Dow, Lukas Edward

Publications

Sort by

Co-Author Network

selected publications

Novel genetically engineered mouse models for clear cell renal cell carcinoma. Scientific reports. 2023 Academic Article GET IT
Obesity promotes breast epithelium DNA damage in women carrying a germline mutation in BRCA1 or BRCA2. Science translational medicine. 2023 Academic Article GET IT
Times cited: 2
Comprehensive microRNA analysis across genome-edited colorectal cancer organoid models reveals miR-24 as a candidate regulator of cell survival. BMC genomics. 2022 Academic Article GET IT
Endogenous spacing enables co-processing of microRNAs and efficient combinatorial RNAi. Cell reports methods. 2022 Academic Article GET IT
Times cited: 219
Chromatin profiles classify castration-resistant prostate cancers suggesting therapeutic targets. Science (New York, N.Y.). 2022 Academic Article GET IT
Times cited: 22
A preclinical platform for assessing antitumor effects and systemic toxicities of cancer drug targets. Proceedings of the National Academy of Sciences of the United States of America. 2022 Academic Article GET IT
Times cited: 2
CRISPR in cancer biology and therapy. Nature reviews. Cancer. 2022 Review GET IT
Times cited: 61
Base editing sensor libraries for high-throughput engineering and functional analysis of cancer-associated single nucleotide variants. Nature biotechnology. 2022 Academic Article GET IT
Times cited: 15
Mitochondrial Ndufa4l2 Enhances Deposition of Lipids and Expression of Ca9 in the TRACK Model of Early Clear Cell Renal Cell Carcinoma. Frontiers in oncology. 2021 Academic Article GET IT
Times cited: 242
RB depletion is required for the continuous growth of tumors initiated by loss of RB. PLoS genetics. 2021 Academic Article GET IT
Times cited: 2
Engineering chromosome rearrangements in cancer. Disease models & mechanisms. 2021 Review GET IT
Times cited: 2
WNT as a Driver and Dependency in Cancer. Cancer discovery. 2021 Review GET IT
Times cited: 52
Dietary fructose improves intestinal cell survival and nutrient absorption. Nature. 2021 Academic Article GET IT
Times cited: 76
KRAS mutant rectal cancer cells interact with surrounding fibroblasts to deplete the extracellular matrix. Molecular oncology. 2021 Academic Article GET IT
Times cited: 4
Revealing ARID1A Function in Gastric Cancer from the Bottom Up. Cancer discovery. 2021 Comment GET IT
Times cited: 1
Inducible hepatic expression of CREBH mitigates diet-induced obesity, insulin resistance, and hepatic steatosis in mice. The Journal of biological chemistry. 2021 Academic Article GET IT
Times cited: 4
Exogenous and Endogenous Sources of Serine Contribute to Colon Cancer Metabolism, Growth, and Resistance to 5-Fluorouracil. Cancer research. 2021 Academic Article GET IT
Times cited: 40
EpCAM (CD326) Regulates Intestinal Epithelial Integrity and Stem Cells via Rho-Associated Kinase. Cells. 2021 Academic Article GET IT
Times cited: 5
Cerebral cavernous malformations are driven by ADAMTS5 proteolysis of versican. The Journal of experimental medicine. 2020 Academic Article GET IT
Times cited: 21
Adaptable haemodynamic endothelial cells for organogenesis and tumorigenesis. Nature. 2020 Academic Article GET IT
Times cited: 102
An In Vivo Kras Allelic Series Reveals Distinct Phenotypes of Common Oncogenic Variants. Cancer discovery. 2020 Academic Article GET IT
Times cited: 38
Exploiting the Therapeutic Interaction of WNT Pathway Activation and Asparaginase for Colorectal Cancer Therapy. Cancer discovery. 2020 Academic Article GET IT
Times cited: 25
Three-dimensional growth of breast cancer cells potentiates the anti-tumor effects of unacylated ghrelin and AZP-531. eLife. 2020 Academic Article GET IT
Times cited: 5
Lineage Reversion Drives WNT Independence in Intestinal Cancer. Cancer discovery. 2020 Academic Article GET IT
Times cited: 29
Base editing goes into hyperdrive. Nature cell biology. 2020 Comment GET IT
Generation of focal mutations and large genomic deletions in the pancreas using inducible in vivo genome editing. Carcinogenesis. 2020 Academic Article GET IT
Times cited: 5
Zonation of Ribosomal DNA Transcription Defines a Stem Cell Hierarchy in Colorectal Cancer. Cell stem cell. 2020 Academic Article GET IT
Times cited: 40
Somatic Tissue Engineering in Mouse Models Reveals an Actionable Role for WNT Pathway Alterations in Prostate Cancer Metastasis. Cancer discovery. 2020 Academic Article GET IT
Times cited: 27
GO: a functional reporter system to identify and enrich base editing activity. Nucleic acids research. 2020 Academic Article GET IT
Times cited: 15
Detection of Marker-Free Precision Genome Editing and Genetic Variation through the Capture of Genomic Signatures. Cell reports. 2020 Academic Article GET IT
Times cited: 4
In situ CRISPR-Cas9 base editing for the development of genetically engineered mouse models of breast cancer. The EMBO journal. 2020 Academic Article GET IT
Times cited: 27
Tankyrase inhibition sensitizes cells to CDK4 blockade. PloS one. 2019 Academic Article GET IT
Times cited: 4
Adipsin preserves beta cells in diabetic mice and associates with protection from type 2 diabetes in humans. Nature medicine. 2019 Academic Article GET IT
Times cited: 76
A rectal cancer organoid platform to study individual responses to chemoradiation. Nature medicine. 2019 Academic Article GET IT
Times cited: 239
Preclinical murine platform to evaluate therapeutic countermeasures against radiation-induced gastrointestinal syndrome. Proceedings of the National Academy of Sciences of the United States of America. 2019 Academic Article GET IT
Times cited: 23
Distinct Colorectal Cancer-Associated APC Mutations Dictate Response to Tankyrase Inhibition. Cancer discovery. 2019 Academic Article GET IT
Times cited: 41
Systemic silencing of PHD2 causes reversible immune regulatory dysfunction. The Journal of clinical investigation. 2019 Academic Article GET IT
Times cited: 23
PIP4Ks Suppress Insulin Signaling through a Catalytic-Independent Mechanism. Cell reports. 2019 Academic Article GET IT
