Separating neuronal compartments gives clues as to local effect of ubiquitin conjugates in synaptogenesis. uri icon

Overview

abstract

  • Presynaptic differentiation is a critical and poorly understood step in synapse formation. Using compartmentalized culture systems that isolate axons and nascent synapses, Pinto et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201509039) show that the axonal ubiquitin-proteasome system locally regulates the accumulation of ubiquitinated substrates, triggering presynaptic differentiation.

publication date

  • March 28, 2016

Research

keywords

  • Cell Differentiation
  • Hippocampus
  • Polyubiquitin
  • Presynaptic Terminals
  • Proteasome Endopeptidase Complex
  • Ubiquitinated Proteins

Identity

PubMed Central ID

  • PMC4810311

Scopus Document Identifier

  • 84978878337

Digital Object Identifier (DOI)

  • 10.1038/ng1006

PubMed ID

  • 27022088

Additional Document Info

volume

  • 212

issue

  • 7