Chromatin dynamics during cellular reprogramming. Review uri icon

Overview

abstract

  • Induced pluripotency is a powerful tool to derive patient-specific stem cells. In addition, it provides a unique assay to study the interplay between transcription factors and chromatin structure. Here, we review the latest insights into chromatin dynamics that are inherent to induced pluripotency. Moreover, we compare and contrast these events with other physiological and pathological processes that involve changes in chromatin and cell state, including germ cell maturation and tumorigenesis. We propose that an integrated view of these seemingly diverse processes could provide mechanistic insights into cell fate transitions in general and might lead to new approaches in regenerative medicine and cancer treatment.

publication date

  • October 24, 2013

Research

keywords

  • Cellular Reprogramming
  • Chromatin

Identity

PubMed Central ID

  • PMC4216318

Scopus Document Identifier

  • 84886859638

Digital Object Identifier (DOI)

  • 10.1038/ncb2816

PubMed ID

  • 24153299

Additional Document Info

volume

  • 502

issue

  • 7472