Lue, Neal F

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Orchestrating nucleic acid-protein interactions at chromosome ends: telomerase mechanisms come into focus. Nature structural & molecular biology. 2023 Review GET IT
Times cited: 11
Histone demethylase KDM2A is a selective vulnerability of cancers relying on alternative telomere maintenance. Nature communications. 2023 Academic Article GET IT
Histone demethylase KDM2A is a selective vulnerability of cancers relying on alternative telomere maintenance. bioRxiv : the preprint server for biology. 2023 Article GET IT
Molecular architecture and oligomerization of Candida glabrata Cdc13 underpin its telomeric DNA-binding and unfolding activity. Nucleic acids research. 2023 Academic Article GET IT
Connecting telomere maintenance and regulation to the developmental origin and differentiation states of neuroblastoma tumor cells. Journal of hematology & oncology. 2022 Review GET IT
Times cited: 1
Ustilago maydis telomere protein Pot1 harbors an extra N-terminal OB fold and regulates homology-directed DNA repair factors in a dichotomous and context-dependent manner. PLoS genetics. 2022 Academic Article GET IT
Times cited: 2
Reciprocal impacts of telomerase activity and ADRN/MES differentiation state in neuroblastoma tumor biology. Communications biology. 2021 Academic Article GET IT
Times cited: 1
Duplex Telomere-Binding Proteins in Fungi With Canonical Telomere Repeats: New Lessons in the Rapid Evolution of Telomere Proteins. Frontiers in genetics. 2021 Review GET IT
Times cited: 125
Structurally distinct telomere-binding proteins in Ustilago maydis execute non-overlapping functions in telomere replication, recombination, and protection. Communications biology. 2020 Academic Article GET IT
Times cited: 4
Telomere Trimming and DNA Damage as Signatures of High Risk Neuroblastoma. Neoplasia (New York, N.Y.). 2019 Academic Article GET IT
Times cited: 9
Single telomere length analysis in Ustilago maydis, a high-resolution tool for examining fungal telomere length distribution and C-strand 5'-end processing. Microbial cell (Graz, Austria). 2018 Academic Article GET IT
Times cited: 15
Direct observation of nucleic acid binding dynamics by the telomerase essential N-terminal domain. Nucleic acids research. 2018 Academic Article GET IT
Times cited: 7
Evolving Linear Chromosomes and Telomeres: A C-Strand-Centric View. Trends in biochemical sciences. 2018 Review GET IT
Times cited: 26
The mechanisms of K. lactis Cdc13 in telomere DNA-binding and telomerase regulation. DNA repair. 2017 Academic Article GET IT
Times cited: 1
Contributions of recombination and repair proteins to telomere maintenance in telomerase-positive and negative Ustilago maydis. Molecular microbiology. 2017 Academic Article GET IT
Times cited: 6
STN1-POLA2 interaction provides a basis for primase-pol α stimulation by human STN1. Nucleic acids research. 2017 Academic Article GET IT
Times cited: 27
Analysis of Yeast Telomerase by Primer Extension Assays. Methods in molecular biology (Clifton, N.J.). 2017 Academic Article GET IT
Telomere recombination pathways: tales of several unhappy marriages. Current genetics. 2016 Review GET IT
Times cited: 16
Mre11 and Blm-Dependent Formation of ALT-Like Telomeres in Ku-Deficient Ustilago maydis. PLoS genetics. 2015 Academic Article GET IT
Times cited: 17
Telomere DNA recognition in Saccharomycotina yeast: potential lessons for the co-evolution of ssDNA and dsDNA-binding proteins and their target sites. Frontiers in genetics. 2015 Review GET IT
Times cited: 31
Combinatorial recognition of a complex telomere repeat sequence by the Candida parapsilosis Cdc13AB heterodimer. Nucleic acids research. 2015 Academic Article GET IT
Times cited: 7
Fungal Ku prevents permanent cell cycle arrest by suppressing DNA damage signaling at telomeres. Nucleic acids research. 2015 Academic Article GET IT
Times cited: 14
The CDC13-STN1-TEN1 complex stimulates Pol α activity by promoting RNA priming and primase-to-polymerase switch. Nature communications. 2014 Academic Article GET IT
Times cited: 53
SLX4 assembles a telomere maintenance toolkit by bridging multiple endonucleases with telomeres. Cell reports. 2013 Academic Article GET IT
