 41. 2011
Elevated histone expression promotes life span extension.. 39. 2010
Sin1-mTORC2 suppresses rag and il7r gene expression through Akt2 in B cells.. 39. 2010
Glucose addiction of TSC null cells is caused by failed mTORC1-dependent balancing of metabolic demand with supply.. 38. 2010
ERK2 but not ERK1 induces epithelial-to-mesenchymal transformation via DEF motif-dependent signaling events.. 38. 2010
Endoplasmic reticulum stress induces G2 cell-cycle arrest via mRNA translation of the p53 isoform p53/47.. 38. 2010
Revealing global regulatory perturbations across human cancers.. 36. 2009
Brh2 promotes a template-switching reaction enabling recombinational bypass of lesions during DNA synthesis.. 36. 2009
Stepwise activation of BAX and BAK by tBID, BIM, and PUMA initiates mitochondrial apoptosis.. 36. 2009
Targeting HSP70 for cancer therapy.. 36. 2009
A genome-wide siRNA screen reveals diverse cellular processes and pathways that mediate genome stability.. 35. 2009
CUL4A abrogation augments DNA damage response and protection against skin carcinogenesis.. 34. 2009
TFIIH and P-TEFb coordinate transcription with capping enzyme recruitment at specific genes in fission yeast.. 33. 2009
Second-end capture in DNA double-strand break repair promoted by Brh2 protein of Ustilago maydis.. 33. 2009
Structural basis for recognition of diubiquitins by NEMO.. 33. 2009
Resolving resolvases: the final act?. 32. 2008
An unusual allosteric mobility of the C-terminal helix of a high-affinity alphaL integrin I domain variant bound to ICAM-5.. 31. 2008
RNA repair: an antidote to cytotoxic eukaryal RNA damage.. 31. 2008
A conformational rearrangement in the spliceosome sets the stage for Prp22-dependent mRNA release.. 30. 2008
The mechanism of a neurotransmitter:sodium symporter--inward release of Na+ and substrate is triggered by substrate in a second binding site.. 30. 2008
Regulation of cell signaling dynamics by the protein kinase-scaffold Ste5.. 30. 2008
Comprehensive identification of PIP3-regulated PH domains from C. elegans to H. sapiens by model prediction and live imaging.. 30. 2008
Ran-binding protein 3 phosphorylation links the Ras and PI3-kinase pathways to nucleocytoplasmic transport.. 29. 2008
Structure of a BCOR corepressor peptide in complex with the BCL6 BTB domain dimer.. 29. 2008
Nonapoptotic role for Apaf-1 in the DNA damage checkpoint.. 28. 2007
A hypoxia-controlled cap-dependent to cap-independent translation switch in breast cancer.. 28. 2007
A universal framework for regulatory element discovery across all genomes and data types.. 28. 2007
Functional interdependence at the chromatin level between the MKK6/p38 and IGF1/PI3K/AKT pathways during muscle differentiation.. 28. 2007
Identification of two distinct hybrid state intermediates on the ribosome.. 25. 2007
An acetylation site in the middle domain of Hsp90 regulates chaperone function.. 25. 2007
A stapled BID BH3 helix directly binds and activates BAX.. 24. 2006
A kinase-independent function of c-Abl in promoting proteolytic destruction of damaged DNA binding proteins.. 22. 2006
c-Myc phosphorylation is required for cellular response to oxidative stress.. 21. 2006
Transcriptional activators are dispensable for transcription in the absence of Spt6-mediated chromatin reassembly of promoter regions.. 21. 2006
Detection of high-affinity and sliding clamp modes for MSH2-MSH6 by single-molecule unzipping force analysis.. 20. 2005
MDM2 promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma protein.. 20. 2005
Heterochromatin focuses on senescence.. 17. 2005
Crystal structure of IIGP1: a paradigm for interferon-inducible p47 resistance GTPases.. 15. 2004
Molecular mechanism of transcription inhibition by peptide antibiotic Microcin J25.. 14. 2004
Chromatin disassembly mediated by the histone chaperone Asf1 is essential for transcriptional activation of the yeast PHO5 and PHO8 genes.. 14. 2004
Genome-wide analysis of membrane targeting by S. cerevisiae pleckstrin homology domains.. 13. 2004
A function of yeast mRNA cap methyltransferase, Abd1, in transcription by RNA polymerase II.. 13. 2004
Mechanism of SMRT corepressor recruitment by the BCL6 BTB domain.. 12. 2003
Hedgehog signal transduction via Smoothened association with a cytoplasmic complex scaffolded by the atypical kinesin, Costal-2.. 12. 2003
