Advances in PSMA theranostics. Academic Article uri icon

Overview

abstract

  • The validation of prostate specific membrane antigen (PSMA) as a molecular target in metastatic castration-resistant prostate cancer has stimulated the development of multiple classes of theranostic ligands that specifically target PSMA. Theranostic ligands are used to image disease or selectively deliver cytotoxic radioactivity to cells expressing PSMA according to the radioisotope conjugated to the ligand. PSMA theranostics is a rapidly advancing field that is now integrating into clinical management of prostate cancer patients. In this review we summarize published research describing the biological role(s) and activity of PSMA, highlight the most clinically advanced PSMA targeting molecules and biomacromolecules, and identify next generation PSMA ligands that aim to further improve treatment efficacy. The goal of this review is to provide a comprehensive assessment of the current state-of-play and a roadmap to achieving further advances in PSMA theranostics.

publication date

  • May 18, 2022

Identity

PubMed Central ID

  • PMC9123266

Scopus Document Identifier

  • 85135302398

Digital Object Identifier (DOI)

  • 10.2967/jnumed.121.262713

PubMed ID

  • 35597190

Additional Document Info

volume

  • 22