Zhou, Pengbo

Publications

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selected publications

Genetic Profiling of African American Patients With Prostatic Adenocarcinoma Metastatic to the Lymph Nodes: A Pilot Study. Archives of pathology & laboratory medicine. 2023 Academic Article GET IT
A common intronic single nucleotide variant modifies PKD1 expression level. Clinical genetics. 2022 Academic Article GET IT
UBR5 targets tumor suppressor CDC73 proteolytically to promote aggressive breast cancer. Cell death & disease. 2022 Academic Article GET IT
Times cited: 2
G3BP1 modulates SPOP to promote prostate tumorigenesis. Molecular & cellular oncology. 2022 Academic Article GET IT
Times cited: 467
G3BP1 inhibits Cul3^SPOP to amplify AR signaling and promote prostate cancer. Nature communications. 2021 Academic Article GET IT
Times cited: 6
Cullin4 E3 Ubiquitin Ligases Regulate Male Gonocyte Migration, Proliferation and Blood-Testis Barrier Homeostasis. Cells. 2021 Academic Article GET IT
Times cited: 1
Engineering Single Pan-Specific Ubiquibodies for Targeted Degradation of All Forms of Endogenous ERK Protein Kinase. ACS synthetic biology. 2021 Academic Article GET IT
Times cited: 4
Roles of the ubiquitin ligase CUL4B and ADP-ribosyltransferase TiPARP in TCDD-induced nuclear export and proteasomal degradation of the transcription factor AHR. The Journal of biological chemistry. 2021 Academic Article GET IT
Times cited: 9
CUL4^high Lung Adenocarcinomas Are Dependent on the CUL4-p21 Ubiquitin Signaling for Proliferation and Survival. The American journal of pathology. 2021 Academic Article GET IT
CRL4 Ubiquitin Pathway and DNA Damage Response. Advances in experimental medicine and biology. 2020 Review GET IT
Times cited: 6
The emerging role for Cullin 4 family of E3 ligases in tumorigenesis. Biochimica et biophysica acta. Reviews on cancer. 2018 Review GET IT
Times cited: 43
Distinct Biological Types of Ocular Adnexal Sebaceous Carcinoma: HPV-Driven and Virus-Negative Tumors Arise through Nonoverlapping Molecular-Genetic Alterations. Clinical cancer research : an official journal of the American Association for Cancer Research. 2018 Academic Article GET IT
Times cited: 31
Poly(ADP-ribose) polymerase 1 escorts XPC to UV-induced DNA lesions during nucleotide excision repair. Proceedings of the National Academy of Sciences of the United States of America. 2017 Academic Article GET IT
Times cited: 34
Recombinant TAT-BMI-1 fusion protein induces ex vivo expansion of human umbilical cord blood-derived hematopoietic stem cells. Oncotarget. 2017 Academic Article GET IT
Times cited: 17
Dysregulation of CUL4A and CUL4B Ubiquitin Ligases in Lung Cancer. The Journal of biological chemistry. 2016 Academic Article GET IT
Times cited: 34
Cell Autonomous and Nonautonomous Function of CUL4B in Mouse Spermatogenesis. The Journal of biological chemistry. 2016 Academic Article GET IT
Times cited: 20
SPOP mutation leads to genomic instability in prostate cancer. eLife. 2015 Academic Article GET IT
Times cited: 129
Distinct and overlapping functions of the cullin E3 ligase scaffolding proteins CUL4A and CUL4B. Gene. 2015 Review GET IT
Times cited: 69
Methods: A small-molecule SMASh hit. Nature chemical biology. 2015 Comment GET IT
Times cited: 2
Akt Phosphorylates Wnt Coactivator and Chromatin Effector Pygo2 at Serine 48 to Antagonize Its Ubiquitin/Proteasome-mediated Degradation. The Journal of biological chemistry. 2015 Academic Article GET IT
Times cited: 8
CDK4/6 Inhibitor PD 0332991 Sensitizes Acute Myeloid Leukemia to Cytarabine-Mediated Cytotoxicity. Cancer research. 2015 Academic Article GET IT
Times cited: 39
Merlin/NF2 loss-driven tumorigenesis linked to CRL4(DCAF1)-mediated inhibition of the hippo pathway kinases Lats1 and 2 in the nucleus. Cancer cell. 2014 Academic Article GET IT
Times cited: 166
The transcription factor TFII-I promotes DNA translesion synthesis and genomic stability. PLoS genetics. 2014 Academic Article GET IT
Times cited: 33
Axl receptor tyrosine kinase expression in breast cancer. Journal of clinical pathology. 2014 Academic Article GET IT
Times cited: 42
Comprehensive molecular characterization of urothelial bladder carcinoma. Nature. 2014 Academic Article GET IT
Times cited: 2179
Histone cleavage as a mechanism for epigenetic regulation: current insights and perspectives. Current molecular medicine. 2014 Review GET IT
Times cited: 33
A novel function of CRL4(Cdt2): regulation of the subunit structure of DNA polymerase δ in response to DNA damage and during the S phase. The Journal of biological chemistry. 2013 Academic Article GET IT
Times cited: 47
The CUL4A ubiquitin ligase is a potential therapeutic target in skin cancer and other malignancies. Chinese journal of cancer. 2013 Review GET IT
Times cited: 10
Prostate cancer-associated mutations in speckle-type POZ protein (SPOP) regulate steroid receptor coactivator 3 protein turnover. Proceedings of the National Academy of Sciences of the United States of America. 2013 Academic Article GET IT
Times cited: 184
Improved ex vivo expansion of adult hematopoietic stem cells by overcoming CUL4-mediated degradation of HOXB4. Blood. 2013 Academic Article GET IT
Times cited: 31
Engineering a single ubiquitin ligase for the selective degradation of all activated ErbB receptor tyrosine kinases. Oncogene. 2013 Academic Article GET IT
Times cited: 11
The Cul4A-DDB1 E3 ubiquitin ligase complex represses p73 transcriptional activity. Oncogene. 2012 Academic Article GET IT
Times cited: 25
Essential role of the CUL4B ubiquitin ligase in extra-embryonic tissue development during mouse embryogenesis. Cell research. 2012 Academic Article GET IT
Times cited: 53