The BRCA2-interacting protein DSS1 is vital for DNA repair, recombination, and genome stability in Ustilago maydis.. 12. 2003
BRCA2 homolog required for proficiency in DNA repair, recombination, and genome stability in Ustilago maydis.. 10. 2002
Tat stimulates cotranscriptional capping of HIV mRNA.. 10. 2002
Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway.. 10. 2002
Targeted disruption of the zetaPKC gene results in the impairment of the NF-kappaB pathway.. 8. 2001
Akt-mediated phosphorylation of the G protein-coupled receptor EDG-1 is required for endothelial cell chemotaxis.. 8. 2001
BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis.. 8. 2001
Analysis of telomerase processivity: mechanistic similarity to HIV-1 reverse transcriptase and role in telomere maintenance.. 7. 2001
Mutations in the P. falciparum digestive vacuole transmembrane protein PfCRT and evidence for their role in chloroquine resistance.. 6. 2000
Class C Vps protein complex regulates vacuolar SNARE pairing and is required for vesicle docking/fusion.. 6. 2000
Harnessing the ubiquitination machinery to target the degradation of specific cellular proteins.. 6. 2000
The hPLIC proteins may provide a link between the ubiquitination machinery and the proteasome.. 6. 2000
Aven, a novel inhibitor of caspase activation, binds Bcl-xL and Apaf-1.. 6. 2000
Acquisition of oncogenic potential by RAR chimeras in acute promyelocytic leukemia through formation of homodimers.. 5. 2000
A novel mycolic acid cyclopropane synthetase is required for cording, persistence, and virulence of Mycobacterium tuberculosis.. 5. 2000
Regulation of Wnt signaling by Sox proteins: XSox17 alpha/beta and XSox3 physically interact with beta-catenin.. 4. 1999
Phosphatidylinositol 3-phosphate recognition by the FYVE domain.. 3. 1999
Arrangement of subunits in 20 S particles consisting of NSF, SNAPs, and SNARE complexes.. 2. 1998
Ubiquitination and degradation of the substrate recognition subunits of SCF ubiquitin-protein ligases.. 2. 1998
Ku70: a candidate tumor suppressor gene for murine T cell lymphoma.. 2. 1998
Phosphatidylinositol(3)-phosphate signaling mediated by specific binding to RING FYVE domains.. 2. 1998
Alkyl hydroperoxide reductase subunit C (AhpC) protects bacterial and human cells against reactive nitrogen intermediates.. 1. 1998
Terminal differentiation of human breast cancer through PPAR gamma.. 1. 1998
The Histone Chaperones ASF1 and CAF-1 Promote MMS22L-TONSL-Mediated Rad51 Loading onto ssDNA during Homologous Recombination in Human Cells.. 77. 2020
TRIM21 Ubiquitylates SQSTM1/p62 and Suppresses Protein Sequestration to Regulate Redox Homeostasis.. 62. 2016
The BAFfling story of MN1-induced leukemogenesis. 2021
TARGET-seq Takes Aim at Cancer Evolution through Multi-omics Single-Cell Genotyping and Transcriptomics. 2019
A Much-Needed Boost for the Dwindling Antibiotic Pipeline. 2018
Defective Autophagy Initiates Malignant Transformation. 2016
Akt-ivation of RNA splicing. 2014
A web of interactions at the ends. 2011
ATM: Promoter of metabolic "cost" reduction and "savings" usage during hypoxia through mTORC1 regulation. 2010
SETting the clock for histone H4 monomethylation. 2010
Closing the feedback loop: how cells "count" telomere-bound proteins. 2009
Deadly splicing: Bax becomes Almighty. 2009
Linking differential chromatin loops to transcriptional decisions. 2008
PHLPPing it off: phosphatases get in the Akt. 2007
Editorial Note to: Glucose Addiction of TSC Null Cells Is Caused by Failed mTORC1-Dependent Balancing of Metabolic Demand with Supply.. 81. 2021
Hidden codes in mRNA: Control of gene expression by m⁶A. 2022
Ca²⁺ Fluxes and Cancer. 2020
DNA Damage in Stem Cells. 2017
Greater Than the Sum of Parts: Complexity of the Dynamic Epigenome. 2016
Drugging Chromatin in Cancer: Recent Advances and Novel Approaches. 2015
Organelle-Specific Initiation of Autophagy. 2015
Preparing the first responders: building the inflammatory transcriptome from the ground up. 2014
DCAFs, the missing link of the CUL4-DDB1 ubiquitin ligase. 2007
Cell signaling and function organized by PB1 domain interactions. 2006
RNAi targeting an animal virus: news from the front. 2002

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Molecular cell Journal

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