Role of soluble adenylyl cyclase in mitochondria. Review uri icon

Overview

abstract

  • The soluble adenylyl cyclase (sAC) catalyzes the conversion of ATP into cyclic AMP (cAMP). Recent studies have shed new light on the role of sAC localized in mitochondria and its product cAMP, which drives mitochondrial protein phosphorylation and regulation of the oxidative phosphorylation system and other metabolic enzymes, presumably through the activation of intra-mitochondrial PKA. In this review article, we summarize recent findings on mitochondrial sAC activation by bicarbonate (HCO(3)(-)) and calcium (Ca²⁺) and the effects on mitochondrial metabolism. We also discuss putative mechanisms whereby sAC-mediated mitochondrial protein phosphorylation regulates mitochondrial metabolism. This article is part of a Special Issue entitled: The role of soluble adenylyl cyclase in health and disease.

publication date

  • June 5, 2014

Research

keywords

  • Adenylyl Cyclases
  • Mitochondria

Identity

PubMed Central ID

  • PMC4257896

Scopus Document Identifier

  • 84919393698

Digital Object Identifier (DOI)

  • 10.1016/j.bbadis.2014.05.035

PubMed ID

  • 24907564

Additional Document Info

volume

  • 1842

issue

  • 12 Pt B