A cellular oncogene (c-Ki-ras) is amplified, overexpressed, and located within karyotypic abnormalities in mouse adrenocortical tumour cells. Academic Article uri icon

Overview

abstract

  • The cellular oncogene c-Ki-ras is amplified 30- to 60-fold in cells of the mouse adrenocortical tumour Y1. The amplified oncogene is located in double minute chromosomes and in a homogeneously staining chromosomal region, common karyotypical anomalies of tumour cells. The amounts of c-Ki-ras specific mRNA and of the protein (p21) encoded by the amplified gene are correspondingly elevated. Amplification and enhanced expression of cellular oncogenes may contribute to the genesis and/or maintenance of at least some naturally occurring tumours.

publication date

  • June 1, 1983

Research

keywords

  • Adrenal Cortex Neoplasms
  • Gene Amplification
  • Oncogenes

Identity

Scopus Document Identifier

  • 0020576168

Digital Object Identifier (DOI)

  • 10.1038/303497a0

PubMed ID

  • 6304530

Additional Document Info

volume

  • 303

issue

  • 5917