Times cited: 88
Duplication and functional specialization of the telomere-capping protein Cdc13 in Candida species. The Journal of biological chemistry. 2013 Academic Article GET IT
Times cited: 17
Brh2 and Rad51 promote telomere maintenance in Ustilago maydis, a new model system of DNA repair proteins at telomeres. DNA repair. 2013 Academic Article GET IT
Times cited: 15
The telomere capping complex CST has an unusual stoichiometry, makes multipartite interaction with G-Tails, and unfolds higher-order G-tail structures. PLoS genetics. 2013 Academic Article GET IT
Times cited: 32
A popular engagement at the ends. Nature structural & molecular biology. 2013 Article GET IT
Times cited: 8
Loss of ATRX, genome instability, and an altered DNA damage response are hallmarks of the alternative lengthening of telomeres pathway. PLoS genetics. 2012 Academic Article GET IT
Times cited: 429
Functional analysis of the single Est1/Ebs1 homologue in Kluyveromyces lactis reveals roles in both telomere maintenance and rapamycin resistance. Eukaryotic cell. 2012 Academic Article GET IT
Times cited: 3
Telomerase and retrotransposons: reverse transcriptases that shaped genomes. Proceedings of the National Academy of Sciences of the United States of America. 2011 Conference Paper GET IT
Times cited: 37
Analyses of Candida Cdc13 orthologues revealed a novel OB fold dimer arrangement, dimerization-assisted DNA binding, and substantial structural differences between Cdc13 and RPA70. Molecular and cellular biology. 2011 Academic Article GET IT
Times cited: 23
The Candida albicans Ku70 modulates telomere length and structure by regulating both telomerase and recombination. PloS one. 2011 Academic Article GET IT
Times cited: 14
Telomerase regulatory subunit Est3 in two Candida species physically interacts with the TEN domain of TERT and telomeric DNA. Proceedings of the National Academy of Sciences of the United States of America. 2011 Academic Article GET IT
Times cited: 18
A web of interactions at the ends. Molecular cell. 2011 Comment GET IT
Times cited: 2
Analysis of yeast telomerase by primer extension assays. Methods in molecular biology (Clifton, N.J.). 2011 Academic Article GET IT
Times cited: 2
Structural bases of dimerization of yeast telomere protein Cdc13 and its interaction with the catalytic subunit of DNA polymerase α. Cell research. 2010 Academic Article GET IT
Times cited: 60
Stn1-Ten1 is an Rpa2-Rpa3-like complex at telomeres. Genes & development. 2009 Academic Article GET IT
Times cited: 114
Rap1 in Candida albicans: an unusual structural organization and a critical function in suppressing telomere recombination. Molecular and cellular biology. 2009 Academic Article GET IT
Times cited: 31
Plasticity of telomere maintenance mechanisms in yeast. Trends in biochemical sciences. 2009 Review GET IT
Times cited: 52
Closing the feedback loop: how cells "count" telomere-bound proteins. Molecular cell. 2009 Comment GET IT
Times cited: 4
A proposed OB-fold with a protein-interaction surface in Candida albicans telomerase protein Est3. Nature structural & molecular biology. 2008 Academic Article GET IT
Times cited: 49
Modeling and structure function analysis of the putative anchor site of yeast telomerase. Nucleic acids research. 2007 Academic Article GET IT
Times cited: 16
Telomerase core components protect Candida telomeres from aberrant overhang accumulation. Proceedings of the National Academy of Sciences of the United States of America. 2007 Academic Article GET IT
Times cited: 29
Regulation of telomere structure and functions by subunits of the INO80 chromatin remodeling complex. Molecular and cellular biology. 2007 Academic Article GET IT
Times cited: 43
Mutual dependence of Candida albicans Est1p and Est3p in telomerase assembly and activation. Eukaryotic cell. 2007 Academic Article GET IT
Times cited: 30
Modulation of telomere terminal structure by telomerase components in Candida albicans. Nucleic acids research. 2006 Academic Article GET IT
Times cited: 11
The structure and function of telomerase reverse transcriptase. Annual review of biochemistry. 2006 Review GET IT
Times cited: 380
