PHLPPing it off: phosphatases get in the Akt. uri icon

Overview

abstract

  • Three Akt isoforms differentially control cell survival, growth, proliferation, metabolism, and motility. In this issue of Molecular Cell, Brognard et al. (2007) report that two PHLPP phosphatases specifically downregulate the Akts to control the activity of isoform-specific substrates.

publication date

  • March 23, 2007

Research

keywords

  • Phosphatidylinositol 3-Kinases
  • Protein Kinases
  • Proto-Oncogene Proteins c-akt

Identity

Scopus Document Identifier

  • 33947243276

Digital Object Identifier (DOI)

  • 10.1016/j.molcel.2007.03.007

PubMed ID

  • 17386258

Additional Document Info

volume

  • 25

issue

  • 6