Times cited: 18
Base editing the mammalian genome. Methods (San Diego, Calif.). 2019 Review GET IT
Times cited: 10
Adenine base editing in an adult mouse model of tyrosinaemia. Nature biomedical engineering. 2019 Academic Article GET IT
Times cited: 99
Murine Liver Organoids as a Genetically Flexible System to Study Liver Cancer In Vivo and In Vitro. Hepatology communications. 2019 Academic Article GET IT
Times cited: 21
Genetic Liver-Specific AMPK Activation Protects against Diet-Induced Obesity and NAFLD. Cell reports. 2019 Academic Article GET IT
Times cited: 142
CRISPR: Stressed about p53?. Trends in molecular medicine. 2018 Comment GET IT
Times cited: 6
Optimized base editors enable efficient editing in cells, organoids and mice. Nature biotechnology. 2018 Academic Article GET IT
Times cited: 196
R-Spondin chromosome rearrangements drive Wnt-dependent tumour initiation and maintenance in the intestine. Nature communications. 2017 Academic Article GET IT
Times cited: 77
Transplantation of engineered organoids enables rapid generation of metastatic mouse models of colorectal cancer. Nature biotechnology. 2017 Academic Article GET IT
Times cited: 156
Wnt Signaling and Colorectal Cancer. Current colorectal cancer reports. 2017 Academic Article GET IT
Times cited: 173
Somatic Genome Editing Goes Viral. Trends in molecular medicine. 2016 Academic Article GET IT
Times cited: 2
p53-Dependent Nestin Regulation Links Tumor Suppression to Cellular Plasticity in Liver Cancer. Cell. 2016 Academic Article GET IT
Times cited: 11
Pten loss promotes MAPK pathway dependency in HER2/neu breast carcinomas. Proceedings of the National Academy of Sciences of the United States of America. 2016 Academic Article GET IT
Times cited: 48
Immunofluorescent Staining of Mouse Intestinal Stem Cells. Bio-protocol. 2016 Academic Article GET IT
Isolation, Culture, and Maintenance of Mouse Intestinal Stem Cells. Bio-protocol. 2016 Academic Article GET IT
Interleukin-22 promotes intestinal-stem-cell-mediated epithelial regeneration. Nature. 2015 Academic Article GET IT
Times cited: 657
Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH. Science (New York, N.Y.). 2015 Academic Article GET IT
Times cited: 612
Modeling Disease In Vivo With CRISPR/Cas9. Trends in molecular medicine. 2015 Review GET IT
Times cited: 79
Transcriptional plasticity promotes primary and acquired resistance to BET inhibition. Nature. 2015 Academic Article GET IT
Times cited: 364
Apc Restoration Promotes Cellular Differentiation and Reestablishes Crypt Homeostasis in Colorectal Cancer. Cell. 2015 Academic Article GET IT
Times cited: 349
The polarity protein Scribble regulates myelination and remyelination in the central nervous system. PLoS biology. 2015 Academic Article GET IT
Times cited: 27
Inducible in vivo genome editing with CRISPR-Cas9. Nature biotechnology. 2015 Academic Article GET IT
Times cited: 364
Inducible in vivo silencing of Brd4 identifies potential toxicities of sustained BET protein inhibition. Cell reports. 2014 Academic Article GET IT
Times cited: 126
p53-dependent Nestin regulation links tumor suppression to cellular plasticity in liver cancer. Cell. 2014 Academic Article GET IT
Times cited: 145
Conditional reverse tet-transactivator mouse strains for the efficient induction of TRE-regulated transgenes in mice. PloS one. 2014 Academic Article GET IT
Times cited: 50
A modular and flexible ESC-based mouse model of pancreatic cancer. Genes & development. 2014 Academic Article GET IT
Times cited: 60
Suppression of eukaryotic initiation factor 4E prevents chemotherapy-induced alopecia. BMC pharmacology & toxicology. 2013 Academic Article GET IT
Times cited: 8
Creating transgenic shRNA mice by recombinase-mediated cassette exchange. Cold Spring Harbor protocols. 2013 Academic Article GET IT
Times cited: 5
Variability of inducible expression across the hematopoietic system of tetracycline transactivator transgenic mice. PloS one. 2013 Academic Article GET IT
Times cited: 19
Life in the fast lane: mammalian disease models in the genomics era. Cell. 2012 Academic Article GET IT
Times cited: 63
A pipeline for the generation of shRNA transgenic mice. Nature protocols. 2012 Academic Article GET IT
Times cited: 121
SCRIB expression is deregulated in human prostate cancer, and its deficiency in mice promotes prostate neoplasia. The Journal of clinical investigation. 2011 Academic Article GET IT
Times cited: 134
Reversible suppression of an essential gene in adult mice using transgenic RNA interference. Proceedings of the National Academy of Sciences of the United States of America. 2011 Academic Article GET IT
Times cited: 46
A rapid and scalable system for studying gene function in mice using conditional RNA interference. Cell. 2011 Academic Article GET IT
Times cited: 241
Toolkit for evaluating genes required for proliferation and survival using tetracycline-regulated RNAi. Nature biotechnology. 2010 Academic Article GET IT
Times cited: 204
Loss of human Scribble cooperates with H-Ras to promote cell invasion through deregulation of MAPK signalling. Oncogene. 2008 Academic Article GET IT
Times cited: 136
Polarity regulators and the control of epithelial architecture, cell migration, and tumorigenesis. International review of cytology. 2007 Review GET IT
Times cited: 102
The Scribble and Par complexes in polarity and migration: friends or foes?. Trends in cell biology. 2006 Review GET IT
Times cited: 121
The tumour-suppressor Scribble dictates cell polarity during directed epithelial migration: regulation of Rho GTPase recruitment to the leading edge. Oncogene. 2006 Academic Article GET IT
Times cited: 149
A network of PDZ-containing proteins regulates T cell polarity and morphology during migration and immunological synapse formation. Immunity. 2005 Academic Article GET IT
Times cited: 214
hScrib is a functional homologue of the Drosophila tumour suppressor Scribble. Oncogene. 2003 Academic Article GET IT
Times cited: 97