Teaching resources. Chromatin remodeling. Science's STKE : signal transduction knowledge environment. 2005 Academic Article GET IT
Times cited: 2
Telomerase can act as a template- and RNA-independent terminal transferase. Proceedings of the National Academy of Sciences of the United States of America. 2005 Academic Article GET IT
Times cited: 41
A physical and functional constituent of telomerase anchor site. The Journal of biological chemistry. 2005 Academic Article GET IT
Times cited: 59
Reverse transcriptase at bacterial telomeres. Proceedings of the National Academy of Sciences of the United States of America. 2004 Comment GET IT
Adding to the ends: what makes telomerase processive and how important is it?. BioEssays : news and reviews in molecular, cellular and developmental biology. 2004 Review GET IT
Times cited: 64
Homologous recombination in Candida albicans: role of CaRad52p in DNA repair, integration of linear DNA fragments and telomere length. Molecular microbiology. 2004 Academic Article GET IT
Times cited: 50
Yeast telomerase is capable of limited repeat addition processivity. Nucleic acids research. 2004 Academic Article GET IT
Times cited: 22
A conserved telomerase motif within the catalytic domain of telomerase reverse transcriptase is specifically required for repeat addition processivity. Molecular and cellular biology. 2003 Academic Article GET IT
Times cited: 61
Ever shorter telomere 1 (EST1)-dependent reverse transcription by Candida telomerase in vitro: evidence in support of an activating function. Proceedings of the National Academy of Sciences of the United States of America. 2003 Academic Article GET IT
Times cited: 26
mRNAs encoding telomerase components and regulators are controlled by UPF genes in Saccharomyces cerevisiae. Eukaryotic cell. 2003 Academic Article GET IT
Times cited: 60
Analysis of telomerase in Candida albicans: potential role in telomere end protection. Eukaryotic cell. 2002 Academic Article GET IT
Times cited: 42
Conserved N-terminal motifs of telomerase reverse transcriptase required for ribonucleoprotein assembly in vivo. The Journal of biological chemistry. 2002 Academic Article GET IT
Times cited: 70
Functional analysis of the C-terminal extension of telomerase reverse transcriptase. A putative "thumb" domain. The Journal of biological chemistry. 2002 Academic Article GET IT
Times cited: 56
Functional analysis of conserved residues in the putative "finger" domain of telomerase reverse transcriptase. The Journal of biological chemistry. 2001 Academic Article GET IT
Times cited: 38
Analysis of telomerase processivity: mechanistic similarity to HIV-1 reverse transcriptase and role in telomere maintenance. Molecular cell. 2001 Academic Article GET IT
Times cited: 105
Characterization of the interaction between the nuclease and reverse transcriptase activity of the yeast telomerase complex. Molecular and cellular biology. 2000 Academic Article GET IT
Times cited: 24
Identification of functionally important domains in the N-terminal region of telomerase reverse transcriptase. Molecular and cellular biology. 2000 Academic Article GET IT
Times cited: 121
Sequence-specific and conformation-dependent binding of yeast telomerase RNA to single-stranded telomeric DNA. Nucleic acids research. 1999 Academic Article GET IT
Times cited: 9
Negative regulation of yeast telomerase activity through an interaction with an upstream region of the DNA primer. Nucleic acids research. 1998 Academic Article GET IT
Times cited: 39
Species-specific and sequence-specific recognition of the dG-rich strand of telomeres by yeast telomerase. Nucleic acids research. 1998 Academic Article GET IT
Times cited: 17
Identification and characterization of a telomerase activity from Schizosaccharomyces pombe. Nucleic acids research. 1997 Academic Article GET IT
Times cited: 28
Cdc13p: a single-strand telomeric DNA-binding protein with a dual role in yeast telomere maintenance. Science (New York, N.Y.). 1996 Academic Article GET IT
Times cited: 516
A 26 kDa yeast DNA topoisomerase I fragment: crystallographic structure and mechanistic implications. Structure (London, England : 1993). 1995 Academic Article GET IT
Times cited: 30
