Apostolou, Eftychia

Publications

Sort by

Co-Author Network

selected publications

Discovery of Competent Chromatin Regions in Human Embryonic Stem Cells. bioRxiv : the preprint server for biology. 2023 Article GET IT
3D enhancer-promoter interactions and multi-connected hubs: Organizational principles and functional roles. Cell reports. 2023 Review GET IT
Times cited: 1
Single-cell analysis of bidirectional reprogramming between early embryonic states reveals mechanisms of differential lineage plasticities. bioRxiv : the preprint server for biology. 2023 Article GET IT
Dynamic network-guided CRISPRi screen reveals CTCF loop-constrained nonlinear enhancer-gene regulatory activity in cell state transitions. bioRxiv : the preprint server for biology. 2023 Article GET IT
Progress and challenges in stem cell biology. Nature cell biology. 2023 Academic Article GET IT
A Knock-In Mouse Model of Thymoma With the GTF2I L424H Mutation. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. 2022 Academic Article GET IT
Times cited: 4
Assessing Specific Networks of Chromatin Interactions with HiChIP. Methods in molecular biology (Clifton, N.J.). 2022 Academic Article GET IT
Times cited: 1
A bipartite element with allele-specific functions safeguards DNA methylation imprints at the Dlk1-Dio3 locus. Developmental cell. 2021 Academic Article GET IT
Times cited: 9
OCT2 pre-positioning facilitates cell fate transition and chromatin architecture changes in humoral immunity. Nature immunology. 2021 Academic Article GET IT
Times cited: 4
Deciphering the Complexity of 3D Chromatin Organization Driving Lymphopoiesis and Lymphoid Malignancies. Frontiers in immunology. 2021 Review GET IT
Times cited: 7
H3K27ac bookmarking promotes rapid post-mitotic activation of the pluripotent stem cell program without impacting 3D chromatin reorganization. Molecular cell. 2021 Academic Article GET IT
Times cited: 31
Histone H1 loss drives lymphoma by disrupting 3D chromatin architecture. Nature. 2020 Academic Article GET IT
Times cited: 95
Dynamic 3D Chromatin Reorganization during Establishment and Maintenance of Pluripotency. Stem cell reports. 2020 Review GET IT
Times cited: 15
Context-Dependent Requirement of Euchromatic Histone Methyltransferase Activity during Reprogramming to Pluripotency. Stem cell reports. 2020 Academic Article GET IT
Times cited: 6
Transcription factors: building hubs in the 3D space. Cell cycle (Georgetown, Tex.). 2020 Review GET IT
Times cited: 24
A Susceptibility Locus on Chromosome 13 Profoundly Impacts the Stability of Genomic Imprinting in Mouse Pluripotent Stem Cells. Cell reports. 2020 Academic Article GET IT
Times cited: 8
EpiMethylTag: simultaneous detection of ATAC-seq or ChIP-seq signals with DNA methylation. Genome biology. 2019 Academic Article GET IT
Times cited: 22
KLF4 is involved in the organization and regulation of pluripotency-associated three-dimensional enhancer networks. Nature cell biology. 2019 Academic Article GET IT
Times cited: 84
Identification of Cancer Drivers at CTCF Insulators in 1,962 Whole Genomes. Cell systems. 2019 Academic Article GET IT
Times cited: 39
TAF5L and TAF6L Maintain Self-Renewal of Embryonic Stem Cells via the MYC Regulatory Network. Molecular cell. 2019 Academic Article GET IT
Times cited: 22
A hPSC-based platform to discover gene-environment interactions that impact human β-cell and dopamine neuron survival. Nature communications. 2018 Academic Article GET IT
Times cited: 20
Cellular trajectories and molecular mechanisms of iPSC reprogramming. Current opinion in genetics & development. 2018 Review GET IT
Times cited: 30
Shaping the Pluripotent Genome: Switches, Borders, and Loops. Cell stem cell. 2018 Comment GET IT
Nascent Induced Pluripotent Stem Cells Efficiently Generate Entirely iPSC-Derived Mice while Expressing Differentiation-Associated Genes. Cell reports. 2018 Academic Article GET IT
Times cited: 8
Widespread Mitotic Bookmarking by Histone Marks and Transcription Factors in Pluripotent Stem Cells. Cell reports. 2017 Academic Article GET IT
Times cited: 78
Expression of type III interferons (IFNλs) and their receptor in Sjögren's syndrome. Clinical and experimental immunology. 2016 Academic Article GET IT
Times cited: 25
The Chromatin Signature of Pluripotency: Establishment and Maintenance. Current stem cell reports. 2016 Review GET IT
Times cited: 86
Local Genome Topology Can Exhibit an Incompletely Rewired 3D-Folding State during Somatic Cell Reprogramming. Cell stem cell. 2016 Academic Article GET IT
Times cited: 87
A Serial shRNA Screen for Roadblocks to Reprogramming Identifies the Protein Modifier SUMO2. Stem cell reports. 2016 Academic Article GET IT
Times cited: 37
PRC2 Is Required to Maintain Expression of the Maternal Gtl2-Rian-Mirg Locus by Preventing De Novo DNA Methylation in Mouse Embryonic Stem Cells. Cell reports. 2015 Academic Article GET IT
Times cited: 47
F-class cells: new routes and destinations for induced pluripotency. Cell stem cell. 2015 Academic Article GET IT
Times cited: 6
Small molecules facilitate rapid and synchronous iPSC generation. Nature methods. 2014 Academic Article GET IT
Times cited: 75
Distinct and combinatorial functions of Jmjd2b/Kdm4b and Jmjd2c/Kdm4c in mouse embryonic stem cell identity. Molecular cell. 2013 Academic Article GET IT
Times cited: 92
Rearranging the chromatin for pluripotency. Cell cycle (Georgetown, Tex.). 2013 Editorial Article GET IT
Times cited: 7
Chromatin dynamics during cellular reprogramming. Nature. 2013 Review GET IT
Times cited: 294
Genome-wide chromatin interactions of the Nanog locus in pluripotency, differentiation, and reprogramming. Cell stem cell. 2013 Academic Article GET IT
Times cited: 164
A molecular roadmap of reprogramming somatic cells into iPS cells. Cell. 2012 Academic Article GET IT
Times cited: 632
Regulation of pluripotency and cellular reprogramming by the ubiquitin-proteasome system. Cell stem cell. 2012 Academic Article GET IT
Times cited: 203
Ascorbic acid prevents loss of Dlk1-Dio3 imprinting and facilitates generation of all-iPS cell mice from terminally differentiated B cells. Nature genetics. 2012 Academic Article GET IT
Times cited: 232
Genomic analysis reveals a novel nuclear factor-κB (NF-κB)-binding site in Alu-repetitive elements. The Journal of biological chemistry. 2011 Academic Article GET IT
Times cited: 47
Stem cells: iPS cells under attack. Nature. 2011 Comment GET IT
Times cited: 29
Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells. Nature biotechnology. 2010 Academic Article GET IT
Times cited: 958
Aberrant silencing of imprinted genes on chromosome 12qF1 in mouse induced pluripotent stem cells. Nature. 2010 Academic Article GET IT
Times cited: 656
Pericentromeric instability and spontaneous emergence of human neoacrocentric and minute chromosomes in the alternative pathway of telomere lengthening. Cancer research. 2008 Academic Article GET IT
Times cited: 20
Virus Infection Induces NF-kappaB-dependent interchromosomal associations mediating monoallelic IFN-beta gene expression. Cell. 2008 Academic Article GET IT
Times cited: 188
Linking differential chromatin loops to transcriptional decisions. Molecular cell. 2008 Comment GET IT
Times cited: 6