Pathogenic Role of the CRL4 Ubiquitin Ligase in Human Disease. Frontiers in oncology. 2012 Academic Article GET IT
Times cited: 15
Merlin/NF2 functions upstream of the nuclear E3 ubiquitin ligase CRL4DCAF1 to suppress oncogenic gene expression. Science signaling. 2011 Academic Article GET IT
Times cited: 32
Maximizing target protein ablation by integration of RNAi and protein knockout. Cell research. 2011 Letter GET IT
Times cited: 6
The E3 ubiquitin ligase Cullin 4A regulates meiotic progression in mouse spermatogenesis. Developmental biology. 2011 Academic Article GET IT
Times cited: 65
RNA export factor RAE1 contributes to NUP98-HOXA9-mediated leukemogenesis. Cell cycle (Georgetown, Tex.). 2011 Academic Article GET IT
Times cited: 36
SETting the clock for histone H4 monomethylation. Molecular cell. 2010 Comment GET IT
Times cited: 9
Navigating the nucleotide excision repair threshold. Journal of cellular physiology. 2010 Review GET IT
Times cited: 21
Cullins and cancer. Genes & cancer. 2010 Academic Article GET IT
Times cited: 67
Merlin/NF2 suppresses tumorigenesis by inhibiting the E3 ubiquitin ligase CRL4(DCAF1) in the nucleus. Cell. 2010 Academic Article GET IT
Times cited: 250
CUL4A abrogation augments DNA damage response and protection against skin carcinogenesis. Molecular cell. 2009 Academic Article GET IT
Times cited: 155
Regulation of DNA damage response pathways by the cullin-RING ubiquitin ligases. DNA repair. 2009 Review GET IT
Times cited: 49
DCAFs, the missing link of the CUL4-DDB1 ubiquitin ligase. Molecular cell. 2007 Review GET IT
Times cited: 331
NUP98 dysregulation in myeloid leukemogenesis. Annals of the New York Academy of Sciences. 2007 Review GET IT
Times cited: 59
DDB1 is essential for genomic stability in developing epidermis. Proceedings of the National Academy of Sciences of the United States of America. 2007 Academic Article GET IT
Times cited: 55
Enforced expression of NUP98-HOXA9 in human CD34(+) cells enhances stem cell proliferation. Cancer research. 2006 Academic Article GET IT
Times cited: 62
Deletion of DDB1 in mouse brain and lens leads to p53-dependent elimination of proliferating cells. Cell. 2006 Academic Article GET IT
Times cited: 124
A kinase-independent function of c-Abl in promoting proteolytic destruction of damaged DNA binding proteins. Molecular cell. 2006 Academic Article GET IT
Times cited: 50
REGgamma: a shortcut to destruction. Cell. 2006 Comment GET IT
Times cited: 19
Structure of DDB1 in complex with a paramyxovirus V protein: viral hijack of a propeller cluster in ubiquitin ligase. Cell. 2006 Academic Article GET IT
Times cited: 212
Estimating the growth rates of primary lung tumours from samples with missing measurements. Statistics in medicine. 2005 Academic Article GET IT
Times cited: 6
Targeted protein degradation. Current opinion in chemical biology. 2005 Review GET IT
Times cited: 39
Ectopic targeting of substrates to the ubiquitin pathway. Methods in enzymology. 2005 Academic Article GET IT
Times cited: 2
Pharmacoproteomic analysis of prechemotherapy and postchemotherapy plasma samples from patients receiving neoadjuvant or adjuvant chemotherapy for breast carcinoma. Cancer. 2004 Academic Article GET IT
Times cited: 94
Transient in utero knockout (TIUKO) of C-MYC affects late lung and intestinal development in the mouse. BMC developmental biology. 2004 Academic Article GET IT
Times cited: 23
Determining protein half-lives. Methods in molecular biology (Clifton, N.J.). 2004 Academic Article GET IT
Times cited: 65
CUL-4A stimulates ubiquitylation and degradation of the HOXA9 homeodomain protein. The EMBO journal. 2003 Academic Article GET IT
Times cited: 63
Exploring the functional complexity of cellular proteins by protein knockout. Proceedings of the National Academy of Sciences of the United States of America. 2003 Academic Article GET IT
Times cited: 46
A protein knockdown strategy to study the function of beta-catenin in tumorigenesis. BMC molecular biology. 2003 Academic Article GET IT
Times cited: 69
UV-damaged DNA-binding proteins are targets of CUL-4A-mediated ubiquitination and degradation. The Journal of biological chemistry. 2001 Academic Article GET IT
Times cited: 135
Harnessing the ubiquitination machinery to target the degradation of specific cellular proteins. Molecular cell. 2000 Academic Article GET IT
Times cited: 136
The hPLIC proteins may provide a link between the ubiquitination machinery and the proteasome. Molecular cell. 2000 Academic Article GET IT
Times cited: 303
Ubiquitination and degradation of the substrate recognition subunits of SCF ubiquitin-protein ligases. Molecular cell. 1998 Academic Article GET IT
Times cited: 225
p35, the neuronal-specific activator of cyclin-dependent kinase 5 (Cdk5) is degraded by the ubiquitin-proteasome pathway. The Journal of biological chemistry. 1998 Academic Article GET IT
Times cited: 262
A system for gene cloning and manipulation in the yeast Candida glabrata. Gene. 1994 Academic Article GET IT
Times cited: 39
Rapid transcriptional autoregulation of a yeast metalloregulatory transcription factor is essential for high-level copper detoxification. Genes & development. 1993 Academic Article GET IT
Times cited: 45
Copper and gene regulation in yeast. BioFactors (Oxford, England). 1993 Review GET IT
Times cited: 33
Expression of a yeast metallothionein gene family is activated by a single metalloregulatory transcription factor. Molecular and cellular biology. 1992 Academic Article GET IT
Times cited: 64
Isolation of a metal-activated transcription factor gene from Candida glabrata by complementation in Saccharomyces cerevisiae. Proceedings of the National Academy of Sciences of the United States of America. 1991 Academic Article GET IT
Times cited: 85

