Scheuring, Simon

Publications

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selected publications

Forces and energetics of the canonical tetrameric cation channel gating. Proceedings of the National Academy of Sciences of the United States of America. 2023 Academic Article GET IT
Times cited: 164
Discrimination between cyclic nucleotides in a cyclic nucleotide-gated ion channel. Nature structural & molecular biology. 2023 Academic Article GET IT
Structure and dynamics of ESCRT-III membrane remodeling proteins by high-speed atomic force microscopy. The Journal of biological chemistry. 2023 Review GET IT
Membrane-mediated protein interactions drive membrane protein organization. Nature communications. 2022 Academic Article GET IT
Times cited: 4
Perforin-2 clockwise hand-over-hand pre-pore to pore transition mechanism. Nature communications. 2022 Academic Article GET IT
Times cited: 5
TMEM16 scramblases thin the membrane to enable lipid scrambling. Nature communications. 2022 Academic Article GET IT
Times cited: 7
Shape-Morphing of an Artificial Protein Cage with Unusual Geometry Induced by a Single Amino Acid Change. ACS nanoscience Au. 2022 Academic Article GET IT
Times cited: 14
Snf7 spirals sense and alter membrane curvature. Nature communications. 2022 Academic Article GET IT
Times cited: 5
Chemically induced protein cage assembly with programmable opening and cargo release. Science advances. 2022 Academic Article GET IT
Times cited: 11
Single molecule kinetics of bacteriorhodopsin by HS-AFM. Nature communications. 2021 Academic Article GET IT
Times cited: 5
Nanodissected elastically loaded clathrin lattices relax to increased curvature. Science advances. 2021 Academic Article GET IT
Times cited: 6
Correlation of membrane protein conformational and functional dynamics. Nature communications. 2021 Academic Article GET IT
Times cited: 8
Localization atomic force microscopy. Nature. 2021 Academic Article GET IT
Times cited: 61
Quantitative description of a contractile macromolecular machine. Science advances. 2021 Academic Article GET IT
Times cited: 2
Structural dynamics of channels and transporters by high-speed atomic force microscopy. Methods in enzymology. 2021 Academic Article GET IT
Times cited: 2
High-speed atomic force microscopy to study pore-forming proteins. Methods in enzymology. 2021 Academic Article GET IT
Times cited: 9
High-speed atomic force microscopy tracks the dynamic parts of the ribosome. Proceedings of the National Academy of Sciences of the United States of America. 2021 Comment GET IT
Times cited: 2
Nanoreporter of an Enzymatic Suicide Inactivation Pathway. Nano letters. 2020 Academic Article GET IT
Times cited: 15
The hierarchical assembly of septins revealed by high-speed AFM. Nature communications. 2020 Academic Article GET IT
Times cited: 24
Millisecond dynamics of an unlabeled amino acid transporter. Nature communications. 2020 Academic Article GET IT
Times cited: 15
Structure and mechanism of bactericidal mammalian perforin-2, an ancient agent of innate immunity. Science advances. 2020 Academic Article GET IT
Times cited: 41
Annexin-V stabilizes membrane defects by inducing lipid phase transition. Nature communications. 2020 Academic Article GET IT
Times cited: 44
Real time dynamics of Gating-Related conformational changes in CorA. eLife. 2019 Academic Article GET IT
Times cited: 14
Force-induced conformational changes in PIEZO1. Nature. 2019 Academic Article GET IT
Times cited: 151
Heterogeneous and rate-dependent streptavidin-biotin unbinding revealed by high-speed force spectroscopy and atomistic simulations. Proceedings of the National Academy of Sciences of the United States of America. 2019 Academic Article GET IT
Times cited: 79
Advances in high-speed atomic force microscopy (HS-AFM) reveal dynamics of transmembrane channels and transporters. Current opinion in structural biology. 2019 Review GET IT
Times cited: 48
Fifteen years of Servitude et Grandeur to the application of a biophysical technique in medicine: The tale of AFMBioMed. Journal of molecular recognition : JMR. 2018 Editorial Article GET IT
Times cited: 2
High-speed AFM height spectroscopy reveals µs-dynamics of unlabeled biomolecules. Nature communications. 2018 Academic Article GET IT
Times cited: 45
An iris diaphragm mechanism to gate a cyclic nucleotide-gated ion channel. Nature communications. 2018 Academic Article GET IT
Times cited: 37