ATP-dependent processivity of a telomerase activity from Saccharomyces cerevisiae. The Journal of biological chemistry. 1995 Academic Article GET IT
Times cited: 21
A possible role for the yeast TATA-element-binding protein in DNA replication. Proceedings of the National Academy of Sciences of the United States of America. 1993 Academic Article GET IT
Times cited: 18
RNA polymerase II transcription in vitro. Methods in enzymology. 1991 Academic Article GET IT
Times cited: 25
Interchangeable RNA polymerase I and II enhancers. Proceedings of the National Academy of Sciences of the United States of America. 1990 Academic Article GET IT
Times cited: 10
Accurately initiated, enhancer-dependent transcription by RNA polymerase I in yeast extracts. The Journal of biological chemistry. 1990 Academic Article GET IT
Times cited: 12
Resolution of factors required for the initiation of transcription by yeast RNA polymerase II. The Journal of biological chemistry. 1990 Academic Article GET IT
Times cited: 36
A yeast protein that influences the chromatin structure of UASG and functions as a powerful auxiliary gene activator. Genes & development. 1990 Academic Article GET IT
Times cited: 163
Initiation by yeast RNA polymerase II at the adenoviral major late promoter in vitro. Science (New York, N.Y.). 1989 Academic Article GET IT
Times cited: 58
Activation of yeast RNA polymerase II transcription by a thymidine-rich upstream element in vitro. Proceedings of the National Academy of Sciences of the United States of America. 1989 Academic Article GET IT
Times cited: 75
Connections between transcriptional activators, silencers, and telomeres as revealed by functional analysis of a yeast DNA-binding protein. Molecular and cellular biology. 1988 Academic Article GET IT
Times cited: 202
Statistical positioning of nucleosomes by specific protein-binding to an upstream activating sequence in yeast. Journal of molecular biology. 1988 Academic Article GET IT
Times cited: 185
Accurate initiation at RNA polymerase II promoters in extracts from Saccharomyces cerevisiae. Proceedings of the National Academy of Sciences of the United States of America. 1987 Academic Article GET IT
Times cited: 94
Interaction of GAL4 and GAL80 gene regulatory proteins in vitro. Molecular and cellular biology. 1987 Academic Article GET IT
Times cited: 105
Biosynthesis of myelin-associated proteins in simian virus 40 (SV40)-transformed rat Schwann cell lines. Brain research. 1987 Academic Article GET IT
Times cited: 16
Effect of dimethyl sulfoxide on transformed rat Schwann cells. Biochimica et biophysica acta. 1987 Academic Article GET IT
Times cited: 3
A GAL family of upstream activating sequences in yeast: roles in both induction and repression of transcription. The EMBO journal. 1986 Academic Article GET IT
Times cited: 89

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Research

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Funding awarded

Multifaceted regulation of DNA repair machinery and suppression of aberrant transcription by telomere proteins awarded by National Science Foundation Principal Investigator 2023 - 2027
Telomere terminal extension and replication: mechanisms and links to DNA repair awarded by National Institute of General Medical Sciences Principal Investigator 2023 - 2024
Telomere terminal extension and replication: mechanisms and links to DNA repair - Supplement awarded by National Institute of General Medical Sciences Principal Investigator 2023 - 2024
Telomere terminal extension and replication: mechanisms and links to DNA repair awarded by National Institute of General Medical Sciences Principal Investigator 2020 - 2024

Mutational and Aging Risk Factors for Myelodysplastic Syndrome awarded by United States Department of Defense Co-Investigator 2023 - 2026

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Background

education and training

M.D., Ph.D., Stanford University School of Medicine 1991
B.S., The Johns Hopkins University 1984

Contact

full name

Neal F Lue

primary email

nflue@med.cornell.edu

VIVO Weill Cornell Medical College

Neal F Lue Professor of Microbiology and Immunology

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email