more ...

less ...

Research

Sort by

Co-investigator Network

Funding awarded

Characterizing stem cell-like B cell subpopulations and dissecting their role in tumorigenesis awarded by National Cancer Institute Principal Investigator 2023 - 2028
Mark Foundation Emerging Leader Award awarded by The Mark Foundation for Cancer Research Principal Investigator 2021 - 2024
Organizational principles and functional role of 3D enhancer hubs in cell fate decisions awarded by National Institute of General Medical Sciences Principal Investigator 2020 - 2024
Addgene 700134 awarded by Addgene, Inc. Principal Investigator 2022 - 2023
Dissecting mechanisms of epigenetic inheritance of pluripotent stem cell identity awarded by Tri-Institutional Stem Cell Initiative (Weill Cornell) Principal Investigator 2021 - 2023
Multiomics of pluripotent stem cell derived gastruloids awarded by Tri-Institutional Stem Cell Initiative (Weill Cornell) Principal Investigator 2021 - 2023

Dissecting genetic determinants of epigenetic instability in pluripotent stem cells awarded by National Institute of General Medical Sciences Co-Investigator 2022 - 2026
Modeling deficiencies in autism-associated chromatin regulators during human neurogenesis using multipurpose degron alleles awarded by Simons Foundation Autism Research Initiative Co-Investigator 2021 - 2023
Novel approaches to explore principles of epigenetic gene regulation during neurogenesis awarded by Tri-Institutional Stem Cell Initiative (Weill Cornell) Co-Investigator 2020 - 2022

Gene regulatory networks in early lung epithelial cell fate decisions awarded by National Heart, Lung, & Blood Institute Principal Investigator Subaward 2023 - 2027
Structure, Function, and Dynamics of Macro-molecular Complexes that Execute and Regulate Genome Function awarded by National Institute of General Medical Sciences Principal Investigator Subaward 2021 - 2026
Discovery of diabetes-relevant β cell enhancers through 4D enhancer mapping, integrative analysis, and large-scale CRISPRi perturbation screens awarded by National Institute of Diabetes & Digestive & Kidney Diseases Principal Investigator Subaward 2020 - 2025
Epigenetic mechanisms of transcriptional activation of a novel oncogenic ALK variant in cancer awarded by National Cancer Institute Principal Investigator Subaward 2018 - 2024

more ...

less ...

Background

education and training

Ph.D., University of Athens, Faculty of Medicine (Greece) 2009
B.Sc., Aristotle University of Thessaloniki (Greece) 2003

Contact

full name

Eftychia Apostolou

primary email

efa2001@med.cornell.edu

VIVO Weill Cornell Medical College

Eftychia Apostolou Associate Professor of Molecular Biology in Medicine

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

Phone

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email