Structural titration of receptor ion channel GLIC gating by HS-AFM. Proceedings of the National Academy of Sciences of the United States of America. 2018 Academic Article GET IT
Times cited: 28
A novel phase-shift-based amplitude detector for a high-speed atomic force microscope. The Review of scientific instruments. 2018 Academic Article GET IT
Times cited: 18
α-Helix Unwinding as Force Buffer in Spectrins. ACS nano. 2018 Academic Article GET IT
Times cited: 29
High-Speed Force Spectroscopy for Single Protein Unfolding. Methods in molecular biology (Clifton, N.J.). 2018 Academic Article GET IT
Times cited: 10
High-Speed Atomic Force Microscopy Reveals the Inner Workings of the MinDE Protein Oscillator. Nano letters. 2017 Academic Article GET IT
Times cited: 19
Lysenin Toxin Membrane Insertion Is pH-Dependent but Independent of Neighboring Lysenins. Biophysical journal. 2017 Academic Article GET IT
Times cited: 14
Applications of high-speed atomic force microscopy to real-time visualization of dynamic biomolecular processes. Biochimica et biophysica acta. General subjects. 2017 Review GET IT
Times cited: 36
Standardized Nanomechanical Atomic Force Microscopy Procedure (SNAP) for Measuring Soft and Biological Samples. Scientific reports. 2017 Academic Article GET IT
Times cited: 152
Dynamic subunit turnover in ESCRT-III assemblies is regulated by Vps4 to mediate membrane remodelling during cytokinesis. Nature cell biology. 2017 Academic Article GET IT
Times cited: 147
Dynamic remodeling of the dynamin helix during membrane constriction. Proceedings of the National Academy of Sciences of the United States of America. 2017 Academic Article GET IT
Times cited: 32
High-frequency microrheology reveals cytoskeleton dynamics in living cells. Nature physics. 2017 Academic Article GET IT
Times cited: 141
Real-time Visualization of Phospholipid Degradation by Outer Membrane Phospholipase A using High-Speed Atomic Force Microscopy. Journal of molecular biology. 2017 Academic Article GET IT
Times cited: 20
Engineering a pH responsive pore forming protein. Scientific reports. 2017 Academic Article GET IT
Times cited: 24
Direct visualization of glutamate transporter elevator mechanism by high-speed AFM. Proceedings of the National Academy of Sciences of the United States of America. 2017 Academic Article GET IT
Times cited: 83
Real-time visualization of conformational changes within single MloK1 cyclic nucleotide-modulated channels. Nature communications. 2016 Academic Article GET IT
Times cited: 23
Temperature-Controlled High-Speed AFM: Real-Time Observation of Ripple Phase Transitions. Small (Weinheim an der Bergstrasse, Germany). 2016 Academic Article GET IT
Times cited: 15
Effect of Statins on the Nanomechanical Properties of Supported Lipid Bilayers. Biophysical journal. 2016 Academic Article GET IT
Times cited: 29
Identification of a Membrane-bound Prepore Species Clarifies the Lytic Mechanism of Actinoporins. The Journal of biological chemistry. 2016 Academic Article GET IT
Times cited: 25
High-speed atomic force microscopy shows that annexin V stabilizes membranes on the second timescale. Nature nanotechnology. 2016 Academic Article GET IT
Times cited: 79
Automated force controller for amplitude modulation atomic force microscopy. The Review of scientific instruments. 2016 Academic Article GET IT
Times cited: 14
Listeriolysin O Membrane Damaging Activity Involves Arc Formation and Lineaction -- Implication for Listeria monocytogenes Escape from Phagocytic Vacuole. PLoS pathogens. 2016 Academic Article GET IT
Times cited: 66
Temperature-Switchable Control of Ligand Display on Adlayers of Mixed Poly(lysine)-g-(PEO) and Poly(lysine)-g-(ligand-modified poly-N-isopropylacrylamide). Biomacromolecules. 2016 Academic Article GET IT
Times cited: 20
Glasslike Membrane Protein Diffusion in a Crowded Membrane. ACS nano. 2016 Academic Article GET IT
Times cited: 38
Relaxation of Loaded ESCRT-III Spiral Springs Drives Membrane Deformation. Cell. 2015 Academic Article GET IT
Times cited: 220
Atomic Force Microscopy Mechanical Mapping of Micropatterned Cells Shows Adhesion Geometry-Dependent Mechanical Response on Local and Global Scales. ACS nano. 2015 Academic Article GET IT
Times cited: 51
Corrigendum to "High-speed atomic force microscopy: Imaging and force spectroscopy" [FEBS Lett. 588 (19) (2014) 3631-3638]. FEBS letters. 2015 Article GET IT
Structural, mechanical, and dynamical variability of the actin cortex in living cells. Biophysical journal. 2015 Academic Article GET IT
Times cited: 86