more ...

less ...

Research

Sort by

Co-investigator Network

Funding awarded

Tumor selective inhibition of the WNT pathway awarded by National Cancer Institute Principal Investigator 2022 - 2027
Defining the impact of Kras mutational heterogeneity on the tumor microenvironment in pancreatic cancer awarded by United States Department of Defense Principal Investigator 2023 - 2026
In Vivo Base Editing for Precision Oncology Models awarded by National Cancer Institute Principal Investigator 2019 - 2024
Identifying acquired vulnerabilities driven by lineage plasticity and drug resistance in CRC awarded by Starr Cancer Consortium Principal Investigator 2023 - 2023
Defining the Genetic Determinants of Response to B-Catenin Blockade in CRC awarded by Fog Pharmaceuticals, Inc. Principal Investigator 2022 - 2023
Revolution Medicines, Inc. Biopharma awarded by Revolution Medicines, Inc. Principal Investigator 2020 - 2023
Progression, response, and resistance of RSPO fusion colorectal cancer awarded by National Cancer Institute Principal Investigator 2018 - 2023

Modeling Hepatoblastoma using pluripotent stem cell derived hepatocyte-like cells awarded by National Cancer Institute Co-Investigator 2019 - 2024

Differential role of different NAD+ kinase Isoforms in melanoma metastasis awarded by National Cancer Institute Key Personnel 2022 - 2027
Interrogating the role of mutant KRAS allelic imbalance and co-mutated genes in targeted therapy response of NSCLC awarded by National Cancer Institute Key Personnel 2021 - 2025
Investigating the non-cell autonomous immune effects of mutant p53 in pancreatic cancer awarded by National Cancer Institute Key Personnel 2021 - 2024

Biology of R-Spondin-Induced Sensitization to Asparaginase in Colorectal Cancer awarded by Boston Children''s Hospital (Children''s Hospital Corporation) Principal Investigator Subaward 2021 - 2026

more ...

less ...

Background

education and training

Ph.D., University of Melbourne (Australia) 2006
B.Sc., University of Melbourne (Australia) 2002

Contact

full name

Lukas Edward Dow

primary email

lud2005@med.cornell.edu

VIVO Weill Cornell Medical College

Lukas Edward Dow Associate Professor of Biochemistry in Medicine

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

Phone

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email