ATM: Promoter of metabolic "cost" reduction and "savings" usage during hypoxia through mTORC1 regulation. uri icon

Overview

abstract

  • Cells must sense environmental conditions and adjust to maintain metabolic homeostasis and survive stress conditions; in this issue, Cam et al. (2010) show that the tumor suppressor kinase ATM is activated by hypoxia, phosphorylates and stabilizes HIF-1α, and inhibits mTORC1.

publication date

  • November 24, 2010

Identity

Scopus Document Identifier

  • 78649284221

Digital Object Identifier (DOI)

  • 10.1016/j.molcel.2010.11.013

PubMed ID

  • 21095578

Additional Document Info

volume

  • 40

issue

  • 4