Cannabinoid-induced actomyosin contractility shapes neuronal morphology and growth. eLife. 2014 Academic Article GET IT
Times cited: 54
High-speed atomic force microscopy: imaging and force spectroscopy. FEBS letters. 2014 Review GET IT
Times cited: 49
Light harvesting by lamellar chromatophores in Rhodospirillum photometricum. Biophysical journal. 2014 Academic Article GET IT
Times cited: 46
The architecture of Rhodobacter sphaeroides chromatophores. Biochimica et biophysica acta. 2014 Academic Article GET IT
Times cited: 31
Filming biomolecular processes by high-speed atomic force microscopy. Chemical reviews. 2014 Review GET IT
Times cited: 266
Ligand-induced structural changes in the cyclic nucleotide-modulated potassium channel MloK1. Nature communications. 2014 Academic Article GET IT
Times cited: 55
Mechanics of proteins with a focus on atomic force microscopy. Journal of nanobiotechnology. 2013 Academic Article GET IT
Times cited: 17
High-speed force spectroscopy unfolds titin at the velocity of molecular dynamics simulations. Science (New York, N.Y.). 2013 Academic Article GET IT
Times cited: 190
High-speed atomic force microscopy tracks toxin action. Biophysical journal. 2013 Comment GET IT
Times cited: 1
Cellular capsules as a tool for multicellular spheroid production and for investigating the mechanics of tumor progression in vitro. Proceedings of the National Academy of Sciences of the United States of America. 2013 Academic Article GET IT
Times cited: 298
Investigation of photosynthetic membrane structure using atomic force microscopy. Trends in plant science. 2013 Review GET IT
Times cited: 49
Structural and mechanical heterogeneity of the erythrocyte membrane reveals hallmarks of membrane stability. ACS nano. 2013 Academic Article GET IT
Times cited: 59
A hybrid high-speed atomic force-optical microscope for visualizing single membrane proteins on eukaryotic cells. Nature communications. 2013 Academic Article GET IT
Times cited: 60
High-speed atomic force microscopy: cooperative adhesion and dynamic equilibrium of junctional microdomain membrane proteins. Journal of molecular biology. 2012 Academic Article GET IT
Times cited: 26
Characterization of the motion of membrane proteins using high-speed atomic force microscopy. Nature nanotechnology. 2012 Academic Article GET IT
Times cited: 165
AFMBioMed Conference: Paris, France, August 2011. Journal of molecular recognition : JMR. 2012 Editorial Article GET IT
Times cited: 5
Software for drift compensation, particle tracking and particle analysis of high-speed atomic force microscopy image series. Journal of molecular recognition : JMR. 2012 Academic Article GET IT
Times cited: 34
Nanomechanical characterization of the stiffness of eye lens cells: a pilot study. Investigative ophthalmology & visual science. 2012 Academic Article GET IT
Times cited: 15
Direct measurement of the mechanical properties of lipid phases in supported bilayers. Biophysical journal. 2012 Letter GET IT
Times cited: 155
Mechanical mapping of single membrane proteins at submolecular resolution. Nano letters. 2011 Academic Article GET IT
Times cited: 114
Two-dimensional kinetics of inter-connexin interactions from single-molecule force spectroscopy. Journal of molecular biology. 2011 Academic Article GET IT
Times cited: 9
High-speed atomic force microscopy: Structure and dynamics of single proteins. Current opinion in chemical biology. 2011 Review GET IT
Times cited: 27
Forces guiding assembly of light-harvesting complex 2 in native membranes. Proceedings of the National Academy of Sciences of the United States of America. 2011 Academic Article GET IT
Times cited: 44
Förster energy transfer theory as reflected in the structures of photosynthetic light-harvesting systems. Chemphyschem : a European journal of chemical physics and physical chemistry. 2011 Review GET IT
Times cited: 115
Biological AFM: where we come from--where we are--where we may go. Journal of molecular recognition : JMR. 2011 Review GET IT
Times cited: 89
Rhodopsin is spatially heterogeneously distributed in rod outer segment disk membranes. Journal of molecular recognition : JMR. 2011 Academic Article GET IT
Times cited: 37
Experimental evidence for membrane-mediated protein-protein interaction. Biophysical journal. 2010 Letter GET IT
Times cited: 68
Native architecture of the photosynthetic membrane from Rhodobacter veldkampii. Journal of structural biology. 2010 Academic Article GET IT
Times cited: 32
