Upper tract urothelial carcinoma has a luminal-papillary T-cell depleted contexture and activated FGFR3 signaling. Academic Article uri icon

Overview

abstract

  • Upper tract urothelial carcinoma (UTUC) is characterized by a distinctly aggressive clinical phenotype. To define the biological features driving this phenotype, we performed an integrated analysis of whole-exome and RNA sequencing of UTUC. Here we report several key insights from our molecular dissection of this disease: 1) Most UTUCs are luminal-papillary; 2) UTUC has a T-cell depleted immune contexture; 3) High FGFR3 expression is enriched in UTUC and correlates with its T-cell depleted immune microenvironment; 4) Sporadic UTUC is characterized by a lower total mutational burden than urothelial carcinoma of the bladder. Our findings lay the foundation for a deeper understanding of UTUC biology and provide a rationale for the development of UTUC-specific treatment strategies.

publication date

  • July 5, 2019

Research

keywords

  • Carcinoma, Transitional Cell
  • Kidney Neoplasms
  • Receptor, Fibroblast Growth Factor, Type 3
  • T-Lymphocytes
  • Ureteral Neoplasms

Identity

PubMed Central ID

  • PMC6611775

Scopus Document Identifier

  • 85068463107

Digital Object Identifier (DOI)

  • 10.12688/f1000research.9090.1

PubMed ID

  • 31278255

Additional Document Info

volume

  • 10

issue

  • 1