CD14 is a pattern recognition receptor. Academic Article uri icon

Overview

abstract

  • Septic shock caused by a diverse group of bacterial pathogens is a serious human disease. Recognition of bacterial envelope constituents is one mechanism used by mammalian cells to initiate responses leading to bacterial killing or, unfortunately, responses that also cause fatal septic shock. Here we show that CD14 plays a key role in initiating cell activation by a group of bacterial envelope components from Gram-negative and Gram-positive microorganisms, as well as mycobacteria. We propose that CD14 is a receptor used by mammalian cells to recognize and signal responses to a diverse array of bacterial constituents. This finding defines the molecular basis for innate microbial immunity; implicit in these findings are new possibilities for therapeutics.

publication date

  • September 1, 1994

Research

keywords

  • Antigens, Bacterial
  • Antigens, CD
  • Antigens, Differentiation, Myelomonocytic
  • Receptors, Immunologic

Identity

Scopus Document Identifier

  • 0028501020

Digital Object Identifier (DOI)

  • 10.1016/1074-7613(94)90093-0

PubMed ID

  • 7534618

Additional Document Info

volume

  • 1

issue

  • 6