Antenna mixing in photosynthetic membranes from Phaeospirillum molischianum. Proceedings of the National Academy of Sciences of the United States of America. 2010 Academic Article GET IT
Times cited: 31
Atomic force microscopy: probing the spatial organization, interactions and elasticity of microbial cell envelopes at molecular resolution. Molecular microbiology. 2010 Review GET IT
Times cited: 75
Automated setpoint adjustment for biological contact mode atomic force microscopy imaging. Nanotechnology. 2010 Academic Article GET IT
Times cited: 15
Energy transfer in light-adapted photosynthetic membranes: from active to saturated photosynthesis. Biophysical journal. 2009 Academic Article GET IT
Times cited: 54
Introduction to atomic force microscopy (AFM) in biology. Current protocols in protein science. 2009 Academic Article GET IT
Times cited: 25
High-resolution architecture of the outer membrane of the Gram-negative bacteria Roseobacter denitrificans. Molecular microbiology. 2009 Academic Article GET IT
Times cited: 59
Contact-mode high-resolution high-speed atomic force microscopy movies of the purple membrane. Biophysical journal. 2009 Academic Article GET IT
Times cited: 55
Quinone pathways in entire photosynthetic chromatophores of Rhodospirillum photometricum. Journal of molecular biology. 2009 Academic Article GET IT
Times cited: 28
Structural information, resolution, and noise in high-resolution atomic force microscopy topographs. Biophysical journal. 2009 Academic Article GET IT
Times cited: 47
Atomic force microscopy of the bacterial photosynthetic apparatus: plain pictures of an elaborate machinery. Photosynthesis research. 2009 Academic Article GET IT
Times cited: 61
Malformation of junctional microdomains in cataract lens membranes from a type II diabetes patient. Pflugers Archiv : European journal of physiology. 2008 Academic Article GET IT
Times cited: 20
Mini review on the structure and supramolecular assembly of VDAC. Journal of bioenergetics and biomembranes. 2008 Review GET IT
Times cited: 25
Direct visualization of KirBac3.1 potassium channel gating by atomic force microscopy. Journal of molecular biology. 2007 Academic Article GET IT
Times cited: 23
Human cataract lens membrane at subnanometer resolution. 2007 GET IT
Times cited: 49
Structural models of the supramolecular organization of AQP0 and connexons in junctional microdomains. Journal of structural biology. 2007 Academic Article GET IT
Times cited: 42
Rows of ATP synthase dimers in native mitochondrial inner membranes. Biophysical journal. 2007 Academic Article GET IT
Times cited: 80
Supramolecular assembly of VDAC in native mitochondrial outer membranes. Journal of molecular biology. 2007 Academic Article GET IT
Times cited: 122
From high-resolution AFM topographs to atomic models of supramolecular assemblies. Journal of structural biology. 2007 Academic Article GET IT
Times cited: 61
Past, present and future of atomic force microscopy in life sciences and medicine. Journal of molecular recognition : JMR. 2007 Review GET IT
Times cited: 158
The supramolecular architecture of junctional microdomains in native lens membranes. EMBO reports. 2006 Academic Article GET IT
Times cited: 89
Two-chamber AFM: probing membrane proteins separating two aqueous compartments. Nature methods. 2006 Academic Article GET IT
Times cited: 87
Dynamics and diffusion in photosynthetic membranes from rhodospirillum photometricum. Biophysical journal. 2006 Academic Article GET IT
Times cited: 30
AFM studies of the supramolecular assembly of bacterial photosynthetic core-complexes. Current opinion in chemical biology. 2006 Review GET IT
Times cited: 64
Single-molecule studies of membrane proteins. Current opinion in structural biology. 2006 Review GET IT
Times cited: 86
The photosynthetic apparatus of Rhodopseudomonas palustris: structures and organization. Journal of molecular biology. 2006 Academic Article GET IT
Times cited: 110
Architecture of the native photosynthetic apparatus of Phaeospirillum molischianum. Journal of structural biology. 2005 Academic Article GET IT
Times cited: 70
Chromatic adaptation of photosynthetic membranes. Science (New York, N.Y.). 2005 Academic Article GET IT
Times cited: 228
The 4.5 A structure of human AQP2. Journal of molecular biology. 2005 Academic Article GET IT
Times cited: 70
Watching the components of photosynthetic bacterial membranes and their in situ organisation by atomic force microscopy. Biochimica et biophysica acta. 2005 Review GET IT