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Research

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Funding awarded

Addgene 703531 awarded by Addgene, Inc. Principal Investigator 2022 - 2023
G3BP1 Suppresses SPOP Ubiquitin Ligase to Promote Prostate Tumorigenesis awarded by National Cancer Institute Principal Investigator 2018 - 2023
Harnessing the CRL4 Ubiquitin Ligase for Antagonizing Colorectal Carcinogenesis awarded by National Cancer Institute Principal Investigator 2017 - 2023

Clinical and Translational Science Center - UL1 awarded by National Center for Advancing Translational Sciences Co-Investigator 2022 - 2027
Coordinate Regulation of Oncogenic Signaling Pathways in SPOP Mutant Prostate Cancer awarded by National Cancer Institute Co-Investigator 2018 - 2025

UBR5''s Mechanisms of Action in Tumorigenesis and Immunoregulation awarded by National Cancer Institute Key Personnel 2023 - 2028

Culnexin Incoming Subcontract SBIR Research Agreement (PT record) awarded by National Cancer Institute Principal Investigator Subaward 2021 - 2023
NExT Proposal S21-168 - CUL4 Project awarded by National Cancer Institute Principal Investigator Subaward 2021 - 2023

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Background

education and training

Ph.D., University of Michigan Medical School 1993
B.S., Peking University (China) 1987

Contact

full name

Pengbo Zhou

primary email

pez2001@med.cornell.edu

VIVO Weill Cornell Medical College

Pengbo Zhou Professor of Pathology and Laboratory Medicine

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email