Times cited: 93
Membrane insertion of Rhodopseudomonas acidophila light harvesting complex 2 investigated by high resolution AFM. Journal of structural biology. 2005 Academic Article GET IT
Times cited: 30
Structure of the dimeric PufX-containing core complex of Rhodobacter blasticus by in situ atomic force microscopy. The Journal of biological chemistry. 2004 Academic Article GET IT
Times cited: 100
Variable LH2 stoichiometry and core clustering in native membranes of Rhodospirillum photometricum. The EMBO journal. 2004 Academic Article GET IT
Times cited: 125
Watching the photosynthetic apparatus in native membranes. Proceedings of the National Academy of Sciences of the United States of America. 2004 Academic Article GET IT
Times cited: 151
Carbohydrate-carbohydrate interaction provides adhesion force and specificity for cellular recognition. The Journal of cell biology. 2004 Academic Article GET IT
Times cited: 112
Structural role of PufX in the dimerization of the photosynthetic core complex of Rhodobacter sphaeroides. The Journal of biological chemistry. 2003 Academic Article GET IT
Times cited: 110
Nanodissection and high-resolution imaging of the Rhodopseudomonas viridis photosynthetic core complex in native membranes by AFM. Atomic force microscopy. Proceedings of the National Academy of Sciences of the United States of America. 2003 Academic Article GET IT
Times cited: 215
AFM characterization of tilt and intrinsic flexibility of Rhodobacter sphaeroides light harvesting complex 2 (LH2). Journal of molecular biology. 2003 Academic Article GET IT
Times cited: 76
Introduction to atomic force microscopy (AFM) in biology. Current protocols in protein science. 2002 Academic Article GET IT
Times cited: 4
Charting and unzipping the surface layer of Corynebacterium glutamicum with the atomic force microscope. Molecular microbiology. 2002 Academic Article GET IT
Times cited: 69
Sampling the conformational space of membrane protein surfaces with the AFM. European biophysics journal : EBJ. 2002 Academic Article GET IT
Times cited: 63
Imaging and manipulation of biological structures with the AFM. Micron (Oxford, England : 1993). 2002 Review GET IT
Times cited: 355
Two-dimensional crystals: a powerful approach to assess structure, function and dynamics of membrane proteins. FEBS letters. 2001 Review GET IT
Times cited: 79
High-resolution AFM topographs of Rubrivivax gelatinosus light-harvesting complex LH2. The EMBO journal. 2001 Academic Article GET IT
Times cited: 110
The aquaporin sidedness revisited. Journal of molecular biology. 2000 Academic Article GET IT
Times cited: 19
High resolution AFM topographs of the Escherichia coli water channel aquaporin Z. The EMBO journal. 1999 Academic Article GET IT
Times cited: 165
Electrostatically balanced subnanometer imaging of biological specimens by atomic force microscope. Biophysical journal. 1999 Academic Article GET IT
Times cited: 289
Imaging streptavidin 2D crystals on biotinylated lipid monolayers at high resolution with the atomic force microscope. Journal of microscopy. 1999 Academic Article GET IT
Times cited: 97

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Research

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Co-investigator Network

Funding awarded

Next Generation High-Speed Atomic Force Microscope (NG-HS-AFM) awarded by W. M. Keck Foundation Principal Investigator 2022 - 2025
Functional dynamics of glutamate transporters probed by high-speed atomic force microscopy with micro- to millisecond time resolution awarded by National Institute of Neurological Disorders & Stroke Principal Investigator 2019 - 2024
Enabling physical stimuli in the study of structural dynamics: The sensory ion channels awarded by National Center for Complementary and Integrative Health/NIH/DHHS Principal Investigator 2019 - 2024

Structural dynamics in cyclic nucleotide-modulated channels awarded by National Institute of General Medical Sciences Co-Investigator 2021 - 2025

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Background

education and training

Ph.D., University of Basel (Switzerland) 2001
M.S., University of Basel (Switzerland) 1996

Contact

full name

Simon Scheuring

primary email

sis2019@med.cornell.edu

VIVO Weill Cornell Medical College

Simon Scheuring Professor of Physiology and Biophysics in Anesthesiology

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

Phone

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email